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Botulinum toxin type A (BOTOX) for treatment of migraine.
Semin Cutan Med Surg 2001; 20(2):93-100SC

Abstract

An open-label study and 2 double-blind, placebo-controlled studies have provided supporting evidence of botulinum toxin type A (BTX-A) as an effective, well-tolerated treatment for migraine. Observed durations of benefit were consistent with known properties of BTX-A. Findings suggest that response may vary by features of preinjection headaches, such as migraine frequency. The precise mechanism by which BTX-A provides pain relief is hypothesized to be related not only to acetylcholine inhibition but also to a blocking action on the parasympathetic nervous system. Additional studies that control factors likely to be related to response may lead to better understanding of the BTX-A effect on migraine and an optimal treatment protocol.

Authors+Show Affiliations

Department of Head and Neck Surgery, University of California, Los Angeles, USA. wjb@doctorbinder.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11474749

Citation

Binder, W J., et al. "Botulinum Toxin Type a (BOTOX) for Treatment of Migraine." Seminars in Cutaneous Medicine and Surgery, vol. 20, no. 2, 2001, pp. 93-100.
Binder WJ, Brin MF, Blitzer A, et al. Botulinum toxin type A (BOTOX) for treatment of migraine. Semin Cutan Med Surg. 2001;20(2):93-100.
Binder, W. J., Brin, M. F., Blitzer, A., & Pogoda, J. M. (2001). Botulinum toxin type A (BOTOX) for treatment of migraine. Seminars in Cutaneous Medicine and Surgery, 20(2), pp. 93-100.
Binder WJ, et al. Botulinum Toxin Type a (BOTOX) for Treatment of Migraine. Semin Cutan Med Surg. 2001;20(2):93-100. PubMed PMID: 11474749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Botulinum toxin type A (BOTOX) for treatment of migraine. AU - Binder,W J, AU - Brin,M F, AU - Blitzer,A, AU - Pogoda,J M, PY - 2001/7/28/pubmed PY - 2002/1/5/medline PY - 2001/7/28/entrez SP - 93 EP - 100 JF - Seminars in cutaneous medicine and surgery JO - Semin Cutan Med Surg VL - 20 IS - 2 N2 - An open-label study and 2 double-blind, placebo-controlled studies have provided supporting evidence of botulinum toxin type A (BTX-A) as an effective, well-tolerated treatment for migraine. Observed durations of benefit were consistent with known properties of BTX-A. Findings suggest that response may vary by features of preinjection headaches, such as migraine frequency. The precise mechanism by which BTX-A provides pain relief is hypothesized to be related not only to acetylcholine inhibition but also to a blocking action on the parasympathetic nervous system. Additional studies that control factors likely to be related to response may lead to better understanding of the BTX-A effect on migraine and an optimal treatment protocol. SN - 1085-5629 UR - https://www.unboundmedicine.com/medline/citation/11474749/Botulinum_toxin_type_A__BOTOX__for_treatment_of_migraine_ L2 - http://scmsjournal.com/article/buy_now/?id=626 DB - PRIME DP - Unbound Medicine ER -