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[Bioavailability of iron in oral iron preparations. Principles of duration and dosage (author's transl)].
MMW Munch Med Wochenschr. 1979 Aug 31; 121(35):1104-8.MM

Abstract

Using 59Fe labeled iron preparations, both the exactly and quantitatively determined absorbability by whole body retention measurement of the absorbed 59Fe and the calculated relative bioavailability from the postabsorption rise in serum iron concentration have coincidently shown that only about half as much Fe (II) is absorbed from oral iron preparations with delayed liberation of iron in the small intestine than from an Fe (II) preparation liberating Fe (II) more rapidly in the stomach. From preparations with trivalent iron only 1/7 to 1/20 of the amount of iron is absorbed which can be absorbed from an Fe (II) preparation with a more rapid rate of Fe liberation. The optimal oral iron therapy is therefore with aqueous solutions of Fe (II) or Fe (II) preparations which disintegrate immediately in the stomach.

Authors

Heinrich HC
No affiliation info available
Gabbe EE
No affiliation info available

MeSH

Anemia, HypochromicBiological AvailabilityDelayed-Action PreparationsDose-Response Relationship, DrugDrug Administration ScheduleHumansIntestinal AbsorptionIron

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

114773

Citation

Heinrich, H C., and E E. Gabbe. "[Bioavailability of Iron in Oral Iron Preparations. Principles of Duration and Dosage (author's Transl)]." MMW, Munchener Medizinische Wochenschrift, vol. 121, no. 35, 1979, pp. 1104-8.
Heinrich HC, Gabbe EE. [Bioavailability of iron in oral iron preparations. Principles of duration and dosage (author's transl)]. MMW Munch Med Wochenschr. 1979;121(35):1104-8.
Heinrich, H. C., & Gabbe, E. E. (1979). [Bioavailability of iron in oral iron preparations. Principles of duration and dosage (author's transl)]. MMW, Munchener Medizinische Wochenschrift, 121(35), 1104-8.
Heinrich HC, Gabbe EE. [Bioavailability of Iron in Oral Iron Preparations. Principles of Duration and Dosage (author's Transl)]. MMW Munch Med Wochenschr. 1979 Aug 31;121(35):1104-8. PubMed PMID: 114773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bioavailability of iron in oral iron preparations. Principles of duration and dosage (author's transl)]. AU - Heinrich,H C, AU - Gabbe,E E, PY - 1979/8/31/pubmed PY - 1979/8/31/medline PY - 1979/8/31/entrez SP - 1104 EP - 8 JF - MMW, Munchener medizinische Wochenschrift JO - MMW Munch Med Wochenschr VL - 121 IS - 35 N2 - Using 59Fe labeled iron preparations, both the exactly and quantitatively determined absorbability by whole body retention measurement of the absorbed 59Fe and the calculated relative bioavailability from the postabsorption rise in serum iron concentration have coincidently shown that only about half as much Fe (II) is absorbed from oral iron preparations with delayed liberation of iron in the small intestine than from an Fe (II) preparation liberating Fe (II) more rapidly in the stomach. From preparations with trivalent iron only 1/7 to 1/20 of the amount of iron is absorbed which can be absorbed from an Fe (II) preparation with a more rapid rate of Fe liberation. The optimal oral iron therapy is therefore with aqueous solutions of Fe (II) or Fe (II) preparations which disintegrate immediately in the stomach. SN - 0341-3098 UR - https://www.unboundmedicine.com/medline/citation/114773/[Bioavailability_of_iron_in_oral_iron_preparations__Principles_of_duration_and_dosage__author's_transl_]_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -