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[Serum transferrin receptor in healthy children].
An Esp Pediatr. 2001 Aug; 55(2):113-20.AE

Abstract

BACKGROUND

Serum transferrin receptor (sTfR) is a reliable tool for assessing functional iron status and erythropoietic activity in adults, but little is known about its role in children.

OBJECTIVE

To evaluate sTfR concentrations in healthy children and age and sex-related variations. A further aim was to determine the relationship of these concentrations with other iron parameters and with erythropoietin.

PATIENTS AND METHODS

Blood samples from 155 healthy children aged 1-10 years old were obtained to determine sTfR, iron status indices and erythropoietin. The sTfR/ferritin ratio and the sTfR-ferritin index (sTfR/log ferritin) were calculated. Iron deficiency and increased erythropoiesis were eliminated.

RESULTS

Values of sTfR, the sTfR/ferritin ratio and the sTfR-F index were 1.94 0.41mg/L (95 % CI: 1.14-2.74 mg/L), 83 40.3 (95 % CI: 4-162) and 1.4 0.36 (95 % CI: 0.69-2.1) respectively. No significant sex-related differences were found. Children aged 1-2 years old showed the highest sTfR levels. sTfR was directly related to erythrocyte count (r: 0.17; p < 0,03), hemoglobin level (r: 0.16; p < 0.05) and total iron binding capacity (r: 0.258; p < 0,001). In the multiple linear regression analysis, the best predictors of sTfR concentrations were log erythropoietin (p < 0.016) and total iron binding capacity (p < 0.0001).

CONCLUSIONS

sTfR concentrations are elevated in children due to increased iron requirements for growth. In healthy children sTfR concentrations are related to erythropoietic activity and intracellular iron requirements. The current data are useful as a standard reference for healthy children.

Authors+Show Affiliations

Servicios de Pediatría Hospital Torrecárdenas, Almería. mavazquezl@terra.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

11472662

Citation

Vázquez López, M F., et al. "[Serum Transferrin Receptor in Healthy Children]." Anales Espanoles De Pediatria, vol. 55, no. 2, 2001, pp. 113-20.
Vázquez López MF, Carracedo Morales A, Muñoz Vico J, et al. [Serum transferrin receptor in healthy children]. An Esp Pediatr. 2001;55(2):113-20.
Vázquez López, M. F., Carracedo Morales, A., Muñoz Vico, J., Morcillo Llorens, R., Calvo Bonachera, M. D., López Muñoz, J., & Muñoz Hoyos, A. (2001). [Serum transferrin receptor in healthy children]. Anales Espanoles De Pediatria, 55(2), 113-20.
Vázquez López MF, et al. [Serum Transferrin Receptor in Healthy Children]. An Esp Pediatr. 2001;55(2):113-20. PubMed PMID: 11472662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serum transferrin receptor in healthy children]. AU - Vázquez López,M F, AU - Carracedo Morales,A, AU - Muñoz Vico,J, AU - Morcillo Llorens,R, AU - Calvo Bonachera,M D, AU - López Muñoz,J, AU - Muñoz Hoyos,A, PY - 2001/7/27/pubmed PY - 2001/10/12/medline PY - 2001/7/27/entrez SP - 113 EP - 20 JF - Anales espanoles de pediatria JO - An. Esp. Pediatr. VL - 55 IS - 2 N2 - BACKGROUND: Serum transferrin receptor (sTfR) is a reliable tool for assessing functional iron status and erythropoietic activity in adults, but little is known about its role in children. OBJECTIVE: To evaluate sTfR concentrations in healthy children and age and sex-related variations. A further aim was to determine the relationship of these concentrations with other iron parameters and with erythropoietin. PATIENTS AND METHODS: Blood samples from 155 healthy children aged 1-10 years old were obtained to determine sTfR, iron status indices and erythropoietin. The sTfR/ferritin ratio and the sTfR-ferritin index (sTfR/log ferritin) were calculated. Iron deficiency and increased erythropoiesis were eliminated. RESULTS: Values of sTfR, the sTfR/ferritin ratio and the sTfR-F index were 1.94 0.41mg/L (95 % CI: 1.14-2.74 mg/L), 83 40.3 (95 % CI: 4-162) and 1.4 0.36 (95 % CI: 0.69-2.1) respectively. No significant sex-related differences were found. Children aged 1-2 years old showed the highest sTfR levels. sTfR was directly related to erythrocyte count (r: 0.17; p < 0,03), hemoglobin level (r: 0.16; p < 0.05) and total iron binding capacity (r: 0.258; p < 0,001). In the multiple linear regression analysis, the best predictors of sTfR concentrations were log erythropoietin (p < 0.016) and total iron binding capacity (p < 0.0001). CONCLUSIONS: sTfR concentrations are elevated in children due to increased iron requirements for growth. In healthy children sTfR concentrations are related to erythropoietic activity and intracellular iron requirements. The current data are useful as a standard reference for healthy children. SN - 0302-4342 UR - https://www.unboundmedicine.com/medline/citation/11472662/[Serum_transferrin_receptor_in_healthy_children]_ DB - PRIME DP - Unbound Medicine ER -