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Relationships between alcoholic beverages and cardiovascular risk factor levels in middle-aged men, the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction Study.
Atherosclerosis 2001; 157(2):431-40A

Abstract

The relationships between alcoholic beverages and cardiovascular risk factors were assessed in 6730 men living in France or Northern Ireland. In France, all alcoholic beverages were significantly correlated with body mass index (BMI), systolic (SBP) and diastolic blood pressure (DBP), high density lipoprotein (HDL) parameters, PAI-1 and Factor VII, whereas only wine was negatively related with fibrinogen levels. After adjusting for center, age, BMI, educational level, smoking and marital status, wine had a lesser effect on blood pressure, triglyceride, apo B and LpE:B levels than beer. Wine was associated with lower fibrinogen levels and beer with higher PAI-1 activity levels independent of the amount of alcohol consumed. In Northern Ireland, wine was negatively correlated with BMI, triglycerides, LpE:B and fibrinogen, whereas beer was positively correlated with SBP and DBP, triglycerides, HDL, apoprotein A-I and fibrinogen. Multivariate analysis showed wine to be positively associated with HDL parameters, and negatively with fibrinogen levels. Wine was also associated with higher LpA-I levels and lower fibrinogen levels independent of the amount of alcohol consumed. We conclude that alcohol consumption is related to lipid, lipoprotein and haemostatic variables, but the magnitude of the relationships depends on the type of alcoholic beverage. Also, some effects might be related to non-alcoholic components.

Authors+Show Affiliations

INSERM U518, Faculté de Médecine Purpan, Département d'Epidémiologie, 1er ét., 37, Allées Jules Guesde, 31073 Toulouse Cedex, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11472744

Citation

Marques-Vidal, P, et al. "Relationships Between Alcoholic Beverages and Cardiovascular Risk Factor Levels in Middle-aged Men, the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction Study." Atherosclerosis, vol. 157, no. 2, 2001, pp. 431-40.
Marques-Vidal P, Montaye M, Haas B, et al. Relationships between alcoholic beverages and cardiovascular risk factor levels in middle-aged men, the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction Study. Atherosclerosis. 2001;157(2):431-40.
Marques-Vidal, P., Montaye, M., Haas, B., Bingham, A., Evans, A., Juhan-Vague, I., ... Ducimetière, P. (2001). Relationships between alcoholic beverages and cardiovascular risk factor levels in middle-aged men, the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction Study. Atherosclerosis, 157(2), pp. 431-40.
Marques-Vidal P, et al. Relationships Between Alcoholic Beverages and Cardiovascular Risk Factor Levels in Middle-aged Men, the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction Study. Atherosclerosis. 2001;157(2):431-40. PubMed PMID: 11472744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between alcoholic beverages and cardiovascular risk factor levels in middle-aged men, the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction Study. AU - Marques-Vidal,P, AU - Montaye,M, AU - Haas,B, AU - Bingham,A, AU - Evans,A, AU - Juhan-Vague,I, AU - Ferrières,J, AU - Luc,G, AU - Amouyel,P, AU - Arveiler,D, AU - Yarnell,J, AU - Ruidavets,J B, AU - Scarabin,P Y, AU - Ducimetière,P, PY - 2001/7/27/pubmed PY - 2001/10/26/medline PY - 2001/7/27/entrez SP - 431 EP - 40 JF - Atherosclerosis JO - Atherosclerosis VL - 157 IS - 2 N2 - The relationships between alcoholic beverages and cardiovascular risk factors were assessed in 6730 men living in France or Northern Ireland. In France, all alcoholic beverages were significantly correlated with body mass index (BMI), systolic (SBP) and diastolic blood pressure (DBP), high density lipoprotein (HDL) parameters, PAI-1 and Factor VII, whereas only wine was negatively related with fibrinogen levels. After adjusting for center, age, BMI, educational level, smoking and marital status, wine had a lesser effect on blood pressure, triglyceride, apo B and LpE:B levels than beer. Wine was associated with lower fibrinogen levels and beer with higher PAI-1 activity levels independent of the amount of alcohol consumed. In Northern Ireland, wine was negatively correlated with BMI, triglycerides, LpE:B and fibrinogen, whereas beer was positively correlated with SBP and DBP, triglycerides, HDL, apoprotein A-I and fibrinogen. Multivariate analysis showed wine to be positively associated with HDL parameters, and negatively with fibrinogen levels. Wine was also associated with higher LpA-I levels and lower fibrinogen levels independent of the amount of alcohol consumed. We conclude that alcohol consumption is related to lipid, lipoprotein and haemostatic variables, but the magnitude of the relationships depends on the type of alcoholic beverage. Also, some effects might be related to non-alcoholic components. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/11472744/Relationships_between_alcoholic_beverages_and_cardiovascular_risk_factor_levels_in_middle_aged_men_the_PRIME_Study__Prospective_Epidemiological_Study_of_Myocardial_Infarction_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(00)00734-6 DB - PRIME DP - Unbound Medicine ER -