Tags

Type your tag names separated by a space and hit enter

Macrophage inflammatory protein-1alpha (not T helper type 2 cytokines) is associated with severe forms of respiratory syncytial virus bronchiolitis.
J Infect Dis. 2001 Aug 15; 184(4):393-9.JI

Abstract

It has been suggested that the pathogenesis of respiratory syncytial virus (RSV) infection is related to the development of T helper (Th) type 2 cytokine responses. The presence of Th1 and Th2 cytokines and the chemokines macrophage inflammatory protein (MIP)-1alpha and monocyte chemotactic protein (MCP)-1 were assessed by ELISA in nasopharyngeal secretions of infants with RSV infection. Infants with mild bronchiolitis had increased Th1 cytokines and reduced Th2 cytokines, compared with infants with upper respiratory tract illness alone. Severe bronchiolitis was characterized by a more balanced Th1-Th2 response that did not differ from that of infants with upper respiratory tract illness alone. In contrast, MIP-1alpha was markedly increased in infants with severe bronchiolitis. MIP-1alpha and MCP-1 levels also were inversely related to oxygen saturation (P<.005). Thus, the severity of RSV bronchiolitis appears to be related more to chemokine release than to Th2 cytokine production.

Links

Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Garofalo RP
Division of Immunology, Department of Pediatrics, University of Texas Medical Branch at Galveston, Galveston, TX 77550, USA. rpgarofa@utmb.edu
Patti J
No affiliation info available
Hintz KA
No affiliation info available
Hill V
No affiliation info available
Ogra PL
No affiliation info available
Welliver RC
No affiliation info available

MeSH

BronchiolitisChemokine CCL2Chemokine CCL3Chemokine CCL4Child, PreschoolCytokinesFemaleHumansInfantInfant, NewbornMacrophage Inflammatory ProteinsMaleNasopharynxRespiratory Syncytial Virus InfectionsRespiratory Syncytial VirusesTh1 CellsTh2 Cells

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11471095

Citation

Garofalo, R P., et al. "Macrophage Inflammatory Protein-1alpha (not T Helper Type 2 Cytokines) Is Associated With Severe Forms of Respiratory Syncytial Virus Bronchiolitis." The Journal of Infectious Diseases, vol. 184, no. 4, 2001, pp. 393-9.
Garofalo RP, Patti J, Hintz KA, et al. Macrophage inflammatory protein-1alpha (not T helper type 2 cytokines) is associated with severe forms of respiratory syncytial virus bronchiolitis. J Infect Dis. 2001;184(4):393-9.
Garofalo, R. P., Patti, J., Hintz, K. A., Hill, V., Ogra, P. L., & Welliver, R. C. (2001). Macrophage inflammatory protein-1alpha (not T helper type 2 cytokines) is associated with severe forms of respiratory syncytial virus bronchiolitis. The Journal of Infectious Diseases, 184(4), 393-9.
Garofalo RP, et al. Macrophage Inflammatory Protein-1alpha (not T Helper Type 2 Cytokines) Is Associated With Severe Forms of Respiratory Syncytial Virus Bronchiolitis. J Infect Dis. 2001 Aug 15;184(4):393-9. PubMed PMID: 11471095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macrophage inflammatory protein-1alpha (not T helper type 2 cytokines) is associated with severe forms of respiratory syncytial virus bronchiolitis. AU - Garofalo,R P, AU - Patti,J, AU - Hintz,K A, AU - Hill,V, AU - Ogra,P L, AU - Welliver,R C, Y1 - 2001/07/13/ PY - 2000/12/18/received PY - 2001/05/04/revised PY - 2001/7/27/pubmed PY - 2001/9/21/medline PY - 2001/7/27/entrez SP - 393 EP - 9 JF - The Journal of infectious diseases JO - J Infect Dis VL - 184 IS - 4 N2 - It has been suggested that the pathogenesis of respiratory syncytial virus (RSV) infection is related to the development of T helper (Th) type 2 cytokine responses. The presence of Th1 and Th2 cytokines and the chemokines macrophage inflammatory protein (MIP)-1alpha and monocyte chemotactic protein (MCP)-1 were assessed by ELISA in nasopharyngeal secretions of infants with RSV infection. Infants with mild bronchiolitis had increased Th1 cytokines and reduced Th2 cytokines, compared with infants with upper respiratory tract illness alone. Severe bronchiolitis was characterized by a more balanced Th1-Th2 response that did not differ from that of infants with upper respiratory tract illness alone. In contrast, MIP-1alpha was markedly increased in infants with severe bronchiolitis. MIP-1alpha and MCP-1 levels also were inversely related to oxygen saturation (P<.005). Thus, the severity of RSV bronchiolitis appears to be related more to chemokine release than to Th2 cytokine production. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/11471095/Macrophage_inflammatory_protein_1alpha__not_T_helper_type_2_cytokines__is_associated_with_severe_forms_of_respiratory_syncytial_virus_bronchiolitis_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/322788 DB - PRIME DP - Unbound Medicine ER -