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Necrotizing infundibular crystalline folliculitis.
Br J Dermatol. 2001 Jul; 145(1):165-8.BJ

Abstract

We describe a 22-year-old woman with a background of acne who developed multiple folliculocentric facial papules associated with sharply demarcated waxy, keratotic plugs. Multiple skin biopsies showed umbilicated craters that were filled with dispersed bundles of eosinophilic filaments embedded in a pale amorphous matrix forming a plug. The plugs bulged into the upper dermis. Serial sections showed vacuolar and filamentous destruction of the infundibular and adjacent perifollicular epithelium and a close relationship of the crystalline necrosis to follicles. Electron microscopy revealed that the filamentous bundles were tonofilaments. No fresh material was available for polarization and the paraffin sections failed to polarize. The clinical and pathological findings of the lesions in our patient were identical to those reported as a new perforating disorder with urate-like crystals. Our case indicates that the process may represent crystalline folliculocentric necrosis rather than a primary perforating disorder. The nature and basis of the crystals that have a urate-like appearance remain to be determined.

Authors+Show Affiliations

Skin and Cancer Foundation Australia, 277 Bourke Street, Darlinghurst, NSW 2010, Australia. kossards@zip.com.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11453930

Citation

Kossard, S, et al. "Necrotizing Infundibular Crystalline Folliculitis." The British Journal of Dermatology, vol. 145, no. 1, 2001, pp. 165-8.
Kossard S, Scurry J, Killingsworth M. Necrotizing infundibular crystalline folliculitis. Br J Dermatol. 2001;145(1):165-8.
Kossard, S., Scurry, J., & Killingsworth, M. (2001). Necrotizing infundibular crystalline folliculitis. The British Journal of Dermatology, 145(1), 165-8.
Kossard S, Scurry J, Killingsworth M. Necrotizing Infundibular Crystalline Folliculitis. Br J Dermatol. 2001;145(1):165-8. PubMed PMID: 11453930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrotizing infundibular crystalline folliculitis. AU - Kossard,S, AU - Scurry,J, AU - Killingsworth,M, PY - 2001/7/17/pubmed PY - 2001/9/8/medline PY - 2001/7/17/entrez SP - 165 EP - 8 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 145 IS - 1 N2 - We describe a 22-year-old woman with a background of acne who developed multiple folliculocentric facial papules associated with sharply demarcated waxy, keratotic plugs. Multiple skin biopsies showed umbilicated craters that were filled with dispersed bundles of eosinophilic filaments embedded in a pale amorphous matrix forming a plug. The plugs bulged into the upper dermis. Serial sections showed vacuolar and filamentous destruction of the infundibular and adjacent perifollicular epithelium and a close relationship of the crystalline necrosis to follicles. Electron microscopy revealed that the filamentous bundles were tonofilaments. No fresh material was available for polarization and the paraffin sections failed to polarize. The clinical and pathological findings of the lesions in our patient were identical to those reported as a new perforating disorder with urate-like crystals. Our case indicates that the process may represent crystalline folliculocentric necrosis rather than a primary perforating disorder. The nature and basis of the crystals that have a urate-like appearance remain to be determined. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/11453930/Necrotizing_infundibular_crystalline_folliculitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=2001&volume=145&issue=1&spage=165 DB - PRIME DP - Unbound Medicine ER -