Tags

Type your tag names separated by a space and hit enter

Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis.
Adv Exp Med Biol 2001; 492:69-81AE

Abstract

Overall, a host of studies provides compelling evidence that garlic and its organic allyl sulfur components are effective inhibitors of the cancer process. These studies reveal that the benefits of garlic are not limited to a specific species, to a particular tissue, or to a specific carcinogen. Several mechanisms are likely to account for this protection. Notable among these is a depression in nitrosamine formation and a reduction in carcinogen bioactivation. The benefits provided by garlic must be viewed as part of the entire diet, since several dietary constituents can influence the degree of protection. More than one compound is responsible for the anticancer properties associated with garlic. Future research should focus on how genetic variability and daily environmental factors influence the anticancer benefits attributed to garlic and its allyl sulfur components.

Authors+Show Affiliations

Nutrition Department, The Pennsylvania State University, University Park, 16802, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

11480676

Citation

Milner, J A.. "Mechanisms By Which Garlic and Allyl Sulfur Compounds Suppress Carcinogen Bioactivation. Garlic and Carcinogenesis." Advances in Experimental Medicine and Biology, vol. 492, 2001, pp. 69-81.
Milner JA. Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis. Adv Exp Med Biol. 2001;492:69-81.
Milner, J. A. (2001). Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis. Advances in Experimental Medicine and Biology, 492, pp. 69-81.
Milner JA. Mechanisms By Which Garlic and Allyl Sulfur Compounds Suppress Carcinogen Bioactivation. Garlic and Carcinogenesis. Adv Exp Med Biol. 2001;492:69-81. PubMed PMID: 11480676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis. A1 - Milner,J A, PY - 2001/8/2/pubmed PY - 2002/4/16/medline PY - 2001/8/2/entrez SP - 69 EP - 81 JF - Advances in experimental medicine and biology JO - Adv. Exp. Med. Biol. VL - 492 N2 - Overall, a host of studies provides compelling evidence that garlic and its organic allyl sulfur components are effective inhibitors of the cancer process. These studies reveal that the benefits of garlic are not limited to a specific species, to a particular tissue, or to a specific carcinogen. Several mechanisms are likely to account for this protection. Notable among these is a depression in nitrosamine formation and a reduction in carcinogen bioactivation. The benefits provided by garlic must be viewed as part of the entire diet, since several dietary constituents can influence the degree of protection. More than one compound is responsible for the anticancer properties associated with garlic. Future research should focus on how genetic variability and daily environmental factors influence the anticancer benefits attributed to garlic and its allyl sulfur components. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/11480676/Mechanisms_by_which_garlic_and_allyl_sulfur_compounds_suppress_carcinogen_bioactivation__Garlic_and_carcinogenesis_ L2 - https://dx.doi.org/10.1007/978-1-4615-1283-7_7 DB - PRIME DP - Unbound Medicine ER -