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Bactericidal and cytotoxic effects of sodium hypochlorite and sodium dichloroisocyanurate solutions in vitro.
J Endod. 2001 Apr; 27(4):278-80.JE

Abstract

The antimicrobial and cytotoxic effects of sodium hypochlorite (NaOCl) and sodium dichloroisocyanurate (NaDCC) were evaluated and compared in vitro. The minimal inhibitory concentration and minimal bactericidal concentration of NaOCl and NaDCC were tested for Streptococcus sobrinus, Streptococcus salivarius, Enterococcus faecalis, and Streptococcus mutans. The cytotoxic effect was assessed by using human fibroblast tissue culture. Survival rate was assessed by a protein determination method. Results showed that the minimal inhibitory concentration and minimal bactericidal concentration values of NaOCl and NaDCC for the tested bacteria were in a similar range. NaDCC in concentrations higher than 0.02%, and NaOCl in concentrations higher than 0.01% were lethal to fibroblasts. In conclusion it seems that both agents were very effective in killing bacteria, and their cytotoxicity to fibroblasts in tissue culture was similar.

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Authors+Show Affiliations

Heling I
Department of Endodontics, The Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem, Israel.
Rotstein I
No affiliation info available
Dinur T
No affiliation info available
Szwec-Levine Y
No affiliation info available
Steinberg D
No affiliation info available

MeSH

Anti-Infective Agents, LocalCell SurvivalChlorineCulture TechniquesDisinfectantsEnterococcus faecalisFibroblastsHumansMicrobial Sensitivity TestsSkinSodium HypochloriteStreptococcusStreptococcus mutansStreptococcus sobrinusTriazines

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11485267

Citation

Heling, I, et al. "Bactericidal and Cytotoxic Effects of Sodium Hypochlorite and Sodium Dichloroisocyanurate Solutions in Vitro." Journal of Endodontics, vol. 27, no. 4, 2001, pp. 278-80.
Heling I, Rotstein I, Dinur T, et al. Bactericidal and cytotoxic effects of sodium hypochlorite and sodium dichloroisocyanurate solutions in vitro. J Endod. 2001;27(4):278-80.
Heling, I., Rotstein, I., Dinur, T., Szwec-Levine, Y., & Steinberg, D. (2001). Bactericidal and cytotoxic effects of sodium hypochlorite and sodium dichloroisocyanurate solutions in vitro. Journal of Endodontics, 27(4), 278-80.
Heling I, et al. Bactericidal and Cytotoxic Effects of Sodium Hypochlorite and Sodium Dichloroisocyanurate Solutions in Vitro. J Endod. 2001;27(4):278-80. PubMed PMID: 11485267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bactericidal and cytotoxic effects of sodium hypochlorite and sodium dichloroisocyanurate solutions in vitro. AU - Heling,I, AU - Rotstein,I, AU - Dinur,T, AU - Szwec-Levine,Y, AU - Steinberg,D, PY - 2001/8/4/pubmed PY - 2001/9/28/medline PY - 2001/8/4/entrez SP - 278 EP - 80 JF - Journal of endodontics JO - J Endod VL - 27 IS - 4 N2 - The antimicrobial and cytotoxic effects of sodium hypochlorite (NaOCl) and sodium dichloroisocyanurate (NaDCC) were evaluated and compared in vitro. The minimal inhibitory concentration and minimal bactericidal concentration of NaOCl and NaDCC were tested for Streptococcus sobrinus, Streptococcus salivarius, Enterococcus faecalis, and Streptococcus mutans. The cytotoxic effect was assessed by using human fibroblast tissue culture. Survival rate was assessed by a protein determination method. Results showed that the minimal inhibitory concentration and minimal bactericidal concentration values of NaOCl and NaDCC for the tested bacteria were in a similar range. NaDCC in concentrations higher than 0.02%, and NaOCl in concentrations higher than 0.01% were lethal to fibroblasts. In conclusion it seems that both agents were very effective in killing bacteria, and their cytotoxicity to fibroblasts in tissue culture was similar. SN - 0099-2399 UR - https://www.unboundmedicine.com/medline/citation/11485267/Bactericidal_and_cytotoxic_effects_of_sodium_hypochlorite_and_sodium_dichloroisocyanurate_solutions_in_vitro_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0099-2399(05)60747-9 DB - PRIME DP - Unbound Medicine ER -