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A case of allergy to beer showing cross-reactivity between lipid transfer proteins.
Ann Allergy Asthma Immunol 2001; 87(1):65-7AA

Abstract

BACKGROUND

Lipid transfer proteins (LTPs) are highly conserved proteins present in a broad spectrum of fruits and vegetables that might represent a novel plant panallergen.

OBJECTIVE

To demonstrate that LTP is an important allergen in beer and that beer LTP cross-reacts with LTP from botanically unrelated plant-derived foods.

METHODS

Serum from a patient with clinical allergy to both beer and Rosaceae was studied for IgE reactivity to LTP to several vegetable foods by RAST, ELISA, immunoblot, and inhibition studies.

RESULTS

Patient's serum showed a strong IgE reactivity to LTP purified from peach peel, carrot, and broccoli, and to a 10 kD protein in both apple and peach immunoblots, whereas no reactivity to birch cross-reactive allergens such as Bet v 1, profilin, or carbohydrates was found. In inhibition studies, preabsorption of serum with apple, walnut, hazelnut, peanut, corn, and rice caused a fall of 97%, 20%, 66%, 91%, 94%, and 93%, respectively, of its reactivity to peach LTP. Beer RAST fell from 1.8 IU/mL to <0.1 IU/mL when a patient's serum was preabsorbed with recombinant carrot LTP.

CONCLUSIONS

LTP is a relevant allergen in beer. Beer LTP may cross-react with LTP from several other plant-derived foods.

Authors+Show Affiliations

Ambulatorio di Allergologia, Ospedale Caduti Bollatesi, Bollate, MI, Italy. r.asero@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11476466

Citation

Asero, R, et al. "A Case of Allergy to Beer Showing Cross-reactivity Between Lipid Transfer Proteins." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 87, no. 1, 2001, pp. 65-7.
Asero R, Mistrello G, Roncarolo D, et al. A case of allergy to beer showing cross-reactivity between lipid transfer proteins. Ann Allergy Asthma Immunol. 2001;87(1):65-7.
Asero, R., Mistrello, G., Roncarolo, D., Amato, S., & van Ree, R. (2001). A case of allergy to beer showing cross-reactivity between lipid transfer proteins. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 87(1), pp. 65-7.
Asero R, et al. A Case of Allergy to Beer Showing Cross-reactivity Between Lipid Transfer Proteins. Ann Allergy Asthma Immunol. 2001;87(1):65-7. PubMed PMID: 11476466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of allergy to beer showing cross-reactivity between lipid transfer proteins. AU - Asero,R, AU - Mistrello,G, AU - Roncarolo,D, AU - Amato,S, AU - van Ree,R, PY - 2001/7/31/pubmed PY - 2001/10/26/medline PY - 2001/7/31/entrez SP - 65 EP - 7 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 87 IS - 1 N2 - BACKGROUND: Lipid transfer proteins (LTPs) are highly conserved proteins present in a broad spectrum of fruits and vegetables that might represent a novel plant panallergen. OBJECTIVE: To demonstrate that LTP is an important allergen in beer and that beer LTP cross-reacts with LTP from botanically unrelated plant-derived foods. METHODS: Serum from a patient with clinical allergy to both beer and Rosaceae was studied for IgE reactivity to LTP to several vegetable foods by RAST, ELISA, immunoblot, and inhibition studies. RESULTS: Patient's serum showed a strong IgE reactivity to LTP purified from peach peel, carrot, and broccoli, and to a 10 kD protein in both apple and peach immunoblots, whereas no reactivity to birch cross-reactive allergens such as Bet v 1, profilin, or carbohydrates was found. In inhibition studies, preabsorption of serum with apple, walnut, hazelnut, peanut, corn, and rice caused a fall of 97%, 20%, 66%, 91%, 94%, and 93%, respectively, of its reactivity to peach LTP. Beer RAST fell from 1.8 IU/mL to <0.1 IU/mL when a patient's serum was preabsorbed with recombinant carrot LTP. CONCLUSIONS: LTP is a relevant allergen in beer. Beer LTP may cross-react with LTP from several other plant-derived foods. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/11476466/A_case_of_allergy_to_beer_showing_cross_reactivity_between_lipid_transfer_proteins_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)62325-3 DB - PRIME DP - Unbound Medicine ER -