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Bone turnover and density in obese premenopausal women during moderate weight loss and calcium supplementation.
J Bone Miner Res 2001; 16(7):1329-36JB

Abstract

Bone turnover is increased during weight loss in postmenopausal women and can be suppressed with calcium supplementation. In this study, we assessed the influence of energy restriction with and without calcium supplementation (1 g/day) in premenopausal women. Thirty-eight obese premenopausal women (body mass index [BMI] of 35.0 +/- 3.9 kg/m2) completed a 6-month study of either moderate weight loss or weight maintenance. During weight loss, women were randomly assigned to either a calcium supplementation (n = 14) or placebo group (n = 14) and lost 7.5 +/- 2.5% of their body weight. The control group of women (n = 10) maintained their body weight. Total body and lumbar bone mineral density (LBMD) and content were measured by dual-energy X-ray absorptiometry (DXA) at baseline and after weight loss. Throughout the study, blood and urine samples were collected to measure bone turnover markers and hormones. During moderate energy restriction, dietary calcium intake decreased (p < 0.05) and the bone resorption marker deoxypyridinoline (DPD) increased slightly (p < or = 0.05) without evidence of bone loss. Calcium supplementation during weight loss tended to increase lumbar BMD by 1.7% (p = 0.05) compared with the placebo or weight maintenance groups. In contrast to our previous findings in postmenopausal women, premenopausal obese women who consume a low calcium diet do not lose bone over a 6-month period, whether their weight is stable or decreasing moderately.

Authors+Show Affiliations

Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901-8525, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11450709

Citation

Shapses, S A., et al. "Bone Turnover and Density in Obese Premenopausal Women During Moderate Weight Loss and Calcium Supplementation." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 16, no. 7, 2001, pp. 1329-36.
Shapses SA, Von Thun NL, Heymsfield SB, et al. Bone turnover and density in obese premenopausal women during moderate weight loss and calcium supplementation. J Bone Miner Res. 2001;16(7):1329-36.
Shapses, S. A., Von Thun, N. L., Heymsfield, S. B., Ricci, T. A., Ospina, M., Pierson, R. N., & Stahl, T. (2001). Bone turnover and density in obese premenopausal women during moderate weight loss and calcium supplementation. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 16(7), pp. 1329-36.
Shapses SA, et al. Bone Turnover and Density in Obese Premenopausal Women During Moderate Weight Loss and Calcium Supplementation. J Bone Miner Res. 2001;16(7):1329-36. PubMed PMID: 11450709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone turnover and density in obese premenopausal women during moderate weight loss and calcium supplementation. AU - Shapses,S A, AU - Von Thun,N L, AU - Heymsfield,S B, AU - Ricci,T A, AU - Ospina,M, AU - Pierson,R N,Jr AU - Stahl,T, PY - 2001/7/14/pubmed PY - 2002/1/19/medline PY - 2001/7/14/entrez SP - 1329 EP - 36 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 16 IS - 7 N2 - Bone turnover is increased during weight loss in postmenopausal women and can be suppressed with calcium supplementation. In this study, we assessed the influence of energy restriction with and without calcium supplementation (1 g/day) in premenopausal women. Thirty-eight obese premenopausal women (body mass index [BMI] of 35.0 +/- 3.9 kg/m2) completed a 6-month study of either moderate weight loss or weight maintenance. During weight loss, women were randomly assigned to either a calcium supplementation (n = 14) or placebo group (n = 14) and lost 7.5 +/- 2.5% of their body weight. The control group of women (n = 10) maintained their body weight. Total body and lumbar bone mineral density (LBMD) and content were measured by dual-energy X-ray absorptiometry (DXA) at baseline and after weight loss. Throughout the study, blood and urine samples were collected to measure bone turnover markers and hormones. During moderate energy restriction, dietary calcium intake decreased (p < 0.05) and the bone resorption marker deoxypyridinoline (DPD) increased slightly (p < or = 0.05) without evidence of bone loss. Calcium supplementation during weight loss tended to increase lumbar BMD by 1.7% (p = 0.05) compared with the placebo or weight maintenance groups. In contrast to our previous findings in postmenopausal women, premenopausal obese women who consume a low calcium diet do not lose bone over a 6-month period, whether their weight is stable or decreasing moderately. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/11450709/Bone_turnover_and_density_in_obese_premenopausal_women_during_moderate_weight_loss_and_calcium_supplementation_ L2 - https://doi.org/10.1359/jbmr.2001.16.7.1329 DB - PRIME DP - Unbound Medicine ER -