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Age-dependent relationship between bronchial hyperresponsiveness to methacholine and total serum IgE level in asthmatic children.

Abstract

BACKGROUND

A relationship between nonspecific bronchial hyperresponsiveness and allergic airway inflammation has been reported in children and in adults with asthma, but the relationship in infants with asthma is still unclear.

OBJECTIVE

To evaluate the relationship between bronchial hyperresponsiveness and total serum IgE level throughout childhood. Bronchial reactivity to methacholine from the age of 1 to 16 years was studied by methacholine inhalation challenge using transcutaneous oxygen pressure (tcPO2) monitoring.

METHODS

Two hundred one asthmatic children (boys:girls = 132:69; 7.3+/-4.0 years of age, mean +/- SD) were enrolled in this study. The tcPO2 was measured using a tcPO2 monitor. Serial doses of methacholine were doubled until a 10% decrease in tcPO2 from the baseline was reached. The cumulative dose of methacholine at the inflection point of tcPO2 was considered to represent the bronchial reactivity to methacholine.

RESULTS

There was no relationship between the cumulative dose of methacholine at the inflection point of tcPO2 and total serum IgE level in the group of children aged 1 to 4 years (P = 0.212), but significant correlations were found in the groups aged 5 to 10 years and 11 to 16 years (P = 0.044 and P = 0.014, respectively).

CONCLUSIONS

We conclude that there is an age-dependent relationship between bronchial reactivity to methacholine and the total serum IgE level and that inhaled allergens, which were more common allergens in older children, may have some effects on the degree of bronchial reactivity to methacholine in children with asthma.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics, Gunma University School of Medicine, Maebashi, Japan.

    , , , ,

    Source

    MeSH

    Administration, Inhalation
    Adolescent
    Age Factors
    Allergens
    Animals
    Asthma
    Bronchial Hyperreactivity
    Child
    Child, Preschool
    Female
    Food Hypersensitivity
    Humans
    Immunoglobulin E
    Infant
    Male
    Methacholine Chloride
    Milk
    Ovalbumin
    Oxygen
    Partial Pressure
    Radioallergosorbent Test

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    11476459

    Citation

    Kono, M, et al. "Age-dependent Relationship Between Bronchial Hyperresponsiveness to Methacholine and Total Serum IgE Level in Asthmatic Children." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 87, no. 1, 2001, pp. 33-8.
    Kono M, Mochizuki H, Arakawa H, et al. Age-dependent relationship between bronchial hyperresponsiveness to methacholine and total serum IgE level in asthmatic children. Ann Allergy Asthma Immunol. 2001;87(1):33-8.
    Kono, M., Mochizuki, H., Arakawa, H., Kato, M., Tokuyama, K., & Morikawa, A. (2001). Age-dependent relationship between bronchial hyperresponsiveness to methacholine and total serum IgE level in asthmatic children. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 87(1), pp. 33-8.
    Kono M, et al. Age-dependent Relationship Between Bronchial Hyperresponsiveness to Methacholine and Total Serum IgE Level in Asthmatic Children. Ann Allergy Asthma Immunol. 2001;87(1):33-8. PubMed PMID: 11476459.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Age-dependent relationship between bronchial hyperresponsiveness to methacholine and total serum IgE level in asthmatic children. AU - Kono,M, AU - Mochizuki,H, AU - Arakawa,H, AU - Kato,M, AU - Tokuyama,K, AU - Morikawa,A, PY - 2001/7/31/pubmed PY - 2001/10/26/medline PY - 2001/7/31/entrez SP - 33 EP - 8 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 87 IS - 1 N2 - BACKGROUND: A relationship between nonspecific bronchial hyperresponsiveness and allergic airway inflammation has been reported in children and in adults with asthma, but the relationship in infants with asthma is still unclear. OBJECTIVE: To evaluate the relationship between bronchial hyperresponsiveness and total serum IgE level throughout childhood. Bronchial reactivity to methacholine from the age of 1 to 16 years was studied by methacholine inhalation challenge using transcutaneous oxygen pressure (tcPO2) monitoring. METHODS: Two hundred one asthmatic children (boys:girls = 132:69; 7.3+/-4.0 years of age, mean +/- SD) were enrolled in this study. The tcPO2 was measured using a tcPO2 monitor. Serial doses of methacholine were doubled until a 10% decrease in tcPO2 from the baseline was reached. The cumulative dose of methacholine at the inflection point of tcPO2 was considered to represent the bronchial reactivity to methacholine. RESULTS: There was no relationship between the cumulative dose of methacholine at the inflection point of tcPO2 and total serum IgE level in the group of children aged 1 to 4 years (P = 0.212), but significant correlations were found in the groups aged 5 to 10 years and 11 to 16 years (P = 0.044 and P = 0.014, respectively). CONCLUSIONS: We conclude that there is an age-dependent relationship between bronchial reactivity to methacholine and the total serum IgE level and that inhaled allergens, which were more common allergens in older children, may have some effects on the degree of bronchial reactivity to methacholine in children with asthma. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/11476459/Age_dependent_relationship_between_bronchial_hyperresponsiveness_to_methacholine_and_total_serum_IgE_level_in_asthmatic_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)62319-8 DB - PRIME DP - Unbound Medicine ER -