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[Expression of apoptosis regulatory protein bcl-2 and bax in endometrium of polycystic ovary syndrome].
Zhonghua Fu Chan Ke Za Zhi. 1999 Nov; 34(11):652-4.ZF

Abstract

OBJECTIVE

To study the expression and implication of apoptosis regulatory protein bcl-2 and bax in endometrium of polycystic ovary syndrome (PCOS).

METHODS

The apoptosis regulatory protein expression of bcl-2 and bax protein in endometrium were investigated by immunohistochemical method in 18 PCOS and 27 normal subjects proliferative phase 10 and secretory phase 17.

RESULTS

Bcl-2 expression was higher in PCOS than that both in control proliferative phase (P < 0.05) and secretory phase (P < 0.001). Bax expression was not significantly different between PCOS and controls (P > 0.05).

CONCLUSIONS

The higher bcl-2 protein expression inhibits the endometrium apoptosis and plays an important role in the abnormal proliferative changes of endometrium in PCOS.

Authors+Show Affiliations

Chen Y
Third Hospital of Beijing Medical University, Beijing 100083.
Wang Y
No affiliation info available
Li M
No affiliation info available

MeSH

AdultApoptosisEndometriumFemaleHumansPolycystic Ovary SyndromeProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2RNA, Messengerbcl-2-Associated X Protein

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11479944

Citation

Chen, Y, et al. "[Expression of Apoptosis Regulatory Protein Bcl-2 and Bax in Endometrium of Polycystic Ovary Syndrome]." Zhonghua Fu Chan Ke Za Zhi, vol. 34, no. 11, 1999, pp. 652-4.
Chen Y, Wang Y, Li M. [Expression of apoptosis regulatory protein bcl-2 and bax in endometrium of polycystic ovary syndrome]. Zhonghua Fu Chan Ke Za Zhi. 1999;34(11):652-4.
Chen, Y., Wang, Y., & Li, M. (1999). [Expression of apoptosis regulatory protein bcl-2 and bax in endometrium of polycystic ovary syndrome]. Zhonghua Fu Chan Ke Za Zhi, 34(11), 652-4.
Chen Y, Wang Y, Li M. [Expression of Apoptosis Regulatory Protein Bcl-2 and Bax in Endometrium of Polycystic Ovary Syndrome]. Zhonghua Fu Chan Ke Za Zhi. 1999;34(11):652-4. PubMed PMID: 11479944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of apoptosis regulatory protein bcl-2 and bax in endometrium of polycystic ovary syndrome]. AU - Chen,Y, AU - Wang,Y, AU - Li,M, PY - 2001/8/2/pubmed PY - 2001/8/17/medline PY - 2001/8/2/entrez SP - 652 EP - 4 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 34 IS - 11 N2 - OBJECTIVE: To study the expression and implication of apoptosis regulatory protein bcl-2 and bax in endometrium of polycystic ovary syndrome (PCOS). METHODS: The apoptosis regulatory protein expression of bcl-2 and bax protein in endometrium were investigated by immunohistochemical method in 18 PCOS and 27 normal subjects proliferative phase 10 and secretory phase 17. RESULTS: Bcl-2 expression was higher in PCOS than that both in control proliferative phase (P < 0.05) and secretory phase (P < 0.001). Bax expression was not significantly different between PCOS and controls (P > 0.05). CONCLUSIONS: The higher bcl-2 protein expression inhibits the endometrium apoptosis and plays an important role in the abnormal proliferative changes of endometrium in PCOS. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/11479944/[Expression_of_apoptosis_regulatory_protein_bcl_2_and_bax_in_endometrium_of_polycystic_ovary_syndrome]_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -