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Dietary fat and risk for advanced age-related macular degeneration.

Abstract

OBJECTIVE

To evaluate the relationship between intake of total and specific types of fat and risk for advanced age-related macular degeneration (AMD), the leading cause of irreversible blindness in adults.

DESIGN

A multicenter eye disease case-control study.

SETTING

Five US clinical ophthalmology centers.

PATIENTS

Case subjects included 349 individuals (age range, 55-80 years) with the advanced, neovascular stage of AMD diagnosed within 1 year of their enrollment into the study who resided near a participating clinical center. Control subjects included 504 individuals without AMD but with other ocular diseases. Controls were from the same geographic areas as cases and were frequency-matched to cases by age and sex.

MAIN OUTCOME MEASURES

Relative risk for AMD according to level of fat intake, controlling for cigarette smoking and other risk factors.

RESULTS

Higher vegetable fat consumption was associated with an elevated risk for AMD. After adjusting for age, sex, education, cigarette smoking, and other risk factors, the odds ratio (OR) was 2.22 (95% confidence interval [CI], 1.32-3.74) for persons in the highest vs those in the lowest quintiles of intake (P for trend,.007). The risk for AMD was also significantly elevated for the highest vs lowest quintiles of intake of monounsaturated (OR, 1.71) and polyunsaturated (OR, 1.86) fats (Ps for trend,.03 and.03, respectively). Higher consumption of linoleic acid was also associated with a higher risk for AMD (P for trend,.02). Higher intake of omega-3 fatty acids was associated with a lower risk for AMD among individuals consuming diets low in linoleic acid, an omega-6 fatty acid (P for trend,.05; P for continuous variable,.03). Similarly, higher frequency of fish intake tended to reduce risk for AMD when the diet was low in linoleic acid (P for trend,.05). Conversely, neither omega-3 fatty acids nor fish intake were related to risk for AMD among people with high levels of linoleic acid intake.

CONCLUSION

Higher intake of specific types of fat--including vegetable, monounsaturated, and polyunsaturated fats and linoleic acid--rather than total fat intake may be associated with a greater risk for advanced AMD. Diets high in omega-3 fatty acids and fish were inversely associated with risk for AMD when intake of linoleic acid was low.

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  • Authors+Show Affiliations

    ,

    Epidemiology Unit, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA. Johanna_Seddon@meei.harvard.edu

    , , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Case-Control Studies
    Diet Records
    Dietary Fats
    Fatty Acids, Monounsaturated
    Fatty Acids, Omega-3
    Fatty Acids, Unsaturated
    Feeding Behavior
    Female
    Humans
    Linoleic Acid
    Macular Degeneration
    Male
    Middle Aged
    Odds Ratio
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11483088

    Citation

    Seddon, J M., et al. "Dietary Fat and Risk for Advanced Age-related Macular Degeneration." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 119, no. 8, 2001, pp. 1191-9.
    Seddon JM, Rosner B, Sperduto RD, et al. Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol. 2001;119(8):1191-9.
    Seddon, J. M., Rosner, B., Sperduto, R. D., Yannuzzi, L., Haller, J. A., Blair, N. P., & Willett, W. (2001). Dietary fat and risk for advanced age-related macular degeneration. Archives of Ophthalmology (Chicago, Ill. : 1960), 119(8), pp. 1191-9.
    Seddon JM, et al. Dietary Fat and Risk for Advanced Age-related Macular Degeneration. Arch Ophthalmol. 2001;119(8):1191-9. PubMed PMID: 11483088.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fat and risk for advanced age-related macular degeneration. AU - Seddon,J M, AU - Rosner,B, AU - Sperduto,R D, AU - Yannuzzi,L, AU - Haller,J A, AU - Blair,N P, AU - Willett,W, PY - 2001/8/14/pubmed PY - 2001/8/24/medline PY - 2001/8/14/entrez SP - 1191 EP - 9 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 119 IS - 8 N2 - OBJECTIVE: To evaluate the relationship between intake of total and specific types of fat and risk for advanced age-related macular degeneration (AMD), the leading cause of irreversible blindness in adults. DESIGN: A multicenter eye disease case-control study. SETTING: Five US clinical ophthalmology centers. PATIENTS: Case subjects included 349 individuals (age range, 55-80 years) with the advanced, neovascular stage of AMD diagnosed within 1 year of their enrollment into the study who resided near a participating clinical center. Control subjects included 504 individuals without AMD but with other ocular diseases. Controls were from the same geographic areas as cases and were frequency-matched to cases by age and sex. MAIN OUTCOME MEASURES: Relative risk for AMD according to level of fat intake, controlling for cigarette smoking and other risk factors. RESULTS: Higher vegetable fat consumption was associated with an elevated risk for AMD. After adjusting for age, sex, education, cigarette smoking, and other risk factors, the odds ratio (OR) was 2.22 (95% confidence interval [CI], 1.32-3.74) for persons in the highest vs those in the lowest quintiles of intake (P for trend,.007). The risk for AMD was also significantly elevated for the highest vs lowest quintiles of intake of monounsaturated (OR, 1.71) and polyunsaturated (OR, 1.86) fats (Ps for trend,.03 and.03, respectively). Higher consumption of linoleic acid was also associated with a higher risk for AMD (P for trend,.02). Higher intake of omega-3 fatty acids was associated with a lower risk for AMD among individuals consuming diets low in linoleic acid, an omega-6 fatty acid (P for trend,.05; P for continuous variable,.03). Similarly, higher frequency of fish intake tended to reduce risk for AMD when the diet was low in linoleic acid (P for trend,.05). Conversely, neither omega-3 fatty acids nor fish intake were related to risk for AMD among people with high levels of linoleic acid intake. CONCLUSION: Higher intake of specific types of fat--including vegetable, monounsaturated, and polyunsaturated fats and linoleic acid--rather than total fat intake may be associated with a greater risk for advanced AMD. Diets high in omega-3 fatty acids and fish were inversely associated with risk for AMD when intake of linoleic acid was low. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/11483088/Dietary_fat_and_risk_for_advanced_age_related_macular_degeneration_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/119/pg/1191 DB - PRIME DP - Unbound Medicine ER -