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Serum cystatin C is an independent predictor of total homocysteine levels in stable Korean renal transplant recipients with normal serum creatinine.
J Ren Nutr 2001; 11(3):149-54JR

Abstract

OBJECTIVES

To examine the determinants of fasting plasma total homocysteine (tHcy) levels such as cystatin C, serum creatinine (SCr), estimated glomerular filtration rate (GFR) from Cockroft-Gault equation, albumin, plasma folate, vitamin B12, and pyridoxal-5'-phosphate (PLP) among Korean renal transplant recipients (RTR) with normal SCr levels (< or =1.4 mg/dL).

DESIGN

Cross-sectional study.

SETTING

Nephrology and Transplant Service, Catholic University Kangnam St. Mary's Hospital, Seoul, Korea.

PARTICIPANTS

Fifty-one chronic stable Korean RTR with normal SCr levels (< or =1.4 mg/dL) 6 months or more following transplantation.

MEASURES

Medical record review, anthropometric measurements, and overnight (10 to 14 hours) fasting blood samples for measurement of plasma tHcy, folate, vitamin B12, PLP, SCr, albumin, and cystatin C.

RESULTS

General linear regression model including age, gender, vitamin status, and measurements of renal function showed that cystatin C and folate were independent predictors of tHcy levels. The partial regression coefficient for folate was -0.444 (P <.01) and for cystatin C, it was +0.334 (P <.05). SCr, estimated GFR, vitamin B12, PLP, age, and gender were not independent predictors of tHcy levels in this model.

CONCLUSION

Both cystatin C and folate status were major independent determinants of fasting tHcy levels in the subgroup of Korean RTR with normal SCr.

Authors+Show Affiliations

Frances Stern Nutrition Center, New England Medical Center, Boston, MA 02111, USA. hhan@world.std.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11466665

Citation

Han, H, et al. "Serum Cystatin C Is an Independent Predictor of Total Homocysteine Levels in Stable Korean Renal Transplant Recipients With Normal Serum Creatinine." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 11, no. 3, 2001, pp. 149-54.
Han H, Dwyer JT, Selhub J, et al. Serum cystatin C is an independent predictor of total homocysteine levels in stable Korean renal transplant recipients with normal serum creatinine. J Ren Nutr. 2001;11(3):149-54.
Han, H., Dwyer, J. T., Selhub, J., Jacques, P. F., Houser, R. F., Park, J. H., ... Bostom, A. G. (2001). Serum cystatin C is an independent predictor of total homocysteine levels in stable Korean renal transplant recipients with normal serum creatinine. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 11(3), pp. 149-54.
Han H, et al. Serum Cystatin C Is an Independent Predictor of Total Homocysteine Levels in Stable Korean Renal Transplant Recipients With Normal Serum Creatinine. J Ren Nutr. 2001;11(3):149-54. PubMed PMID: 11466665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cystatin C is an independent predictor of total homocysteine levels in stable Korean renal transplant recipients with normal serum creatinine. AU - Han,H, AU - Dwyer,J T, AU - Selhub,J, AU - Jacques,P F, AU - Houser,R F, AU - Park,J H, AU - Kim,Y S, AU - Bang,B K, AU - Kim,S, AU - Jung,K A, AU - Chang,Y K, AU - Bostom,A G, PY - 2001/7/24/pubmed PY - 2001/8/31/medline PY - 2001/7/24/entrez SP - 149 EP - 54 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 11 IS - 3 N2 - OBJECTIVES: To examine the determinants of fasting plasma total homocysteine (tHcy) levels such as cystatin C, serum creatinine (SCr), estimated glomerular filtration rate (GFR) from Cockroft-Gault equation, albumin, plasma folate, vitamin B12, and pyridoxal-5'-phosphate (PLP) among Korean renal transplant recipients (RTR) with normal SCr levels (< or =1.4 mg/dL). DESIGN: Cross-sectional study. SETTING: Nephrology and Transplant Service, Catholic University Kangnam St. Mary's Hospital, Seoul, Korea. PARTICIPANTS: Fifty-one chronic stable Korean RTR with normal SCr levels (< or =1.4 mg/dL) 6 months or more following transplantation. MEASURES: Medical record review, anthropometric measurements, and overnight (10 to 14 hours) fasting blood samples for measurement of plasma tHcy, folate, vitamin B12, PLP, SCr, albumin, and cystatin C. RESULTS: General linear regression model including age, gender, vitamin status, and measurements of renal function showed that cystatin C and folate were independent predictors of tHcy levels. The partial regression coefficient for folate was -0.444 (P <.01) and for cystatin C, it was +0.334 (P <.05). SCr, estimated GFR, vitamin B12, PLP, age, and gender were not independent predictors of tHcy levels in this model. CONCLUSION: Both cystatin C and folate status were major independent determinants of fasting tHcy levels in the subgroup of Korean RTR with normal SCr. SN - 1051-2276 UR - https://www.unboundmedicine.com/medline/citation/11466665/Serum_cystatin_C_is_an_independent_predictor_of_total_homocysteine_levels_in_stable_Korean_renal_transplant_recipients_with_normal_serum_creatinine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051227601276432 DB - PRIME DP - Unbound Medicine ER -