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Soy intake and the maintenance of peak bone mass in Hong Kong Chinese women.

Abstract

Our previous study on bone health among premenopausal women showed that bone mass consolidation is attained by the early 30s, and small loss of spinal bone mineral density (SBMD) occurs soon after peak bone mass attainment. Recent interest has been shown in the potential beneficial effects of phytoestrogens on bone health. However, data are lacking, particularly in Asian women. This study aims to investigate the effect of soy isoflavones intake on the maintenance of peak bone mass in a cohort of 132 women aged 30-40 years who were followed up for 3 years. Baseline measurements of SBMD (L2-L4) were obtained using dual-energy X-ray densitometry, and dietary intake of soy foods and other key nutrients, including dietary calcium, were obtained through a quantitative food frequency method. Information on body measurements; physical activity (PA), weight-bearing activity in particular; age of menarche; and number of pregnancies were obtained at baseline. Repeated measurements of SBMD were obtained yearly for a further 3 years with an average follow-up time of 38 months. Analyses were performed on 116 subjects with at least three SBMD measurements (at baseline, 3-year follow-up, and at least one measurement during follow-up). The individual SBMD regression slope was computed for each of the subjects. Soy isoflavones consumption was categorized as quartiles of intake. We observed a significant difference in the SBMD individual regression slopes between women belonging to the fourth and first soy isoflavones intake quartiles. The positive effect of soy isoflavones on SBMD remained after adjusting for age and body size (height, weight, and bone area). Multiple linear regression analysis including the other known covariates (lean body mass, PA, energy adjusted calcium, and follow-up time) showed that soy isoflavones, together with these variables, accounted for 24% of the variances of the SBMD individual regression slope. This longitudinal study shows that soy intake had a significant effect on the maintenance of SBMD in women aged 30-40 years. The effects of phytoestrogens on bone health should be explored further in a population with habitual dietary soy but low calcium intake.

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  • Authors+Show Affiliations

    ,

    Department of Community and Family Medicine, The Chinese University of Hong Kong.

    , , ,

    Source

    MeSH

    Absorptiometry, Photon
    Adult
    Aging
    Asian Continental Ancestry Group
    Body Constitution
    Bone Density
    Calcium, Dietary
    Diet
    Female
    Follow-Up Studies
    Hong Kong
    Humans
    Isoflavones
    Organ Size
    Plants, Medicinal
    Premenopause
    Regression Analysis
    Soybeans
    Spine

    Pub Type(s)

    Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11450713

    Citation

    Ho, S C., et al. "Soy Intake and the Maintenance of Peak Bone Mass in Hong Kong Chinese Women." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 16, no. 7, 2001, pp. 1363-9.
    Ho SC, Chan SG, Yi Q, et al. Soy intake and the maintenance of peak bone mass in Hong Kong Chinese women. J Bone Miner Res. 2001;16(7):1363-9.
    Ho, S. C., Chan, S. G., Yi, Q., Wong, E., & Leung, P. C. (2001). Soy intake and the maintenance of peak bone mass in Hong Kong Chinese women. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 16(7), pp. 1363-9.
    Ho SC, et al. Soy Intake and the Maintenance of Peak Bone Mass in Hong Kong Chinese Women. J Bone Miner Res. 2001;16(7):1363-9. PubMed PMID: 11450713.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Soy intake and the maintenance of peak bone mass in Hong Kong Chinese women. AU - Ho,S C, AU - Chan,S G, AU - Yi,Q, AU - Wong,E, AU - Leung,P C, PY - 2001/7/14/pubmed PY - 2002/1/19/medline PY - 2001/7/14/entrez SP - 1363 EP - 9 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 16 IS - 7 N2 - Our previous study on bone health among premenopausal women showed that bone mass consolidation is attained by the early 30s, and small loss of spinal bone mineral density (SBMD) occurs soon after peak bone mass attainment. Recent interest has been shown in the potential beneficial effects of phytoestrogens on bone health. However, data are lacking, particularly in Asian women. This study aims to investigate the effect of soy isoflavones intake on the maintenance of peak bone mass in a cohort of 132 women aged 30-40 years who were followed up for 3 years. Baseline measurements of SBMD (L2-L4) were obtained using dual-energy X-ray densitometry, and dietary intake of soy foods and other key nutrients, including dietary calcium, were obtained through a quantitative food frequency method. Information on body measurements; physical activity (PA), weight-bearing activity in particular; age of menarche; and number of pregnancies were obtained at baseline. Repeated measurements of SBMD were obtained yearly for a further 3 years with an average follow-up time of 38 months. Analyses were performed on 116 subjects with at least three SBMD measurements (at baseline, 3-year follow-up, and at least one measurement during follow-up). The individual SBMD regression slope was computed for each of the subjects. Soy isoflavones consumption was categorized as quartiles of intake. We observed a significant difference in the SBMD individual regression slopes between women belonging to the fourth and first soy isoflavones intake quartiles. The positive effect of soy isoflavones on SBMD remained after adjusting for age and body size (height, weight, and bone area). Multiple linear regression analysis including the other known covariates (lean body mass, PA, energy adjusted calcium, and follow-up time) showed that soy isoflavones, together with these variables, accounted for 24% of the variances of the SBMD individual regression slope. This longitudinal study shows that soy intake had a significant effect on the maintenance of SBMD in women aged 30-40 years. The effects of phytoestrogens on bone health should be explored further in a population with habitual dietary soy but low calcium intake. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/11450713/Soy_intake_and_the_maintenance_of_peak_bone_mass_in_Hong_Kong_Chinese_women_ L2 - https://doi.org/10.1359/jbmr.2001.16.7.1363 DB - PRIME DP - Unbound Medicine ER -