Tags

Type your tag names separated by a space and hit enter

Chronic hepatitis C and superimposed nonalcoholic fatty liver disease.
Liver 2001; 21(4):266-71L

Abstract

BACKGROUND/AIMS

Hepatitis C and nonalcoholic fatty liver disease (NAFL) are the two most common forms of liver disease in the United States. Recently, obesity and its associated risk factors have been suggested to enhance HCV-related fibrosis. The aim of this study was to assess the impact of hepatic steatosis, steatohepatitis, and its associated risk factors on HCV-related fibrosis.

METHODS

Patients with untreated, biopsy-proven, chronic hepatitis C (6/97-3/99) were included. Clinical and demographic data at the time of liver biopsy were obtained from chart review and verified by telephone survey. One hepatopathologist reviewed all pathologic specimens, using the modified histological activity index score and the Ishak staging for fibrosis and a NAFL pathologic protocol.

RESULTS

One hundred and seventy patients with hepatitis C were included [age: 48.7+/-9.33 (years), body mass index (BMI): 28.1+/-5.7 (kg/m2) and type 2 diabetes mellitus (DM): 14%]. Of these, 77 (45.3%) had no or mild fibrosis and 93 (54.7%) had advanced fibrosis. Hepatic steatosis was seen in 90 (52.9%) patients. The grade of steatosis was associated with markers of obesity only. Age (p=0.002), type 2 DM (p=0.04), and superimposed steatohepatitis (p=0.047) were independently associated with advanced fibrosis. Superimposed nonalcoholic steatohepatitis (NASH) was seen in 17 (10%) patients. Patients with superimposed NASH were mostly obese (76.5%), males (62%) with 16% having type 2 diabetes and a BMI 33.8+/-7.12.

CONCLUSION

In patients with chronic hepatitis C, type 2 DM and superimposed steatohepatitis are independently associated with advanced fibrosis.

Authors+Show Affiliations

Department of Gastroenterology and Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11454190

Citation

Ong, J P., et al. "Chronic Hepatitis C and Superimposed Nonalcoholic Fatty Liver Disease." Liver, vol. 21, no. 4, 2001, pp. 266-71.
Ong JP, Younossi ZM, Speer C, et al. Chronic hepatitis C and superimposed nonalcoholic fatty liver disease. Liver. 2001;21(4):266-71.
Ong, J. P., Younossi, Z. M., Speer, C., Olano, A., Gramlich, T., & Boparai, N. (2001). Chronic hepatitis C and superimposed nonalcoholic fatty liver disease. Liver, 21(4), pp. 266-71.
Ong JP, et al. Chronic Hepatitis C and Superimposed Nonalcoholic Fatty Liver Disease. Liver. 2001;21(4):266-71. PubMed PMID: 11454190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic hepatitis C and superimposed nonalcoholic fatty liver disease. AU - Ong,J P, AU - Younossi,Z M, AU - Speer,C, AU - Olano,A, AU - Gramlich,T, AU - Boparai,N, PY - 2001/7/17/pubmed PY - 2001/11/3/medline PY - 2001/7/17/entrez SP - 266 EP - 71 JF - Liver JO - Liver VL - 21 IS - 4 N2 - BACKGROUND/AIMS: Hepatitis C and nonalcoholic fatty liver disease (NAFL) are the two most common forms of liver disease in the United States. Recently, obesity and its associated risk factors have been suggested to enhance HCV-related fibrosis. The aim of this study was to assess the impact of hepatic steatosis, steatohepatitis, and its associated risk factors on HCV-related fibrosis. METHODS: Patients with untreated, biopsy-proven, chronic hepatitis C (6/97-3/99) were included. Clinical and demographic data at the time of liver biopsy were obtained from chart review and verified by telephone survey. One hepatopathologist reviewed all pathologic specimens, using the modified histological activity index score and the Ishak staging for fibrosis and a NAFL pathologic protocol. RESULTS: One hundred and seventy patients with hepatitis C were included [age: 48.7+/-9.33 (years), body mass index (BMI): 28.1+/-5.7 (kg/m2) and type 2 diabetes mellitus (DM): 14%]. Of these, 77 (45.3%) had no or mild fibrosis and 93 (54.7%) had advanced fibrosis. Hepatic steatosis was seen in 90 (52.9%) patients. The grade of steatosis was associated with markers of obesity only. Age (p=0.002), type 2 DM (p=0.04), and superimposed steatohepatitis (p=0.047) were independently associated with advanced fibrosis. Superimposed nonalcoholic steatohepatitis (NASH) was seen in 17 (10%) patients. Patients with superimposed NASH were mostly obese (76.5%), males (62%) with 16% having type 2 diabetes and a BMI 33.8+/-7.12. CONCLUSION: In patients with chronic hepatitis C, type 2 DM and superimposed steatohepatitis are independently associated with advanced fibrosis. SN - 0106-9543 UR - https://www.unboundmedicine.com/medline/citation/11454190/Chronic_hepatitis_C_and_superimposed_nonalcoholic_fatty_liver_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0106-9543&date=2001&volume=21&issue=4&spage=266 DB - PRIME DP - Unbound Medicine ER -