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Subcutaneous continuous apomorphine infusion in fluctuating patients with Parkinson's disease: long-term results.
Neurol Sci. 2001 Feb; 22(1):93-4.NS

Abstract

Fluctuations in motor disability and dyskinesias are the major problem in the long-term treatment of Parkinson's disease (PD). Many authors and ourselves have shown that by giving patients a continuous infusion of levodopa it is possible to control motor fluctuations. Levodopa can be administered continuously only by intravenous, intragastric or intrajejunal delivery. Continuous dopaminergic stimulation can be achieved more easily by infusing dopamine agonists subcutaneously. Apomorphine is a potent water-soluble dopamine receptor agonist that has been shown to successfully control motor fluctuation when subcutaneously infused in complicated parkinsonian patients. We report the clinical data of 30 PD patients having at least five years of treatment with subcutaneous continuous apomorphine infusion.

Authors+Show Affiliations

Department of Neurosciences, University of Rome La Sapienza, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

11487217

Citation

Stocchi, F, et al. "Subcutaneous Continuous Apomorphine Infusion in Fluctuating Patients With Parkinson's Disease: Long-term Results." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 22, no. 1, 2001, pp. 93-4.
Stocchi F, Vacca L, De Pandis MF, et al. Subcutaneous continuous apomorphine infusion in fluctuating patients with Parkinson's disease: long-term results. Neurol Sci. 2001;22(1):93-4.
Stocchi, F., Vacca, L., De Pandis, M. F., Barbato, L., Valente, M., & Ruggieri, S. (2001). Subcutaneous continuous apomorphine infusion in fluctuating patients with Parkinson's disease: long-term results. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 22(1), 93-4.
Stocchi F, et al. Subcutaneous Continuous Apomorphine Infusion in Fluctuating Patients With Parkinson's Disease: Long-term Results. Neurol Sci. 2001;22(1):93-4. PubMed PMID: 11487217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subcutaneous continuous apomorphine infusion in fluctuating patients with Parkinson's disease: long-term results. AU - Stocchi,F, AU - Vacca,L, AU - De Pandis,M F, AU - Barbato,L, AU - Valente,M, AU - Ruggieri,S, PY - 2001/8/7/pubmed PY - 2002/1/5/medline PY - 2001/8/7/entrez SP - 93 EP - 4 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 22 IS - 1 N2 - Fluctuations in motor disability and dyskinesias are the major problem in the long-term treatment of Parkinson's disease (PD). Many authors and ourselves have shown that by giving patients a continuous infusion of levodopa it is possible to control motor fluctuations. Levodopa can be administered continuously only by intravenous, intragastric or intrajejunal delivery. Continuous dopaminergic stimulation can be achieved more easily by infusing dopamine agonists subcutaneously. Apomorphine is a potent water-soluble dopamine receptor agonist that has been shown to successfully control motor fluctuation when subcutaneously infused in complicated parkinsonian patients. We report the clinical data of 30 PD patients having at least five years of treatment with subcutaneous continuous apomorphine infusion. SN - 1590-1874 UR - https://www.unboundmedicine.com/medline/citation/11487217/Subcutaneous_continuous_apomorphine_infusion_in_fluctuating_patients_with_Parkinson's_disease:_long_term_results_ L2 - https://link.springer.com/10.1007/s100720170062 DB - PRIME DP - Unbound Medicine ER -