[Expression of apoptosis regulatory protein bcl-2 and bax in endometrium of polycystic ovary syndrome].Zhonghua Fu Chan Ke Za Zhi. 1999 Nov; 34(11):652-4.ZF
To study the expression and implication of apoptosis regulatory protein bcl-2 and bax in endometrium of polycystic ovary syndrome (PCOS).
The apoptosis regulatory protein expression of bcl-2 and bax protein in endometrium were investigated by immunohistochemical method in 18 PCOS and 27 normal subjects proliferative phase 10 and secretory phase 17.
Bcl-2 expression was higher in PCOS than that both in control proliferative phase (P < 0.05) and secretory phase (P < 0.001). Bax expression was not significantly different between PCOS and controls (P > 0.05).
The higher bcl-2 protein expression inhibits the endometrium apoptosis and plays an important role in the abnormal proliferative changes of endometrium in PCOS.