A case of allergy to beer showing cross-reactivity between lipid transfer proteins.Ann Allergy Asthma Immunol 2001; 87(1):65-7AA
Abstract
BACKGROUND
Lipid transfer proteins (LTPs) are highly conserved proteins present in a broad spectrum of fruits and vegetables that might represent a novel plant panallergen.
OBJECTIVE
To demonstrate that LTP is an important allergen in beer and that beer LTP cross-reacts with LTP from botanically unrelated plant-derived foods.
METHODS
Serum from a patient with clinical allergy to both beer and Rosaceae was studied for IgE reactivity to LTP to several vegetable foods by RAST, ELISA, immunoblot, and inhibition studies.
RESULTS
Patient's serum showed a strong IgE reactivity to LTP purified from peach peel, carrot, and broccoli, and to a 10 kD protein in both apple and peach immunoblots, whereas no reactivity to birch cross-reactive allergens such as Bet v 1, profilin, or carbohydrates was found. In inhibition studies, preabsorption of serum with apple, walnut, hazelnut, peanut, corn, and rice caused a fall of 97%, 20%, 66%, 91%, 94%, and 93%, respectively, of its reactivity to peach LTP. Beer RAST fell from 1.8 IU/mL to <0.1 IU/mL when a patient's serum was preabsorbed with recombinant carrot LTP.
CONCLUSIONS
LTP is a relevant allergen in beer. Beer LTP may cross-react with LTP from several other plant-derived foods.
Pub Type(s)
Case Reports
Journal Article
Language
eng
PubMed ID
11476466
Citation
Asero, R, et al. "A Case of Allergy to Beer Showing Cross-reactivity Between Lipid Transfer Proteins." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 87, no. 1, 2001, pp. 65-7.
Asero R, Mistrello G, Roncarolo D, et al. A case of allergy to beer showing cross-reactivity between lipid transfer proteins. Ann Allergy Asthma Immunol. 2001;87(1):65-7.
Asero, R., Mistrello, G., Roncarolo, D., Amato, S., & van Ree, R. (2001). A case of allergy to beer showing cross-reactivity between lipid transfer proteins. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 87(1), pp. 65-7.
Asero R, et al. A Case of Allergy to Beer Showing Cross-reactivity Between Lipid Transfer Proteins. Ann Allergy Asthma Immunol. 2001;87(1):65-7. PubMed PMID: 11476466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - A case of allergy to beer showing cross-reactivity between lipid transfer proteins.
AU - Asero,R,
AU - Mistrello,G,
AU - Roncarolo,D,
AU - Amato,S,
AU - van Ree,R,
PY - 2001/7/31/pubmed
PY - 2001/10/26/medline
PY - 2001/7/31/entrez
SP - 65
EP - 7
JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
JO - Ann. Allergy Asthma Immunol.
VL - 87
IS - 1
N2 - BACKGROUND: Lipid transfer proteins (LTPs) are highly conserved proteins present in a broad spectrum of fruits and vegetables that might represent a novel plant panallergen. OBJECTIVE: To demonstrate that LTP is an important allergen in beer and that beer LTP cross-reacts with LTP from botanically unrelated plant-derived foods. METHODS: Serum from a patient with clinical allergy to both beer and Rosaceae was studied for IgE reactivity to LTP to several vegetable foods by RAST, ELISA, immunoblot, and inhibition studies. RESULTS: Patient's serum showed a strong IgE reactivity to LTP purified from peach peel, carrot, and broccoli, and to a 10 kD protein in both apple and peach immunoblots, whereas no reactivity to birch cross-reactive allergens such as Bet v 1, profilin, or carbohydrates was found. In inhibition studies, preabsorption of serum with apple, walnut, hazelnut, peanut, corn, and rice caused a fall of 97%, 20%, 66%, 91%, 94%, and 93%, respectively, of its reactivity to peach LTP. Beer RAST fell from 1.8 IU/mL to <0.1 IU/mL when a patient's serum was preabsorbed with recombinant carrot LTP. CONCLUSIONS: LTP is a relevant allergen in beer. Beer LTP may cross-react with LTP from several other plant-derived foods.
SN - 1081-1206
UR - https://www.unboundmedicine.com/medline/citation/11476466/A_case_of_allergy_to_beer_showing_cross_reactivity_between_lipid_transfer_proteins_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)62325-3
DB - PRIME
DP - Unbound Medicine
ER -
