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[Antiganglioside antibodies: when, which and for what].
Neurologia. 2001 Aug-Sep; 16(7):293-7.N

Abstract

BACKGROUND

We report our experience in the study of antiganglioside antibodies and define their clinical value establishing associations between clinical syndromes and immunological findings.

METHODS

We analysed 275 sera: Guillain-Barré syndrome (GBS) (78), Miller-Fisher syndrome (MFS) (37), chronic inflammatory demyelinating polyneuroapthy (CIDP) (17), multifocal motor neuropathy (NMM) (42), chronic axonal mixed polyneuropathy (PNP) (54), amyotrophic lateral sclerosis (ALS) (28) and lower motor neuron disease (LMND) (17). We have studied the presence of IgG and IgM antibodies to 9 gangliosides using ELISA and TLC.

RESULTS

We have detected anti-GQ1b antibodies in 36/37 (97,3%) of patients with MFS, being undetectable after 4 weeks in 83%. A 34 % (26/78) of patients with GBS were positive for several antiganglioside specificities being GalGalNAc the most frequent (54%). Two out of three sera positive for GD1a corresponded to axonal Guillain-Barré. IgM class anti-GM1 antibodies were positive in 10/12 patients with MMN, while only a 3-9% of patients with ALS, CIDP, PNP and LMND presented antiganglioside antibodies.

CONCLUSIONS

Analysis of anti-GQ1b antibodies confirms the diagnosis of MFS, excluding other acute brainstem pathologies and, in this study, detection of anti-GD1a antibodies indicates axonal damage in GBS and suggest a worse prognosis. IgM anti-GM1 antibodies are only found in MMN. These findings confirm a disease specific correlation between specific neuropathies and antiganglioside antibodies clinically useful.

Authors+Show Affiliations

Servicio de Neurología. Hospital de la Santa Creu i Sant Pau. Barcelona.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

11485721

Citation

Gallardo, E, et al. "[Antiganglioside Antibodies: When, Which and for What]." Neurologia (Barcelona, Spain), vol. 16, no. 7, 2001, pp. 293-7.
Gallardo E, Rojas-García R, Belvís R, et al. [Antiganglioside antibodies: when, which and for what]. Neurologia. 2001;16(7):293-7.
Gallardo, E., Rojas-García, R., Belvís, R., Serrano-Munuera, C., Ortiz, E., Ortiz, N., Grau, J., & Illa, I. (2001). [Antiganglioside antibodies: when, which and for what]. Neurologia (Barcelona, Spain), 16(7), 293-7.
Gallardo E, et al. [Antiganglioside Antibodies: When, Which and for What]. Neurologia. 2001 Aug-Sep;16(7):293-7. PubMed PMID: 11485721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antiganglioside antibodies: when, which and for what]. AU - Gallardo,E, AU - Rojas-García,R, AU - Belvís,R, AU - Serrano-Munuera,C, AU - Ortiz,E, AU - Ortiz,N, AU - Grau,J, AU - Illa,I, PY - 2001/8/4/pubmed PY - 2002/1/23/medline PY - 2001/8/4/entrez SP - 293 EP - 7 JF - Neurologia (Barcelona, Spain) JO - Neurologia VL - 16 IS - 7 N2 - BACKGROUND: We report our experience in the study of antiganglioside antibodies and define their clinical value establishing associations between clinical syndromes and immunological findings. METHODS: We analysed 275 sera: Guillain-Barré syndrome (GBS) (78), Miller-Fisher syndrome (MFS) (37), chronic inflammatory demyelinating polyneuroapthy (CIDP) (17), multifocal motor neuropathy (NMM) (42), chronic axonal mixed polyneuropathy (PNP) (54), amyotrophic lateral sclerosis (ALS) (28) and lower motor neuron disease (LMND) (17). We have studied the presence of IgG and IgM antibodies to 9 gangliosides using ELISA and TLC. RESULTS: We have detected anti-GQ1b antibodies in 36/37 (97,3%) of patients with MFS, being undetectable after 4 weeks in 83%. A 34 % (26/78) of patients with GBS were positive for several antiganglioside specificities being GalGalNAc the most frequent (54%). Two out of three sera positive for GD1a corresponded to axonal Guillain-Barré. IgM class anti-GM1 antibodies were positive in 10/12 patients with MMN, while only a 3-9% of patients with ALS, CIDP, PNP and LMND presented antiganglioside antibodies. CONCLUSIONS: Analysis of anti-GQ1b antibodies confirms the diagnosis of MFS, excluding other acute brainstem pathologies and, in this study, detection of anti-GD1a antibodies indicates axonal damage in GBS and suggest a worse prognosis. IgM anti-GM1 antibodies are only found in MMN. These findings confirm a disease specific correlation between specific neuropathies and antiganglioside antibodies clinically useful. SN - 0213-4853 UR - https://www.unboundmedicine.com/medline/citation/11485721/[Antiganglioside_antibodies:_when_which_and_for_what]_ DB - PRIME DP - Unbound Medicine ER -