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Antiphospholipid syndrome: diagnostic aspects of lupus anticoagulants.
Thromb Haemost. 2001 Jul; 86(1):83-91.TH

Abstract

Antiphospholipid syndrome (APS) is an autoimmune disorder in which antiphospholipid antibodies (aPL) are thought to be involved in the development of venous and/or arterial thrombosis. APL found in this syndrome are antibodies directed against a variety of phospholipid (PL) binding-proteins of which beta3-glycoprotein I (beta2GPI) and prothrombin are considered to be the major antigens. Some of these antibodies prolong PL-dependent clotting reactions and are termed lupus anticoagulants (LA). Autoimmune aPL which bind through beta2GPI to cardiolipin are called anticardiolipin antibodies (aCL). Clinical studies indicate that LA is a stronger risk factor for thrombosis than aCL. The production of monoclonal antibodies against beta2GPI and prothrombin has enabled us to understand the mechanism by which LA prolong coagulation in vitro. LA form bivalent antigen-antibody complexes with increased affinity for PL which compete with coagulation factors for the same catalytic surface. These LA positive monoclonal antibodies may be helpful in further improving the laboratory diagnosis of LA.

Authors+Show Affiliations

Center for Molecular and Vascular Biology, University of Leuven, Belgium. jef.arnout@med.kuleuven.ac.be

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11487046

Citation

Arnout, J. "Antiphospholipid Syndrome: Diagnostic Aspects of Lupus Anticoagulants." Thrombosis and Haemostasis, vol. 86, no. 1, 2001, pp. 83-91.
Arnout J. Antiphospholipid syndrome: diagnostic aspects of lupus anticoagulants. Thromb Haemost. 2001;86(1):83-91.
Arnout, J. (2001). Antiphospholipid syndrome: diagnostic aspects of lupus anticoagulants. Thrombosis and Haemostasis, 86(1), 83-91.
Arnout J. Antiphospholipid Syndrome: Diagnostic Aspects of Lupus Anticoagulants. Thromb Haemost. 2001;86(1):83-91. PubMed PMID: 11487046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiphospholipid syndrome: diagnostic aspects of lupus anticoagulants. A1 - Arnout,J, PY - 2001/8/7/pubmed PY - 2002/1/23/medline PY - 2001/8/7/entrez SP - 83 EP - 91 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 86 IS - 1 N2 - Antiphospholipid syndrome (APS) is an autoimmune disorder in which antiphospholipid antibodies (aPL) are thought to be involved in the development of venous and/or arterial thrombosis. APL found in this syndrome are antibodies directed against a variety of phospholipid (PL) binding-proteins of which beta3-glycoprotein I (beta2GPI) and prothrombin are considered to be the major antigens. Some of these antibodies prolong PL-dependent clotting reactions and are termed lupus anticoagulants (LA). Autoimmune aPL which bind through beta2GPI to cardiolipin are called anticardiolipin antibodies (aCL). Clinical studies indicate that LA is a stronger risk factor for thrombosis than aCL. The production of monoclonal antibodies against beta2GPI and prothrombin has enabled us to understand the mechanism by which LA prolong coagulation in vitro. LA form bivalent antigen-antibody complexes with increased affinity for PL which compete with coagulation factors for the same catalytic surface. These LA positive monoclonal antibodies may be helpful in further improving the laboratory diagnosis of LA. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/11487046/Antiphospholipid_syndrome:_diagnostic_aspects_of_lupus_anticoagulants_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=11487046.ui DB - PRIME DP - Unbound Medicine ER -