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Intravenous nicardipine for treatment of severe hypertension in children.
J Pediatr. 2001 Jul; 139(1):38-43.JPed

Abstract

OBJECTIVE

To examine the effect of intravenous nicardipine in the treatment of children with severe hypertension.

METHODS

The medical records of 29 children (mean age 94 months) treated with intravenous nicardipine were retrospectively reviewed. The mean duration of severe hypertension before nicardipine use was 12.5 hours. Most (74%) patients were receiving other antihypertensive agents before nicardipine.

RESULTS

The initial nicardipine dose was 0.8 +/- 0.3 microg/kg/min (mean +/- SD). The mean effective dose was 1.8 +/- 1.0 microg/kg/min (range, 0.3 to 4.0). Blood pressure control was achieved within 2.7 +/- 2.1 hours after nicardipine was started. Nicardipine treatment produced a 16% reduction in systolic blood pressure, a 23% reduction in diastolic blood pressure, and a 7% increase in heart rate. Nicardipine was effective as a single agent on 26 (84%) of 31 occasions. Adverse effects included tachycardia, flushing, palpitations, and hypotension.

CONCLUSIONS

When administered in the intensive care unit setting with close patient monitoring, intravenous nicardipine effectively lowered blood pressure in children with severe hypertension. Larger prospective studies should be conducted to confirm these findings.

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Authors+Show Affiliations

Flynn JT
Division of Pediatric Nephrology, Department of Pediatrics and Communicable Diseases, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, USA.
Mottes TA
No affiliation info available
Brophy PD
No affiliation info available
Kershaw DB
No affiliation info available
Smoyer WE
No affiliation info available
Bunchman TE
No affiliation info available

MeSH

Antihypertensive AgentsBlood PressureChildChild, PreschoolDose-Response Relationship, DrugFemaleHumansHypertensionInfantInfusions, IntravenousIntensive Care Units, PediatricMaleNicardipineRetrospective StudiesTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11445792

Citation

Flynn, J T., et al. "Intravenous Nicardipine for Treatment of Severe Hypertension in Children." The Journal of Pediatrics, vol. 139, no. 1, 2001, pp. 38-43.
Flynn JT, Mottes TA, Brophy PD, et al. Intravenous nicardipine for treatment of severe hypertension in children. J Pediatr. 2001;139(1):38-43.
Flynn, J. T., Mottes, T. A., Brophy, P. D., Kershaw, D. B., Smoyer, W. E., & Bunchman, T. E. (2001). Intravenous nicardipine for treatment of severe hypertension in children. The Journal of Pediatrics, 139(1), 38-43.
Flynn JT, et al. Intravenous Nicardipine for Treatment of Severe Hypertension in Children. J Pediatr. 2001;139(1):38-43. PubMed PMID: 11445792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intravenous nicardipine for treatment of severe hypertension in children. AU - Flynn,J T, AU - Mottes,T A, AU - Brophy,P D, AU - Kershaw,D B, AU - Smoyer,W E, AU - Bunchman,T E, PY - 2001/7/11/pubmed PY - 2001/8/17/medline PY - 2001/7/11/entrez SP - 38 EP - 43 JF - The Journal of pediatrics JO - J Pediatr VL - 139 IS - 1 N2 - OBJECTIVE: To examine the effect of intravenous nicardipine in the treatment of children with severe hypertension. METHODS: The medical records of 29 children (mean age 94 months) treated with intravenous nicardipine were retrospectively reviewed. The mean duration of severe hypertension before nicardipine use was 12.5 hours. Most (74%) patients were receiving other antihypertensive agents before nicardipine. RESULTS: The initial nicardipine dose was 0.8 +/- 0.3 microg/kg/min (mean +/- SD). The mean effective dose was 1.8 +/- 1.0 microg/kg/min (range, 0.3 to 4.0). Blood pressure control was achieved within 2.7 +/- 2.1 hours after nicardipine was started. Nicardipine treatment produced a 16% reduction in systolic blood pressure, a 23% reduction in diastolic blood pressure, and a 7% increase in heart rate. Nicardipine was effective as a single agent on 26 (84%) of 31 occasions. Adverse effects included tachycardia, flushing, palpitations, and hypotension. CONCLUSIONS: When administered in the intensive care unit setting with close patient monitoring, intravenous nicardipine effectively lowered blood pressure in children with severe hypertension. Larger prospective studies should be conducted to confirm these findings. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/11445792/Intravenous_nicardipine_for_treatment_of_severe_hypertension_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(01)29738-8 DB - PRIME DP - Unbound Medicine ER -