Tags

Type your tag names separated by a space and hit enter

Are adverse effects of sildenafil also caused by inhibition of diamine oxidase?
Urol Int. 2001; 67(1):59-61.UI

Abstract

BACKGROUND

Sildenafil citrate (Viagra), a drug used to treat erectile dysfunctions, causes adverse reactions such as headache, flushing or nasal congestion. Sildanefil's potency as inhibitor of diamine oxidase was investigated, as side effects may also be induced by histamine itself due to an impaired histamine metabolism.

METHODS

Placental diamine oxidase inhibition experiments were performed with consecutive dilutions of sildenafil citrate (10(-5) to 10(-9) mol/l). In 9 male volunteers in vivo diamine oxidase inhibition was investigated after taking 100 mg sildenafil (Viagra).

RESULTS

Sildenafil citrate did not inhibit placental diamine oxidase either in vitro or in vivo. However, infusion of 300 mg of cimetidine inhibited diamine oxidase activity by 27 +/- 7% 15 min after infusion, demonstrating that drugs may inhibit diamine oxidase in vivo.

CONCLUSION

As side effects of sildenafil are not caused due to inhibition of diamine oxidase, sildenafil citrate seems to be harmless for patients suffering from histamine intolerance.

Authors+Show Affiliations

FAZ - Floridsdorfer Allergy Center, Rudolfstiftung, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11464118

Citation

Wantke, F, et al. "Are Adverse Effects of Sildenafil Also Caused By Inhibition of Diamine Oxidase?" Urologia Internationalis, vol. 67, no. 1, 2001, pp. 59-61.
Wantke F, Hemmer W, Focke M, et al. Are adverse effects of sildenafil also caused by inhibition of diamine oxidase? Urol Int. 2001;67(1):59-61.
Wantke, F., Hemmer, W., Focke, M., Stackl, W., Götz, M., & Jarisch, R. (2001). Are adverse effects of sildenafil also caused by inhibition of diamine oxidase? Urologia Internationalis, 67(1), 59-61.
Wantke F, et al. Are Adverse Effects of Sildenafil Also Caused By Inhibition of Diamine Oxidase. Urol Int. 2001;67(1):59-61. PubMed PMID: 11464118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are adverse effects of sildenafil also caused by inhibition of diamine oxidase? AU - Wantke,F, AU - Hemmer,W, AU - Focke,M, AU - Stackl,W, AU - Götz,M, AU - Jarisch,R, PY - 2001/7/21/pubmed PY - 2002/2/13/medline PY - 2001/7/21/entrez SP - 59 EP - 61 JF - Urologia internationalis JO - Urol. Int. VL - 67 IS - 1 N2 - BACKGROUND: Sildenafil citrate (Viagra), a drug used to treat erectile dysfunctions, causes adverse reactions such as headache, flushing or nasal congestion. Sildanefil's potency as inhibitor of diamine oxidase was investigated, as side effects may also be induced by histamine itself due to an impaired histamine metabolism. METHODS: Placental diamine oxidase inhibition experiments were performed with consecutive dilutions of sildenafil citrate (10(-5) to 10(-9) mol/l). In 9 male volunteers in vivo diamine oxidase inhibition was investigated after taking 100 mg sildenafil (Viagra). RESULTS: Sildenafil citrate did not inhibit placental diamine oxidase either in vitro or in vivo. However, infusion of 300 mg of cimetidine inhibited diamine oxidase activity by 27 +/- 7% 15 min after infusion, demonstrating that drugs may inhibit diamine oxidase in vivo. CONCLUSION: As side effects of sildenafil are not caused due to inhibition of diamine oxidase, sildenafil citrate seems to be harmless for patients suffering from histamine intolerance. SN - 0042-1138 UR - https://www.unboundmedicine.com/medline/citation/11464118/Are_adverse_effects_of_sildenafil_also_caused_by_inhibition_of_diamine_oxidase L2 - https://www.karger.com?DOI=10.1159/000050946 DB - PRIME DP - Unbound Medicine ER -