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Sensitive determination of pethidine in body fluids by surface ionization organic mass spectrometry.
J Chromatogr B Biomed Sci Appl. 2001 Jul 05; 758(1):117-21.JC

Abstract

We have presented a simple and sensitive method for determining pethidine, a narcotic analgesic drug in body fluids by gas chromatography (GC)/surface ionization organic mass spectrometry (SIOMS). Good linearity was obtained in the range of 0.625-25 ng/ml of whole blood and urine by mass chromatography, and in the range of 0.05-2 ng/ml of whole blood by selected ion monitoring (SIM). Pethidine and diphenylpyraline (internal standard) were extracted from body fluids with Bond Elut Certify cartridges; their recoveries were above 95%. The detection limits (signal-to-noise ratio=3) were estimated to be 0.2 ng/ml of whole blood or urine by mass chromatography, 0.02 ng/ml of whole blood by SIM.

Authors+Show Affiliations

Ishii A
Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, Japan. akishii@med.nagoya-u.ac.jp
Kurihara R
No affiliation info available
Watanabe-Suzuki K
No affiliation info available
Kumazawa T
No affiliation info available
Seno H
No affiliation info available
Matsushima H
No affiliation info available
Suzuki O
No affiliation info available
Katsumata Y
No affiliation info available

MeSH

Analgesics, OpioidBody FluidsHumansMaleMass SpectrometryMeperidineReproducibility of ResultsSensitivity and Specificity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11482730

Citation

Ishii, A, et al. "Sensitive Determination of Pethidine in Body Fluids By Surface Ionization Organic Mass Spectrometry." Journal of Chromatography. B, Biomedical Sciences and Applications, vol. 758, no. 1, 2001, pp. 117-21.
Ishii A, Kurihara R, Watanabe-Suzuki K, et al. Sensitive determination of pethidine in body fluids by surface ionization organic mass spectrometry. J Chromatogr B Biomed Sci Appl. 2001;758(1):117-21.
Ishii, A., Kurihara, R., Watanabe-Suzuki, K., Kumazawa, T., Seno, H., Matsushima, H., Suzuki, O., & Katsumata, Y. (2001). Sensitive determination of pethidine in body fluids by surface ionization organic mass spectrometry. Journal of Chromatography. B, Biomedical Sciences and Applications, 758(1), 117-21.
Ishii A, et al. Sensitive Determination of Pethidine in Body Fluids By Surface Ionization Organic Mass Spectrometry. J Chromatogr B Biomed Sci Appl. 2001 Jul 5;758(1):117-21. PubMed PMID: 11482730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitive determination of pethidine in body fluids by surface ionization organic mass spectrometry. AU - Ishii,A, AU - Kurihara,R, AU - Watanabe-Suzuki,K, AU - Kumazawa,T, AU - Seno,H, AU - Matsushima,H, AU - Suzuki,O, AU - Katsumata,Y, PY - 2001/8/3/pubmed PY - 2002/1/5/medline PY - 2001/8/3/entrez SP - 117 EP - 21 JF - Journal of chromatography. B, Biomedical sciences and applications JO - J Chromatogr B Biomed Sci Appl VL - 758 IS - 1 N2 - We have presented a simple and sensitive method for determining pethidine, a narcotic analgesic drug in body fluids by gas chromatography (GC)/surface ionization organic mass spectrometry (SIOMS). Good linearity was obtained in the range of 0.625-25 ng/ml of whole blood and urine by mass chromatography, and in the range of 0.05-2 ng/ml of whole blood by selected ion monitoring (SIM). Pethidine and diphenylpyraline (internal standard) were extracted from body fluids with Bond Elut Certify cartridges; their recoveries were above 95%. The detection limits (signal-to-noise ratio=3) were estimated to be 0.2 ng/ml of whole blood or urine by mass chromatography, 0.02 ng/ml of whole blood by SIM. SN - 1387-2273 UR - https://www.unboundmedicine.com/medline/citation/11482730/Sensitive_determination_of_pethidine_in_body_fluids_by_surface_ionization_organic_mass_spectrometry_ DB - PRIME DP - Unbound Medicine ER -