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Clinical controlled study on plaque and gingivitis reduction under long-term use of low-dose chlorhexidine solutions in a population exhibiting good oral hygiene.
Clin Oral Investig 2001; 5(2):89-95CO

Abstract

The aim of this randomized, parallel-group, placebo-controlled, blind clinical study was to examine the dental plaque and the gingivitis inhibitory effects of two low-dose 0.06% chlorhexidine (CHX) preparations in comparison to a commercially available 0.1% CHX solution, an amine fluoride/stannous fluoride (ASF) solution and a water control as an adjunct to the daily mechanical oral-hygiene measures. After prophylaxis, 81 medical students performed their tooth cleaning and were asked to rinse for 30 s, according to the instructions given by the manufacturers with the assigned amount of the following solutions: once daily 10 ml ASF 250 ppm or twice daily each 10 ml CHX 0.06% with fluoride, 10 ml CHX 0.06% without fluoride, 15 ml CHX 0.1% or 100 ml tap water. The plaque index (PlI), the gingival index (GI) and the discoloration index (DI) were taken at day -14 and months (M) 0, 1, 2, 3 and 6. In this study group with good oral hygiene, all test products led to a reduction of the PlI scores when used as supplements to the usual mechanical hygiene measures. At M3 subjects using both the 0.1% as well as the 0.06% CHX showed significantly less plaque accumulation than those using ASF. In the GI a significant difference between the control and 0.1 % CHX was found at M3 and at M6. If a further decrease in the GI is wanted, a minimum concentration of 0.1% CHX for long-term use in association with habitual cleaning is needed, which, however, should be limited to special patients. If maintaining clinical health is the goal, the other solutions are a good alternative to 0.1% CHX because they exhibit less staining.

Authors+Show Affiliations

Department of Periodontology, Dental School TU Dresden, Germany. th.hoffm@rcs.urz.tu-dresden.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11480815

Citation

Hoffmann, T, et al. "Clinical Controlled Study On Plaque and Gingivitis Reduction Under Long-term Use of Low-dose Chlorhexidine Solutions in a Population Exhibiting Good Oral Hygiene." Clinical Oral Investigations, vol. 5, no. 2, 2001, pp. 89-95.
Hoffmann T, Bruhn G, Richter S, et al. Clinical controlled study on plaque and gingivitis reduction under long-term use of low-dose chlorhexidine solutions in a population exhibiting good oral hygiene. Clin Oral Investig. 2001;5(2):89-95.
Hoffmann, T., Bruhn, G., Richter, S., Netuschil, L., & Brecx, M. (2001). Clinical controlled study on plaque and gingivitis reduction under long-term use of low-dose chlorhexidine solutions in a population exhibiting good oral hygiene. Clinical Oral Investigations, 5(2), pp. 89-95.
Hoffmann T, et al. Clinical Controlled Study On Plaque and Gingivitis Reduction Under Long-term Use of Low-dose Chlorhexidine Solutions in a Population Exhibiting Good Oral Hygiene. Clin Oral Investig. 2001;5(2):89-95. PubMed PMID: 11480815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical controlled study on plaque and gingivitis reduction under long-term use of low-dose chlorhexidine solutions in a population exhibiting good oral hygiene. AU - Hoffmann,T, AU - Bruhn,G, AU - Richter,S, AU - Netuschil,L, AU - Brecx,M, PY - 2001/8/2/pubmed PY - 2001/9/28/medline PY - 2001/8/2/entrez SP - 89 EP - 95 JF - Clinical oral investigations JO - Clin Oral Investig VL - 5 IS - 2 N2 - The aim of this randomized, parallel-group, placebo-controlled, blind clinical study was to examine the dental plaque and the gingivitis inhibitory effects of two low-dose 0.06% chlorhexidine (CHX) preparations in comparison to a commercially available 0.1% CHX solution, an amine fluoride/stannous fluoride (ASF) solution and a water control as an adjunct to the daily mechanical oral-hygiene measures. After prophylaxis, 81 medical students performed their tooth cleaning and were asked to rinse for 30 s, according to the instructions given by the manufacturers with the assigned amount of the following solutions: once daily 10 ml ASF 250 ppm or twice daily each 10 ml CHX 0.06% with fluoride, 10 ml CHX 0.06% without fluoride, 15 ml CHX 0.1% or 100 ml tap water. The plaque index (PlI), the gingival index (GI) and the discoloration index (DI) were taken at day -14 and months (M) 0, 1, 2, 3 and 6. In this study group with good oral hygiene, all test products led to a reduction of the PlI scores when used as supplements to the usual mechanical hygiene measures. At M3 subjects using both the 0.1% as well as the 0.06% CHX showed significantly less plaque accumulation than those using ASF. In the GI a significant difference between the control and 0.1 % CHX was found at M3 and at M6. If a further decrease in the GI is wanted, a minimum concentration of 0.1% CHX for long-term use in association with habitual cleaning is needed, which, however, should be limited to special patients. If maintaining clinical health is the goal, the other solutions are a good alternative to 0.1% CHX because they exhibit less staining. SN - 1432-6981 UR - https://www.unboundmedicine.com/medline/citation/11480815/Clinical_controlled_study_on_plaque_and_gingivitis_reduction_under_long_term_use_of_low_dose_chlorhexidine_solutions_in_a_population_exhibiting_good_oral_hygiene_ L2 - https://medlineplus.gov/dentalhealth.html DB - PRIME DP - Unbound Medicine ER -