Tags

Type your tag names separated by a space and hit enter

Gender-related differences in IBS symptoms.
Am J Gastroenterol 2001; 96(7):2184-93AJ

Abstract

OBJECTIVE

Women are more likely than men to report irritable bowel syndrome (IBS) symptoms as well as chronic visceral and musculoskeletal pain. The study tests the general hypothesis that female IBS patients differ from their male counterparts in symptoms related to the viscera and musculoskeletal system, and that these differences are related to the menstrual cycle.

METHODS

Seven hundred fourteen Rome positive IBS patients were evaluated for GI and extracolonic symptoms, psychological symptoms (SCL-90R), and quality of life (QOL) (SF-36). In addition, 54 postmenopausal women were compared with 61 premenopausal women and 54 age-matched males, all with IBS.

RESULTS

Male and female subjects reported similar GI levels of symptom severity and psychological problems. Abdominal distension associated with a sensation of bloating was more commonly reported by female patients, as were symptoms of constipation. Female patients more often reported nausea, alterations of taste and smell, and unpleasant sensations on the tongue, muscle stiffness in the morning, greater food sensitivity, and side effects from medications. Forty percent of female patients reported menstrual cycle-related worsening of symptoms, but few symptom differences were found between pre- and postmenopausal women, making it unlikely that most of the gender differences observed are directly tied to the menstrual cycle.

CONCLUSIONS

Female patients report higher levels of a variety of intestinal and nonintestinal sensory symptoms despite similar levels of IBS severity, abdominal pain, psychological symptoms, and illness impact. The apparent differences in sensitivity to nonpainful visceral sensations, medications, and food may represent altered sensory processes, autonomic responses, and/or cognitive hypervigilance.

Authors+Show Affiliations

CURE Digestive Diseases Research Center/Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11467651

Citation

Lee, O Y., et al. "Gender-related Differences in IBS Symptoms." The American Journal of Gastroenterology, vol. 96, no. 7, 2001, pp. 2184-93.
Lee OY, Mayer EA, Schmulson M, et al. Gender-related differences in IBS symptoms. Am J Gastroenterol. 2001;96(7):2184-93.
Lee, O. Y., Mayer, E. A., Schmulson, M., Chang, L., & Naliboff, B. (2001). Gender-related differences in IBS symptoms. The American Journal of Gastroenterology, 96(7), pp. 2184-93.
Lee OY, et al. Gender-related Differences in IBS Symptoms. Am J Gastroenterol. 2001;96(7):2184-93. PubMed PMID: 11467651.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender-related differences in IBS symptoms. AU - Lee,O Y, AU - Mayer,E A, AU - Schmulson,M, AU - Chang,L, AU - Naliboff,B, PY - 2001/7/27/pubmed PY - 2001/8/31/medline PY - 2001/7/27/entrez SP - 2184 EP - 93 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 96 IS - 7 N2 - OBJECTIVE: Women are more likely than men to report irritable bowel syndrome (IBS) symptoms as well as chronic visceral and musculoskeletal pain. The study tests the general hypothesis that female IBS patients differ from their male counterparts in symptoms related to the viscera and musculoskeletal system, and that these differences are related to the menstrual cycle. METHODS: Seven hundred fourteen Rome positive IBS patients were evaluated for GI and extracolonic symptoms, psychological symptoms (SCL-90R), and quality of life (QOL) (SF-36). In addition, 54 postmenopausal women were compared with 61 premenopausal women and 54 age-matched males, all with IBS. RESULTS: Male and female subjects reported similar GI levels of symptom severity and psychological problems. Abdominal distension associated with a sensation of bloating was more commonly reported by female patients, as were symptoms of constipation. Female patients more often reported nausea, alterations of taste and smell, and unpleasant sensations on the tongue, muscle stiffness in the morning, greater food sensitivity, and side effects from medications. Forty percent of female patients reported menstrual cycle-related worsening of symptoms, but few symptom differences were found between pre- and postmenopausal women, making it unlikely that most of the gender differences observed are directly tied to the menstrual cycle. CONCLUSIONS: Female patients report higher levels of a variety of intestinal and nonintestinal sensory symptoms despite similar levels of IBS severity, abdominal pain, psychological symptoms, and illness impact. The apparent differences in sensitivity to nonpainful visceral sensations, medications, and food may represent altered sensory processes, autonomic responses, and/or cognitive hypervigilance. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/11467651/Gender_related_differences_in_IBS_symptoms_ L2 - http://Insights.ovid.com/pubmed?pmid=11467651 DB - PRIME DP - Unbound Medicine ER -