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Evaluation of a newly developed dipstick test for the rapid diagnosis of scrub typhus in febrile patients.

Abstract

Scrub typhus is a potentially fatal, febrile disease prevalent in rural Asia. The etiological agent, Orientia tsutsugamushi, is transmitted to humans by the bite of a larval trombiculid mite. No current diagnostic test is sufficiently practical for use by physicians working in rural areas. A new dipstick test using a dot blot immunoassay format has been developed for the serodiagnosis of scrub typhus. We evaluated this test on 83 patients presenting with acute fever of unknown origin at Maharaj Hospital, a tertiary care medical center in Nakhon Ratchasima, Northeast Thailand. The diagnosis of scrub typhus was confirmed in 30 of these patients (36%) by the indirect immunoperoxidase test. The sensitivity of the test was 87% and its specificity was 94%. The dot blot immunoassay dipstick is accurate, rapid, easy to use, and relatively inexpensive. It appears to be the best currently available test for diagnosing scrub typhus in rural areas where this disease predominates.

Authors+Show Affiliations

Department of Medicine, Maharaj Nakhon Ratchasima Hospital, Nakhon Ratchasima, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

11485073

Citation

Chinprasatsak, S, et al. "Evaluation of a Newly Developed Dipstick Test for the Rapid Diagnosis of Scrub Typhus in Febrile Patients." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 32, no. 1, 2001, pp. 132-6.
Chinprasatsak S, Wilairatana P, Looareesuwan S, et al. Evaluation of a newly developed dipstick test for the rapid diagnosis of scrub typhus in febrile patients. Southeast Asian J Trop Med Public Health. 2001;32(1):132-6.
Chinprasatsak, S., Wilairatana, P., Looareesuwan, S., Chappuis, F., Akkhavong, K., Laferl, H., & Eamsila, C. (2001). Evaluation of a newly developed dipstick test for the rapid diagnosis of scrub typhus in febrile patients. The Southeast Asian Journal of Tropical Medicine and Public Health, 32(1), pp. 132-6.
Chinprasatsak S, et al. Evaluation of a Newly Developed Dipstick Test for the Rapid Diagnosis of Scrub Typhus in Febrile Patients. Southeast Asian J Trop Med Public Health. 2001;32(1):132-6. PubMed PMID: 11485073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of a newly developed dipstick test for the rapid diagnosis of scrub typhus in febrile patients. AU - Chinprasatsak,S, AU - Wilairatana,P, AU - Looareesuwan,S, AU - Chappuis,F, AU - Akkhavong,K, AU - Laferl,H, AU - Eamsila,C, PY - 2001/8/4/pubmed PY - 2002/1/5/medline PY - 2001/8/4/entrez SP - 132 EP - 6 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J. Trop. Med. Public Health VL - 32 IS - 1 N2 - Scrub typhus is a potentially fatal, febrile disease prevalent in rural Asia. The etiological agent, Orientia tsutsugamushi, is transmitted to humans by the bite of a larval trombiculid mite. No current diagnostic test is sufficiently practical for use by physicians working in rural areas. A new dipstick test using a dot blot immunoassay format has been developed for the serodiagnosis of scrub typhus. We evaluated this test on 83 patients presenting with acute fever of unknown origin at Maharaj Hospital, a tertiary care medical center in Nakhon Ratchasima, Northeast Thailand. The diagnosis of scrub typhus was confirmed in 30 of these patients (36%) by the indirect immunoperoxidase test. The sensitivity of the test was 87% and its specificity was 94%. The dot blot immunoassay dipstick is accurate, rapid, easy to use, and relatively inexpensive. It appears to be the best currently available test for diagnosing scrub typhus in rural areas where this disease predominates. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/11485073/Evaluation_of_a_newly_developed_dipstick_test_for_the_rapid_diagnosis_of_scrub_typhus_in_febrile_patients_ L2 - http://www.diseaseinfosearch.org/result/7277 DB - PRIME DP - Unbound Medicine ER -