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Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years.
Eur J Clin Nutr 2001; 55(8):663-72EJ

Abstract

OBJECTIVE

To determine (1) lean and fat body compartments, reflected by fat-free mass (FFM), appendicular skeletal muscle mass (ASMM), body cell mass (BCM), total body potassium (TBK), fat mass and percentage fat mass, and their differences between age groups in healthy, physically active subjects from 18 to 94 y of age; and (2) if the rate of decrease in any one of the parameters by age might be accelerated compared to others.

METHODS

A total of 433 healthy ambulatory Caucasians (253 men and 180 women) aged 18--94 y were measured by dual-energy X-ray absorptiometry (DXA) and whole body scintillation counter (TBK counter) using a large sodium iodide crystal (203 mm diameter).

RESULTS

The ASMM change (-16.4 and -12.3% in men and women, respectively) in >75 y-old compared to 18 to 34-y-old subjects was greater than the FFM change (-11.8 and -9.7% in men and women, respectively) and this suggests that skeletal muscle mass decrease in older subjects was proportionally greater than non-skeletal muscle mass. BCM (-25.1 and -23.2% in men and women, respectively) and TBK differences were greater than the differences in FFM or ASMM suggesting altered composition of FFM in older subjects. Women had lower peak FFM, ASMM, BCM and TBK than men.

CONCLUSIONS

The decline in FFM, ASMM, BCM and TBK is accelerated in men and women after 60 y of age and FFM, ASMM, BCM and TBK are significantly lower than in younger subjects. Fat mass continued to increase until around 75 y.

Authors+Show Affiliations

Clinical Nutrition, Geneva University Hospital, Geneva, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11477465

Citation

Kyle, U G., et al. "Age-related Differences in Fat-free Mass, Skeletal Muscle, Body Cell Mass and Fat Mass Between 18 and 94 Years." European Journal of Clinical Nutrition, vol. 55, no. 8, 2001, pp. 663-72.
Kyle UG, Genton L, Hans D, et al. Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years. Eur J Clin Nutr. 2001;55(8):663-72.
Kyle, U. G., Genton, L., Hans, D., Karsegard, L., Slosman, D. O., & Pichard, C. (2001). Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years. European Journal of Clinical Nutrition, 55(8), pp. 663-72.
Kyle UG, et al. Age-related Differences in Fat-free Mass, Skeletal Muscle, Body Cell Mass and Fat Mass Between 18 and 94 Years. Eur J Clin Nutr. 2001;55(8):663-72. PubMed PMID: 11477465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years. AU - Kyle,U G, AU - Genton,L, AU - Hans,D, AU - Karsegard,L, AU - Slosman,D O, AU - Pichard,C, PY - 2000/10/10/received PY - 2001/01/17/revised PY - 2001/01/18/accepted PY - 2001/7/31/pubmed PY - 2001/9/8/medline PY - 2001/7/31/entrez SP - 663 EP - 72 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 55 IS - 8 N2 - OBJECTIVE: To determine (1) lean and fat body compartments, reflected by fat-free mass (FFM), appendicular skeletal muscle mass (ASMM), body cell mass (BCM), total body potassium (TBK), fat mass and percentage fat mass, and their differences between age groups in healthy, physically active subjects from 18 to 94 y of age; and (2) if the rate of decrease in any one of the parameters by age might be accelerated compared to others. METHODS: A total of 433 healthy ambulatory Caucasians (253 men and 180 women) aged 18--94 y were measured by dual-energy X-ray absorptiometry (DXA) and whole body scintillation counter (TBK counter) using a large sodium iodide crystal (203 mm diameter). RESULTS: The ASMM change (-16.4 and -12.3% in men and women, respectively) in >75 y-old compared to 18 to 34-y-old subjects was greater than the FFM change (-11.8 and -9.7% in men and women, respectively) and this suggests that skeletal muscle mass decrease in older subjects was proportionally greater than non-skeletal muscle mass. BCM (-25.1 and -23.2% in men and women, respectively) and TBK differences were greater than the differences in FFM or ASMM suggesting altered composition of FFM in older subjects. Women had lower peak FFM, ASMM, BCM and TBK than men. CONCLUSIONS: The decline in FFM, ASMM, BCM and TBK is accelerated in men and women after 60 y of age and FFM, ASMM, BCM and TBK are significantly lower than in younger subjects. Fat mass continued to increase until around 75 y. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/11477465/Age_related_differences_in_fat_free_mass_skeletal_muscle_body_cell_mass_and_fat_mass_between_18_and_94_years_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601198 DB - PRIME DP - Unbound Medicine ER -