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Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Immunogenetics. 2001 Jul; 53(5):410-5.I

Abstract

Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) in rats closely mimics the human disease multiple sclerosis (MS). As in MS, genetic predisposition to MOG-EAE is regulated by both MHC and non-MHC genes. Based on disease regulatory influences on MOG-EAE on chromosome 10 in an F2 cross between susceptible DA and resistant ACI rats, we have now isolated this locus in a congenic rat strain to enable further dissection of disease mechanisms. This region is of particular interest, since it is homologous to human 17q for which human whole-genome scans have indicated harbors genes regulating susceptibility to MS. Phenotypic comparison between DA and the congenic DA.ACI-D10Rat2-D10Rat29 strain confirms that the chromosomal segment harbors gene(s) conferring strong protection against MOG-EAE. Furthermore, resistance to EAE in this congenic strain is associated with absence or a low level of inflammation and demyelination in the central nervous system. Levels of anti-MOG antibody isotypes did not differ between parental and congenic rats, thus an action on Th1/Th2 differentiation is unlikely. In conclusion, this is the first example of an EAE-regulating locus isolated in a congenic rat strain with retained phenotype. The mechanism by which gene(s) in the region act is still unclear and will require further studies with this congenic rat strain as a tool.

Authors+Show Affiliations

Neuroimmunology Unit, Center for Molecular Medicine, L8:04, Karolinska Hospital, 17176 Stockholm, Sweden. maja.jagodic@cmm.ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11486278

Citation

Jagodic, M, et al. "Congenic Mapping Confirms a Locus On Rat Chromosome 10 Conferring Strong Protection Against Myelin Oligodendrocyte Glycoprotein-induced Experimental Autoimmune Encephalomyelitis." Immunogenetics, vol. 53, no. 5, 2001, pp. 410-5.
Jagodic M, Kornek B, Weissert R, et al. Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Immunogenetics. 2001;53(5):410-5.
Jagodic, M., Kornek, B., Weissert, R., Lassmann, H., Olsson, T., & Dahlman, I. (2001). Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Immunogenetics, 53(5), 410-5.
Jagodic M, et al. Congenic Mapping Confirms a Locus On Rat Chromosome 10 Conferring Strong Protection Against Myelin Oligodendrocyte Glycoprotein-induced Experimental Autoimmune Encephalomyelitis. Immunogenetics. 2001;53(5):410-5. PubMed PMID: 11486278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. AU - Jagodic,M, AU - Kornek,B, AU - Weissert,R, AU - Lassmann,H, AU - Olsson,T, AU - Dahlman,I, PY - 2001/02/19/received PY - 2001/8/7/pubmed PY - 2001/10/19/medline PY - 2001/8/7/entrez SP - 410 EP - 5 JF - Immunogenetics JO - Immunogenetics VL - 53 IS - 5 N2 - Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) in rats closely mimics the human disease multiple sclerosis (MS). As in MS, genetic predisposition to MOG-EAE is regulated by both MHC and non-MHC genes. Based on disease regulatory influences on MOG-EAE on chromosome 10 in an F2 cross between susceptible DA and resistant ACI rats, we have now isolated this locus in a congenic rat strain to enable further dissection of disease mechanisms. This region is of particular interest, since it is homologous to human 17q for which human whole-genome scans have indicated harbors genes regulating susceptibility to MS. Phenotypic comparison between DA and the congenic DA.ACI-D10Rat2-D10Rat29 strain confirms that the chromosomal segment harbors gene(s) conferring strong protection against MOG-EAE. Furthermore, resistance to EAE in this congenic strain is associated with absence or a low level of inflammation and demyelination in the central nervous system. Levels of anti-MOG antibody isotypes did not differ between parental and congenic rats, thus an action on Th1/Th2 differentiation is unlikely. In conclusion, this is the first example of an EAE-regulating locus isolated in a congenic rat strain with retained phenotype. The mechanism by which gene(s) in the region act is still unclear and will require further studies with this congenic rat strain as a tool. SN - 0093-7711 UR - https://www.unboundmedicine.com/medline/citation/11486278/Congenic_mapping_confirms_a_locus_on_rat_chromosome_10_conferring_strong_protection_against_myelin_oligodendrocyte_glycoprotein_induced_experimental_autoimmune_encephalomyelitis_ L2 - https://dx.doi.org/10.1007/s002510100342 DB - PRIME DP - Unbound Medicine ER -