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The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism.
Menopause 2001 Jul-Aug; 8(4):259-65M

Abstract

OBJECTIVE

This study was undertaken to evaluate the effects of varying doses of phytoestrogens on lipid and bone metabolism in postmenopausal women.

DESIGN

A novel red clover isoflavone preparation (Rimostil) containing genistein, daidzein, formononetin, and biochanin was administered to 46 postmenopausal women in a double-blind protocol after a single-blind placebo phase and followed by a single-blind washout phase. Patients were randomized to receive either 28.5 mg, 57 mg, or 85.5 mg of phytoestrogens daily for a 6-month period.

RESULTS

At 6 months, the serum high-density lipoprotein cholesterol had risen significantly by 15.7-28.6% with different doses (p = 0.007, p = 0.002, p = 0.027), although the magnitude of the response was independent of the dose used. The serum apolipoprotein B fell significantly by 11.5-17.0% with different doses (p = 0.005, p = 0.043, p = 0.007) and the magnitude of the response was independent of the dose used. The bone mineral density of the proximal radius and ulna rose significantly by 4.1% over 6 months with 57 mg/day (p = 0.002) and by 3.0% with 85.5 mg/day (p = 0.023) of isoflavones. The response with 28.5 mg/day of isoflavones was not significant. There was no significant increase in endometrial thickness with any of the doses of isoflavone used.

CONCLUSION

These results show that the administration of an isoflavone combination extracted from red clover was associated with a significant increase in high-density lipoprotein cholesterol, a significant fall in apolipoprotein B, and a significant increase in the predominantly cortical bone of the proximal radius and ulna after 6 months of treatment. Interpretation of the results is undertaken cautiously because of the absence of a simultaneously studied control group.

Authors+Show Affiliations

Department of Endocrinology, Royal North Shore Hospital, St. Leonards NSW 2065, Australia. pclifton@med.usyd.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11449083

Citation

Clifton-Bligh, P B., et al. "The Effect of Isoflavones Extracted From Red Clover (Rimostil) On Lipid and Bone Metabolism." Menopause (New York, N.Y.), vol. 8, no. 4, 2001, pp. 259-65.
Clifton-Bligh PB, Baber RJ, Fulcher GR, et al. The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism. Menopause. 2001;8(4):259-65.
Clifton-Bligh, P. B., Baber, R. J., Fulcher, G. R., Nery, M. L., & Moreton, T. (2001). The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism. Menopause (New York, N.Y.), 8(4), pp. 259-65.
Clifton-Bligh PB, et al. The Effect of Isoflavones Extracted From Red Clover (Rimostil) On Lipid and Bone Metabolism. Menopause. 2001;8(4):259-65. PubMed PMID: 11449083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism. AU - Clifton-Bligh,P B, AU - Baber,R J, AU - Fulcher,G R, AU - Nery,M L, AU - Moreton,T, PY - 2001/7/13/pubmed PY - 2001/9/8/medline PY - 2001/7/13/entrez SP - 259 EP - 65 JF - Menopause (New York, N.Y.) JO - Menopause VL - 8 IS - 4 N2 - OBJECTIVE: This study was undertaken to evaluate the effects of varying doses of phytoestrogens on lipid and bone metabolism in postmenopausal women. DESIGN: A novel red clover isoflavone preparation (Rimostil) containing genistein, daidzein, formononetin, and biochanin was administered to 46 postmenopausal women in a double-blind protocol after a single-blind placebo phase and followed by a single-blind washout phase. Patients were randomized to receive either 28.5 mg, 57 mg, or 85.5 mg of phytoestrogens daily for a 6-month period. RESULTS: At 6 months, the serum high-density lipoprotein cholesterol had risen significantly by 15.7-28.6% with different doses (p = 0.007, p = 0.002, p = 0.027), although the magnitude of the response was independent of the dose used. The serum apolipoprotein B fell significantly by 11.5-17.0% with different doses (p = 0.005, p = 0.043, p = 0.007) and the magnitude of the response was independent of the dose used. The bone mineral density of the proximal radius and ulna rose significantly by 4.1% over 6 months with 57 mg/day (p = 0.002) and by 3.0% with 85.5 mg/day (p = 0.023) of isoflavones. The response with 28.5 mg/day of isoflavones was not significant. There was no significant increase in endometrial thickness with any of the doses of isoflavone used. CONCLUSION: These results show that the administration of an isoflavone combination extracted from red clover was associated with a significant increase in high-density lipoprotein cholesterol, a significant fall in apolipoprotein B, and a significant increase in the predominantly cortical bone of the proximal radius and ulna after 6 months of treatment. Interpretation of the results is undertaken cautiously because of the absence of a simultaneously studied control group. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/11449083/The_effect_of_isoflavones_extracted_from_red_clover__Rimostil__on_lipid_and_bone_metabolism_ L2 - http://dx.doi.org/10.1097/00042192-200107000-00007 DB - PRIME DP - Unbound Medicine ER -