Tags

Type your tag names separated by a space and hit enter

Prospective study of caffeine consumption and risk of Parkinson's disease in men and women.
Ann Neurol 2001; 50(1):56-63AN

Abstract

Results of case-control studies and of a prospective investigation in men suggest that consumption of coffee could protect against the risk of Parkinson's disease, but the active constituent is not clear. To address the hypothesis that caffeine is protective against Parkinson's disease, we examined the relationship of coffee and caffeine consumption to the risk of this disease among participants in two ongoing cohorts, the Health Professionals' Follow-Up Study (HPFS) and the Nurses' Health Study (NHS). The study population comprised 47,351 men and 88,565 women who were free of Parkinson's disease, stroke, or cancer at baseline. A comprehensive life style and dietary questionnaire was completed by the participants at baseline and updated every two to four years. During the follow-up (10 years in men, 16 years in women), we documented a total of 288 incident cases of Parkinson's disease. Among men, after adjustment for age and smoking, the relative risk of Parkinson's disease was 0.42 (95% CI: 0.23-0.78; p for trend < 0.001) for men in the top one-fifth of caffeine intake compared to those in the bottom one-fifth. An inverse association was also observed with consumption of coffee (p for trend = 0.004), caffeine from noncoffee sources (p for trend < 0.001), and tea (p for trend = 0.02) but not decaffeinated coffee. Among women, the relationship between caffeine or coffee intake and risk of Parkinson's disease was U-shaped, with the lowest risk observed at moderate intakes (1-3 cups of coffee/day, or the third quintile of caffeine consumption). These results support a possible protective effect of moderate doses of caffeine on risk of Parkinson's disease.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. alberto.ascherio@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11456310

Citation

Ascherio, A, et al. "Prospective Study of Caffeine Consumption and Risk of Parkinson's Disease in Men and Women." Annals of Neurology, vol. 50, no. 1, 2001, pp. 56-63.
Ascherio A, Zhang SM, Hernán MA, et al. Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. Ann Neurol. 2001;50(1):56-63.
Ascherio, A., Zhang, S. M., Hernán, M. A., Kawachi, I., Colditz, G. A., Speizer, F. E., & Willett, W. C. (2001). Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. Annals of Neurology, 50(1), pp. 56-63.
Ascherio A, et al. Prospective Study of Caffeine Consumption and Risk of Parkinson's Disease in Men and Women. Ann Neurol. 2001;50(1):56-63. PubMed PMID: 11456310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. AU - Ascherio,A, AU - Zhang,S M, AU - Hernán,M A, AU - Kawachi,I, AU - Colditz,G A, AU - Speizer,F E, AU - Willett,W C, PY - 2001/7/18/pubmed PY - 2002/1/5/medline PY - 2001/7/18/entrez SP - 56 EP - 63 JF - Annals of neurology JO - Ann. Neurol. VL - 50 IS - 1 N2 - Results of case-control studies and of a prospective investigation in men suggest that consumption of coffee could protect against the risk of Parkinson's disease, but the active constituent is not clear. To address the hypothesis that caffeine is protective against Parkinson's disease, we examined the relationship of coffee and caffeine consumption to the risk of this disease among participants in two ongoing cohorts, the Health Professionals' Follow-Up Study (HPFS) and the Nurses' Health Study (NHS). The study population comprised 47,351 men and 88,565 women who were free of Parkinson's disease, stroke, or cancer at baseline. A comprehensive life style and dietary questionnaire was completed by the participants at baseline and updated every two to four years. During the follow-up (10 years in men, 16 years in women), we documented a total of 288 incident cases of Parkinson's disease. Among men, after adjustment for age and smoking, the relative risk of Parkinson's disease was 0.42 (95% CI: 0.23-0.78; p for trend < 0.001) for men in the top one-fifth of caffeine intake compared to those in the bottom one-fifth. An inverse association was also observed with consumption of coffee (p for trend = 0.004), caffeine from noncoffee sources (p for trend < 0.001), and tea (p for trend = 0.02) but not decaffeinated coffee. Among women, the relationship between caffeine or coffee intake and risk of Parkinson's disease was U-shaped, with the lowest risk observed at moderate intakes (1-3 cups of coffee/day, or the third quintile of caffeine consumption). These results support a possible protective effect of moderate doses of caffeine on risk of Parkinson's disease. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/11456310/Prospective_study_of_caffeine_consumption_and_risk_of_Parkinson's_disease_in_men_and_women_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0364-5134&amp;date=2001&amp;volume=50&amp;issue=1&amp;spage=56 DB - PRIME DP - Unbound Medicine ER -