TY - JOUR T1 - Determination of reference values for a novel ketoamine-specific fructosamine assay for assessment of diabetic glycemic control. AU - O'Brien,J E, AU - Brookes,M, PY - 2001/7/28/pubmed PY - 2001/8/24/medline PY - 2001/7/28/entrez SP - 447 EP - 55 JF - Diabetes technology & therapeutics JO - Diabetes Technol Ther VL - 1 IS - 4 N2 - BACKGROUND: Intensive monitoring to improve glycemic control is essential for effective management of diabetes and reduction of long-term morbidity and pathology. Measurement of glycated serum proteins (fructosamine) allows more frequent assessment (monthly) of glycemic control than the 2- to 3-month window of the traditional glycated hemoglobin (HbA1c) assay. In response to concerns about assays designed to measure glycated serum proteins based on the nitroblue tetrazolium (NBT) methodology, a novel assay to measure glycated serum proteins has been developed based on the specific oxidation of the ketoamine bonds within the glycated proteins. METHODS: Reference range values for this new, enzymatic glycated-serum-protein assay (GlyPro; Genzyme Corporation, Cambridge, MA) are reported. RESULTS: The GlyPro reference range is lower and shows close correlation with ranges reported for the NBT assay. The 95% overall reference range was 122 to 236 mumol/L. CONCLUSIONS: GlyPro is a reliable, accurate assay and correlates well with the NBT assay for the measurement of glycated serum proteins. The assay may be useful in the short-term assessment of diabetes control, a necessary complement to long-term control as assessed by hemoglobin A1c (HbA1c) assays. SN - 1520-9156 UR - https://www.unboundmedicine.com/medline/citation/11474831/Determination_of_reference_values_for_a_novel_ketoamine_specific_fructosamine_assay_for_assessment_of_diabetic_glycemic_control_ L2 - https://www.liebertpub.com/doi/10.1089/152091599316982?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -