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Prevalence of coeliac disease in siblings of patients with Type I diabetes is related to the prevalence of DQB1*02 allele.
Diabetologia. 2001 Aug; 44(8):1051-3.D

Abstract

AIMS/HYPOTHESIS

Coeliac disease is more prevalent among patients with Type I (insulin-dependent) diabetes mellitus and coeliac disease-related antibodies have been reported to increase in frequency in their first-degree relatives. Our aim was to find out if coeliac disease is more common among siblings of children with Type I diabetes than in the normal population.

METHODS

IgA endomysium antibodies were measured by indirect immunofluorescence in 550 subjects (mean age 11.8 years, range 3.1-26.9 years) with a sibling with Type I diabetes. We performed jejunal biopsy on as many subjects with positive antibodies as agreed. HLA-DQB1 genotyping was done in 427 subjects.

RESULTS

Endomysium antibodies were positive in nine subjects (1.6 %). Jejunal biopsy was diagnostic for coeliac disease in five out of seven patients. An additional patient with coeliac disease, one already on a gluten-free diet, was identified by questionnaire. The prevalence of coeliac disease was 1.1 %. Five of six patients with coeliac disease had HLA-DQB1*02 allele, compared with 118 of 421 of those without coeliac disease (p = 0.009). The sixth patient was positive for HLA-DQB1*0302 allele, which was also found in 241 of 421 of those without coeliac disease (p = 0.4).

CONCLUSION/INTERPRETATION

We found the prevalence of coeliac disease among siblings of children with Type I diabetes to be similar to figures reported from recent population-based studies and to be correlated with the prevalence of coeliac disease associated HLA-DQB1 alleles. We propose that routine screening for coeliac disease among all first-degree relatives of patients with Type I diabetes is not warranted.

Authors+Show Affiliations

Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. tero.saukkonen@hus.fiNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11484084

Citation

Saukkonen, T, et al. "Prevalence of Coeliac Disease in Siblings of Patients With Type I Diabetes Is Related to the Prevalence of DQB1*02 Allele." Diabetologia, vol. 44, no. 8, 2001, pp. 1051-3.
Saukkonen T, Ilonen J, Akerblom HK, et al. Prevalence of coeliac disease in siblings of patients with Type I diabetes is related to the prevalence of DQB1*02 allele. Diabetologia. 2001;44(8):1051-3.
Saukkonen, T., Ilonen, J., Akerblom, H. K., & Savilahti, E. (2001). Prevalence of coeliac disease in siblings of patients with Type I diabetes is related to the prevalence of DQB1*02 allele. Diabetologia, 44(8), 1051-3.
Saukkonen T, et al. Prevalence of Coeliac Disease in Siblings of Patients With Type I Diabetes Is Related to the Prevalence of DQB1*02 Allele. Diabetologia. 2001;44(8):1051-3. PubMed PMID: 11484084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of coeliac disease in siblings of patients with Type I diabetes is related to the prevalence of DQB1*02 allele. AU - Saukkonen,T, AU - Ilonen,J, AU - Akerblom,H K, AU - Savilahti,E, PY - 2001/8/3/pubmed PY - 2001/10/26/medline PY - 2001/8/3/entrez SP - 1051 EP - 3 JF - Diabetologia JO - Diabetologia VL - 44 IS - 8 N2 - AIMS/HYPOTHESIS: Coeliac disease is more prevalent among patients with Type I (insulin-dependent) diabetes mellitus and coeliac disease-related antibodies have been reported to increase in frequency in their first-degree relatives. Our aim was to find out if coeliac disease is more common among siblings of children with Type I diabetes than in the normal population. METHODS: IgA endomysium antibodies were measured by indirect immunofluorescence in 550 subjects (mean age 11.8 years, range 3.1-26.9 years) with a sibling with Type I diabetes. We performed jejunal biopsy on as many subjects with positive antibodies as agreed. HLA-DQB1 genotyping was done in 427 subjects. RESULTS: Endomysium antibodies were positive in nine subjects (1.6 %). Jejunal biopsy was diagnostic for coeliac disease in five out of seven patients. An additional patient with coeliac disease, one already on a gluten-free diet, was identified by questionnaire. The prevalence of coeliac disease was 1.1 %. Five of six patients with coeliac disease had HLA-DQB1*02 allele, compared with 118 of 421 of those without coeliac disease (p = 0.009). The sixth patient was positive for HLA-DQB1*0302 allele, which was also found in 241 of 421 of those without coeliac disease (p = 0.4). CONCLUSION/INTERPRETATION: We found the prevalence of coeliac disease among siblings of children with Type I diabetes to be similar to figures reported from recent population-based studies and to be correlated with the prevalence of coeliac disease associated HLA-DQB1 alleles. We propose that routine screening for coeliac disease among all first-degree relatives of patients with Type I diabetes is not warranted. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/11484084/Prevalence_of_coeliac_disease_in_siblings_of_patients_with_Type_I_diabetes_is_related_to_the_prevalence_of_DQB1_02_allele_ L2 - https://doi.org/10.1007/s001250100591 DB - PRIME DP - Unbound Medicine ER -