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Dietary fat, cholesterol and colorectal cancer in a prospective study.
Br J Cancer. 2001 Aug 03; 85(3):357-61.BJ

Abstract

The relationships between consumption of total fat, major dietary fatty acids, cholesterol, consumption of meat and eggs, and the incidence of colorectal cancers were studied in a cohort based on the Finnish Mobile Clinic Health Examination Survey. Baseline (1967-1972) information on habitual food consumption over the preceding year was collected from 9959 men and women free of diagnosed cancer. A total of 109 new colorectal cancer cases were ascertained late 1999. High cholesterol intake was associated with increased risk for colorectal cancers. The relative risk between the highest and lowest quartiles of dietary cholesterol was 3.26 (95% confidence interval 1.54-6.88) after adjusting for age, sex, body mass index, occupation, smoking, geographic region, energy intake and consumption of vegetables, fruits and cereals. Consumption of total fat and intake of saturated, monounsaturated, or polyunsaturated fatty acids were not significantly associated with colorectal cancer risk. Nonsignificant associations were found between consumption of meat and eggs and colorectal cancer risk. The results of the present study indicate that high cholesterol intake may increase colorectal cancer risk, but do not suggest the presence of significant effects of dietary fat intake on colorectal cancer incidence.

Authors+Show Affiliations

Department of Clinical Nutrition, University of Kuopio, P.O. Box 1627, Kuopio, FIN-70211, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11487265

Citation

Järvinen, R, et al. "Dietary Fat, Cholesterol and Colorectal Cancer in a Prospective Study." British Journal of Cancer, vol. 85, no. 3, 2001, pp. 357-61.
Järvinen R, Knekt P, Hakulinen T, et al. Dietary fat, cholesterol and colorectal cancer in a prospective study. Br J Cancer. 2001;85(3):357-61.
Järvinen, R., Knekt, P., Hakulinen, T., Rissanen, H., & Heliövaara, M. (2001). Dietary fat, cholesterol and colorectal cancer in a prospective study. British Journal of Cancer, 85(3), 357-61.
Järvinen R, et al. Dietary Fat, Cholesterol and Colorectal Cancer in a Prospective Study. Br J Cancer. 2001 Aug 3;85(3):357-61. PubMed PMID: 11487265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fat, cholesterol and colorectal cancer in a prospective study. AU - Järvinen,R, AU - Knekt,P, AU - Hakulinen,T, AU - Rissanen,H, AU - Heliövaara,M, PY - 2001/8/7/pubmed PY - 2001/9/8/medline PY - 2001/8/7/entrez SP - 357 EP - 61 JF - British journal of cancer JO - Br. J. Cancer VL - 85 IS - 3 N2 - The relationships between consumption of total fat, major dietary fatty acids, cholesterol, consumption of meat and eggs, and the incidence of colorectal cancers were studied in a cohort based on the Finnish Mobile Clinic Health Examination Survey. Baseline (1967-1972) information on habitual food consumption over the preceding year was collected from 9959 men and women free of diagnosed cancer. A total of 109 new colorectal cancer cases were ascertained late 1999. High cholesterol intake was associated with increased risk for colorectal cancers. The relative risk between the highest and lowest quartiles of dietary cholesterol was 3.26 (95% confidence interval 1.54-6.88) after adjusting for age, sex, body mass index, occupation, smoking, geographic region, energy intake and consumption of vegetables, fruits and cereals. Consumption of total fat and intake of saturated, monounsaturated, or polyunsaturated fatty acids were not significantly associated with colorectal cancer risk. Nonsignificant associations were found between consumption of meat and eggs and colorectal cancer risk. The results of the present study indicate that high cholesterol intake may increase colorectal cancer risk, but do not suggest the presence of significant effects of dietary fat intake on colorectal cancer incidence. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/11487265/Dietary_fat_cholesterol_and_colorectal_cancer_in_a_prospective_study_ L2 - http://dx.doi.org/10.1054/bjoc.2001.1906 DB - PRIME DP - Unbound Medicine ER -