Tags

Type your tag names separated by a space and hit enter

Diagnostic value of D dimer in pulmonary embolism and pneumonia.
Respiration. 2001; 68(4):371-5.R

Abstract

BACKGROUND

Diagnosis of pulmonary embolism (PE) and its clear-cut differentiation with other entities of occasional similar presentation remains difficult in routine clinical practice. High plasmatic levels of D dimer (DD), a specific fibrin derivate, have recently been reported in PE.

OBJECTIVE

The purpose of this study was to prospectively evaluate the diagnostic value of plasmatic DD in a clinical setting.

METHODS

We studied 52 patients with PE proven with pulmonary scintigraphic studies in relation to 19 patients posteriorly diagnosed of having community-acquired pneumonia and 30 healthy subjects. Evolution of DD levels whilst the patients were on intravenous anticoagulant therapy was evaluated by measuring DD concentration on admission and on day 7 in 10 patients.

RESULTS

Plasma DD levels were significantly higher in PE in relation to controls (p < 0.001). DD levels were also higher in patients diagnosed with community-acquired pneumonia in relation to controls (p < 0.05) but lower than those obtained in high probability PE (p < 0.05). Sensitivity and specificity of plasmatic DD in the emergency diagnosis of PE are of 92 and 71%, respectively. Plasma levels of DD were found to progressively decrease during the first week of heparin therapy, but they remained higher than in control subjects.

CONCLUSIONS

Plasma DD levels are increased in patients with suspected PE and the degree of elevation is related to the results obtained in scintiscans. Moreover, DD concentrations progressively decrease during the first week of anticoagulant therapy. The increased DD levels found in patients with pneumonia make this test useless in the differential diagnosis between these two clinical entities.

Authors+Show Affiliations

Servicio de Urgencias, Hospital Ramón y Cajal, E-28080 Madrid, Spain. djc_69_98@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11464083

Citation

Castro, D J., et al. "Diagnostic Value of D Dimer in Pulmonary Embolism and Pneumonia." Respiration; International Review of Thoracic Diseases, vol. 68, no. 4, 2001, pp. 371-5.
Castro DJ, Pérez-Rodríguez E, Montaner L, et al. Diagnostic value of D dimer in pulmonary embolism and pneumonia. Respiration. 2001;68(4):371-5.
Castro, D. J., Pérez-Rodríguez, E., Montaner, L., Flores, J., & Nuevo, G. D. (2001). Diagnostic value of D dimer in pulmonary embolism and pneumonia. Respiration; International Review of Thoracic Diseases, 68(4), 371-5.
Castro DJ, et al. Diagnostic Value of D Dimer in Pulmonary Embolism and Pneumonia. Respiration. 2001;68(4):371-5. PubMed PMID: 11464083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic value of D dimer in pulmonary embolism and pneumonia. AU - Castro,D J, AU - Pérez-Rodríguez,E, AU - Montaner,L, AU - Flores,J, AU - Nuevo,G D, PY - 2001/7/21/pubmed PY - 2001/10/5/medline PY - 2001/7/21/entrez SP - 371 EP - 5 JF - Respiration; international review of thoracic diseases JO - Respiration VL - 68 IS - 4 N2 - BACKGROUND: Diagnosis of pulmonary embolism (PE) and its clear-cut differentiation with other entities of occasional similar presentation remains difficult in routine clinical practice. High plasmatic levels of D dimer (DD), a specific fibrin derivate, have recently been reported in PE. OBJECTIVE: The purpose of this study was to prospectively evaluate the diagnostic value of plasmatic DD in a clinical setting. METHODS: We studied 52 patients with PE proven with pulmonary scintigraphic studies in relation to 19 patients posteriorly diagnosed of having community-acquired pneumonia and 30 healthy subjects. Evolution of DD levels whilst the patients were on intravenous anticoagulant therapy was evaluated by measuring DD concentration on admission and on day 7 in 10 patients. RESULTS: Plasma DD levels were significantly higher in PE in relation to controls (p < 0.001). DD levels were also higher in patients diagnosed with community-acquired pneumonia in relation to controls (p < 0.05) but lower than those obtained in high probability PE (p < 0.05). Sensitivity and specificity of plasmatic DD in the emergency diagnosis of PE are of 92 and 71%, respectively. Plasma levels of DD were found to progressively decrease during the first week of heparin therapy, but they remained higher than in control subjects. CONCLUSIONS: Plasma DD levels are increased in patients with suspected PE and the degree of elevation is related to the results obtained in scintiscans. Moreover, DD concentrations progressively decrease during the first week of anticoagulant therapy. The increased DD levels found in patients with pneumonia make this test useless in the differential diagnosis between these two clinical entities. SN - 0025-7931 UR - https://www.unboundmedicine.com/medline/citation/11464083/Diagnostic_value_of_D_dimer_in_pulmonary_embolism_and_pneumonia_ L2 - https://www.karger.com?DOI=10.1159/000050529 DB - PRIME DP - Unbound Medicine ER -