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Hormone-related headache.
Med Clin North Am. 2001 Jul; 85(4):1017-35.MC

Abstract

The normal female life cycle is associated with hormonal milestones including menarche, pregnancy, OC use, menopause, and the use of HRT. Menarche marks the onset of menses and cyclic changes in hormone levels. Pregnancy is associated with rising noncyclic levels of sex hormones. Menopause is associated with declining noncyclic levels. Hormonal OC use during the reproductive years and HRT in menopause are therapeutic hormonal interventions that alter the levels and cycling of sex hormones. These events and interventions may cause a change in the prevalence or intensity of headache. Headaches associated with OC use or menopausal HRT may be related, in part, to periodic discontinuation of oral sex hormone preparations. The treatment of migraine associated with changes in sex hormone levels is difficult, and patients often are refractory to therapy. Based on what is known of the pathophysiology of migraine, a logical approach to the treatment of headaches that are associated with menses, menopause, and OCs using abortive and preventive medications and hormonal manipulations has been presented.

Authors+Show Affiliations

Jefferson Headache Center and Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA. Stephen.Silberstein@mail.tju.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11480256

Citation

Silberstein, S D.. "Hormone-related Headache." The Medical Clinics of North America, vol. 85, no. 4, 2001, pp. 1017-35.
Silberstein SD. Hormone-related headache. Med Clin North Am. 2001;85(4):1017-35.
Silberstein, S. D. (2001). Hormone-related headache. The Medical Clinics of North America, 85(4), 1017-35.
Silberstein SD. Hormone-related Headache. Med Clin North Am. 2001;85(4):1017-35. PubMed PMID: 11480256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormone-related headache. A1 - Silberstein,S D, PY - 2001/8/2/pubmed PY - 2001/8/17/medline PY - 2001/8/2/entrez SP - 1017 EP - 35 JF - The Medical clinics of North America JO - Med Clin North Am VL - 85 IS - 4 N2 - The normal female life cycle is associated with hormonal milestones including menarche, pregnancy, OC use, menopause, and the use of HRT. Menarche marks the onset of menses and cyclic changes in hormone levels. Pregnancy is associated with rising noncyclic levels of sex hormones. Menopause is associated with declining noncyclic levels. Hormonal OC use during the reproductive years and HRT in menopause are therapeutic hormonal interventions that alter the levels and cycling of sex hormones. These events and interventions may cause a change in the prevalence or intensity of headache. Headaches associated with OC use or menopausal HRT may be related, in part, to periodic discontinuation of oral sex hormone preparations. The treatment of migraine associated with changes in sex hormone levels is difficult, and patients often are refractory to therapy. Based on what is known of the pathophysiology of migraine, a logical approach to the treatment of headaches that are associated with menses, menopause, and OCs using abortive and preventive medications and hormonal manipulations has been presented. SN - 0025-7125 UR - https://www.unboundmedicine.com/medline/citation/11480256/Hormone_related_headache_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-7125(05)70357-6 DB - PRIME DP - Unbound Medicine ER -