Tags

Type your tag names separated by a space and hit enter

Perinatal metabolism of dichlorodiphenyldichloroethylene in Nicaraguan mothers.
Environ Res. 2001 Jul; 86(3):229-37.ER

Abstract

Umbilical cord and venous blood samples were collected at the time of delivery from 52 mothers living in urban and rural areas of the Atoya River basin, Nicaragua. In a subsample of 24 mothers that delivered by Cesarean section, abdominal adipose tissue samples were also collected, as was breast milk later in lactation. Cord and venous blood sera were analyzed for 13 organochlorine pesticides: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (pp'-DDT); 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (pp'-DDE); pp'-dichlorophenyldichlorodiene (pp'-DDD); alpha-hexachlorocyclohexane (alpha-HCH); beta-hexachlorocyclohexane (beta-HCH); gamma-hexachlorocyclohexane (gamma-HCH); delta-hexachlorocyclohexane (delta-HCH); toxaphene; dieldrin; endrin; aldrin; heptachlor; and heptachlor epoxide. In venous blood only pp'-DDE (100% of samples), pp'-DDT (1.92%), dieldrin (15.38%), heptachlor (15.38%), gamma-HCH (7.69%), beta-HCH (11.53%), and delta-HCH (1.92%) were found, whereas in cord blood only pp'-DDE (100%), pp'-DDT (3.84%), dieldrin (19.23%), and heptachlor (9.16%), were found. The persistent DDT metabolite pp'-DDE, present in all samples of blood serum, adipose tissue, and breast milk, was studied in relation to maternal characteristics such as body mass index (BMI), age, lactation experience, and fetal pesticide acquisition. Mean venous (7.12 microg/g) and cord (6.39 microg/g) pp'-DDE concentrations were not significantly different but were significantly correlated. pp'-DDE in maternal adipose tissue was positively correlated with pp'-DDE in cord blood (P=0.0001) and breast milk (P<0.0001) and marginally correlated with changes in BMI (r=-0.03088; P=0.06). There was a higher proportion of samples (58%) with a greater concentration of DDE in venous than in cord blood. Although DDE accumulation may be less during fetal development than during breast feeding, exposure during embryogenesis may be more important than during the postnatal period.

Authors+Show Affiliations

Department of Nutrition and Department of Chemistry, Universidade de Brasilia, Brasilia, 70919, Brazil. dorea@rudah.com.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11453673

Citation

Dorea, J G., et al. "Perinatal Metabolism of Dichlorodiphenyldichloroethylene in Nicaraguan Mothers." Environmental Research, vol. 86, no. 3, 2001, pp. 229-37.
Dorea JG, Cruz-Granja AC, Lacayo-Romero ML, et al. Perinatal metabolism of dichlorodiphenyldichloroethylene in Nicaraguan mothers. Environ Res. 2001;86(3):229-37.
Dorea, J. G., Cruz-Granja, A. C., Lacayo-Romero, M. L., & Cuadra-Leal, J. (2001). Perinatal metabolism of dichlorodiphenyldichloroethylene in Nicaraguan mothers. Environmental Research, 86(3), 229-37.
Dorea JG, et al. Perinatal Metabolism of Dichlorodiphenyldichloroethylene in Nicaraguan Mothers. Environ Res. 2001;86(3):229-37. PubMed PMID: 11453673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perinatal metabolism of dichlorodiphenyldichloroethylene in Nicaraguan mothers. AU - Dorea,J G, AU - Cruz-Granja,A C, AU - Lacayo-Romero,M L, AU - Cuadra-Leal,J, PY - 2001/7/17/pubmed PY - 2001/8/3/medline PY - 2001/7/17/entrez SP - 229 EP - 37 JF - Environmental research JO - Environ Res VL - 86 IS - 3 N2 - Umbilical cord and venous blood samples were collected at the time of delivery from 52 mothers living in urban and rural areas of the Atoya River basin, Nicaragua. In a subsample of 24 mothers that delivered by Cesarean section, abdominal adipose tissue samples were also collected, as was breast milk later in lactation. Cord and venous blood sera were analyzed for 13 organochlorine pesticides: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (pp'-DDT); 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (pp'-DDE); pp'-dichlorophenyldichlorodiene (pp'-DDD); alpha-hexachlorocyclohexane (alpha-HCH); beta-hexachlorocyclohexane (beta-HCH); gamma-hexachlorocyclohexane (gamma-HCH); delta-hexachlorocyclohexane (delta-HCH); toxaphene; dieldrin; endrin; aldrin; heptachlor; and heptachlor epoxide. In venous blood only pp'-DDE (100% of samples), pp'-DDT (1.92%), dieldrin (15.38%), heptachlor (15.38%), gamma-HCH (7.69%), beta-HCH (11.53%), and delta-HCH (1.92%) were found, whereas in cord blood only pp'-DDE (100%), pp'-DDT (3.84%), dieldrin (19.23%), and heptachlor (9.16%), were found. The persistent DDT metabolite pp'-DDE, present in all samples of blood serum, adipose tissue, and breast milk, was studied in relation to maternal characteristics such as body mass index (BMI), age, lactation experience, and fetal pesticide acquisition. Mean venous (7.12 microg/g) and cord (6.39 microg/g) pp'-DDE concentrations were not significantly different but were significantly correlated. pp'-DDE in maternal adipose tissue was positively correlated with pp'-DDE in cord blood (P=0.0001) and breast milk (P<0.0001) and marginally correlated with changes in BMI (r=-0.03088; P=0.06). There was a higher proportion of samples (58%) with a greater concentration of DDE in venous than in cord blood. Although DDE accumulation may be less during fetal development than during breast feeding, exposure during embryogenesis may be more important than during the postnatal period. SN - 0013-9351 UR - https://www.unboundmedicine.com/medline/citation/11453673/Perinatal_metabolism_of_dichlorodiphenyldichloroethylene_in_Nicaraguan_mothers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(01)94277-X DB - PRIME DP - Unbound Medicine ER -