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Clinical validity of a self-test fructosamine in outpatient diabetic management.
Diabetes Technol Ther. 1999 Winter; 1(4):435-41.DT

Abstract

BACKGROUND

Measurement of glycated hemoglobin and hemoglobin A1c (HbA1c) is now well established as the best means of measuring overall glucose control in managing diabetes. Other glycated serum protein assays reflecting recent glycemic control, e.g., glycated albumin and glycated protein (fructosamine), have also been validated in clinical studies. Regardless of the method, the expense and inconvenience of laboratory testing of blood samples may contribute to the well-documented underutilization of clinical glycated protein assessment. Accordingly, a rapid, inexpensive fingerstick test of fructosamine has been developed. This study cross-sectionally and prospectively assesses the clinical validity of fingerstick fructosamine versus laboratory determination.

METHODS

Fifty-one subjects (18 control, 33 with diabetes) participated in a cross-sectional study and 20 subjects with type 2 diabetes participated in a prospective, 6-week study with clinical intervention consisting of glipizide gits or metformin in mono- and combination therapy. Subjects had weekly laboratory determination of serum fructosamine, glycated hemoglobin, and fasting glucose; fingerstick fructosamine was obtained at each clinic visit.

RESULTS

Fingerstick fructosamine was shown to correlate highly to laboratory fructosamine (r = 0.80, p < 0.001) and glycated hemoglobin (r = 0.81, p < 0.001). In the clinical intervention study subjects, significant decreases in fasting glucose (p < 0.001), laboratory fructosamine (p < 0.001), and fingerstick fructosamine (p < 0.001) were noted compared to baseline. The subject's self-test fingerstick fructosamine mirrored laboratory testing of fructosamine in detection of changes in clinical glucose control.

CONCLUSIONS

This study demonstrates that fingerstick fructosamine correlates well to laboratory assessment of fructosamine and glycated hemoglobin. The patient self-test fructosamine provides the same clinical information as laboratory assessment.

Links

Publisher Full Text

Authors+Show Affiliations

Cefalu WT
Department of Medicine, College of Medicine, University of Vermont, Burlington, Vermont, USA. wcefalu@zoo.uvm.edu
Wang ZQ
No affiliation info available
Redmon E
No affiliation info available
Bell-Farrow AD
No affiliation info available
McBride D
No affiliation info available
King T
No affiliation info available

MeSH

AdultBiomarkersBlood Specimen CollectionCross-Sectional StudiesDiabetes MellitusDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FructosamineGlycated Hemoglobin AHumansMiddle AgedMonitoring, AmbulatoryMonitoring, PhysiologicReference ValuesRegression AnalysisSelf CareTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11474829

Citation

Cefalu, W T., et al. "Clinical Validity of a Self-test Fructosamine in Outpatient Diabetic Management." Diabetes Technology & Therapeutics, vol. 1, no. 4, 1999, pp. 435-41.
Cefalu WT, Wang ZQ, Redmon E, et al. Clinical validity of a self-test fructosamine in outpatient diabetic management. Diabetes Technol Ther. 1999;1(4):435-41.
Cefalu, W. T., Wang, Z. Q., Redmon, E., Bell-Farrow, A. D., McBride, D., & King, T. (1999). Clinical validity of a self-test fructosamine in outpatient diabetic management. Diabetes Technology & Therapeutics, 1(4), 435-41.
Cefalu WT, et al. Clinical Validity of a Self-test Fructosamine in Outpatient Diabetic Management. Diabetes Technol Ther. 1999;1(4):435-41. PubMed PMID: 11474829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical validity of a self-test fructosamine in outpatient diabetic management. AU - Cefalu,W T, AU - Wang,Z Q, AU - Redmon,E, AU - Bell-Farrow,A D, AU - McBride,D, AU - King,T, PY - 2001/7/28/pubmed PY - 2001/8/24/medline PY - 2001/7/28/entrez SP - 435 EP - 41 JF - Diabetes technology & therapeutics JO - Diabetes Technol Ther VL - 1 IS - 4 N2 - BACKGROUND: Measurement of glycated hemoglobin and hemoglobin A1c (HbA1c) is now well established as the best means of measuring overall glucose control in managing diabetes. Other glycated serum protein assays reflecting recent glycemic control, e.g., glycated albumin and glycated protein (fructosamine), have also been validated in clinical studies. Regardless of the method, the expense and inconvenience of laboratory testing of blood samples may contribute to the well-documented underutilization of clinical glycated protein assessment. Accordingly, a rapid, inexpensive fingerstick test of fructosamine has been developed. This study cross-sectionally and prospectively assesses the clinical validity of fingerstick fructosamine versus laboratory determination. METHODS: Fifty-one subjects (18 control, 33 with diabetes) participated in a cross-sectional study and 20 subjects with type 2 diabetes participated in a prospective, 6-week study with clinical intervention consisting of glipizide gits or metformin in mono- and combination therapy. Subjects had weekly laboratory determination of serum fructosamine, glycated hemoglobin, and fasting glucose; fingerstick fructosamine was obtained at each clinic visit. RESULTS: Fingerstick fructosamine was shown to correlate highly to laboratory fructosamine (r = 0.80, p < 0.001) and glycated hemoglobin (r = 0.81, p < 0.001). In the clinical intervention study subjects, significant decreases in fasting glucose (p < 0.001), laboratory fructosamine (p < 0.001), and fingerstick fructosamine (p < 0.001) were noted compared to baseline. The subject's self-test fingerstick fructosamine mirrored laboratory testing of fructosamine in detection of changes in clinical glucose control. CONCLUSIONS: This study demonstrates that fingerstick fructosamine correlates well to laboratory assessment of fructosamine and glycated hemoglobin. The patient self-test fructosamine provides the same clinical information as laboratory assessment. SN - 1520-9156 UR - https://www.unboundmedicine.com/medline/citation/11474829/Clinical_validity_of_a_self_test_fructosamine_in_outpatient_diabetic_management_ L2 - https://www.liebertpub.com/doi/10.1089/152091599316964?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -