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Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease.
Am J Clin Nutr 2001; 74(2):259-64AJ

Abstract

BACKGROUND

In Crohn disease (CD), the increased production of reactive oxygen species from activated neutrophils may reduce plasma concentrations of antioxidant vitamins and result in increased oxidative stress.

OBJECTIVE

We compared lipid peroxidation, a measure of reactive-oxygen-species production, and plasma antioxidant vitamin concentrations between CD patients and healthy control subjects.

DESIGN

Thirty-seven nonsmoking CD patients (22 women and 15 men) were compared with an equal number of healthy control subjects who were matched by age, sex, and body mass index. In patients the mean CD activity index (CDAI) was 141.2 +/- 18.7 (range: 9.0-514), and 11 of 37 patients (30%) had a CDAI > or =150. Seventy-eight percent of patients were taking > or = 1 medication. Medication use by subjects included the following: 5-aminosalicylic acid (40% of subjects), antibiotics (22%), oral corticosteroids (30%), and immunosuppressants (19%).

RESULTS

Lipid peroxidation as measured by breath pentane output (CD patients, 7.47 +/- 0.98 pmol x kg(-1) x min(-1); control subjects, 4.97 +/- 0.48 pmol x kg(-1) x min(-1); P < or = 0.025), breath ethane output (CD patients, 11.24 +/- 1.17 pmol x kg(-1) x min(-1); control subjects, 5.46 +/- 0.71 pmol x kg(-1) x min(-1); P < or = 0.0005) and F2-isoprostane (CD patients, 78.6 +/- 8.0 ng/L; control subjects, 60.6 +/- 3.7 ng/L; P < or = 0.047) were significantly higher in CD patients than in control subjects. Plasma antioxidant vitamins (ascorbic acid, alpha- and beta-carotene, lycopene, and beta-cryptoxanthin) were all significantly lower in CD patients than in control subjects. There were no significant differences in macro- and micronutrient intakes between groups.

CONCLUSION

Patients with CD are oxidatively stressed, which was observed even though 70% of patients had a CDAI < or =150 and 78% of them were taking medications to treat CD.

Authors+Show Affiliations

Division of Gastroenterology and Nutrition Research, Department of Medicine, Toronto General Hospital, University Health Network, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11470730

Citation

Wendland, B E., et al. "Lipid Peroxidation and Plasma Antioxidant Micronutrients in Crohn Disease." The American Journal of Clinical Nutrition, vol. 74, no. 2, 2001, pp. 259-64.
Wendland BE, Aghdassi E, Tam C, et al. Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease. Am J Clin Nutr. 2001;74(2):259-64.
Wendland, B. E., Aghdassi, E., Tam, C., Carrrier, J., Steinhart, A. H., Wolman, S. L., ... Allard, J. P. (2001). Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease. The American Journal of Clinical Nutrition, 74(2), pp. 259-64.
Wendland BE, et al. Lipid Peroxidation and Plasma Antioxidant Micronutrients in Crohn Disease. Am J Clin Nutr. 2001;74(2):259-64. PubMed PMID: 11470730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease. AU - Wendland,B E, AU - Aghdassi,E, AU - Tam,C, AU - Carrrier,J, AU - Steinhart,A H, AU - Wolman,S L, AU - Baron,D, AU - Allard,J P, PY - 2001/7/27/pubmed PY - 2001/8/24/medline PY - 2001/7/27/entrez SP - 259 EP - 64 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 74 IS - 2 N2 - BACKGROUND: In Crohn disease (CD), the increased production of reactive oxygen species from activated neutrophils may reduce plasma concentrations of antioxidant vitamins and result in increased oxidative stress. OBJECTIVE: We compared lipid peroxidation, a measure of reactive-oxygen-species production, and plasma antioxidant vitamin concentrations between CD patients and healthy control subjects. DESIGN: Thirty-seven nonsmoking CD patients (22 women and 15 men) were compared with an equal number of healthy control subjects who were matched by age, sex, and body mass index. In patients the mean CD activity index (CDAI) was 141.2 +/- 18.7 (range: 9.0-514), and 11 of 37 patients (30%) had a CDAI > or =150. Seventy-eight percent of patients were taking > or = 1 medication. Medication use by subjects included the following: 5-aminosalicylic acid (40% of subjects), antibiotics (22%), oral corticosteroids (30%), and immunosuppressants (19%). RESULTS: Lipid peroxidation as measured by breath pentane output (CD patients, 7.47 +/- 0.98 pmol x kg(-1) x min(-1); control subjects, 4.97 +/- 0.48 pmol x kg(-1) x min(-1); P < or = 0.025), breath ethane output (CD patients, 11.24 +/- 1.17 pmol x kg(-1) x min(-1); control subjects, 5.46 +/- 0.71 pmol x kg(-1) x min(-1); P < or = 0.0005) and F2-isoprostane (CD patients, 78.6 +/- 8.0 ng/L; control subjects, 60.6 +/- 3.7 ng/L; P < or = 0.047) were significantly higher in CD patients than in control subjects. Plasma antioxidant vitamins (ascorbic acid, alpha- and beta-carotene, lycopene, and beta-cryptoxanthin) were all significantly lower in CD patients than in control subjects. There were no significant differences in macro- and micronutrient intakes between groups. CONCLUSION: Patients with CD are oxidatively stressed, which was observed even though 70% of patients had a CDAI < or =150 and 78% of them were taking medications to treat CD. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/11470730/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/74.2.259 DB - PRIME DP - Unbound Medicine ER -