Tags

Type your tag names separated by a space and hit enter

Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients.

Abstract

Acetaldehyde is a main factor of alcohol-induced asthma. We previously reported that the cysteinyl leukotriene (cys-LT) receptor antagonist, pranlukast hydrate, inhibits acetaldehyde-induced airway hyperresponsiveness in guinea pigs. The purpose of this study was to evaluate the involvement of cys-LT on bronchial responsiveness to acetaldehyde in asthmatic patients. We investigated the bronchial response to inhalation of acetaldehyde in 10 asthmatic patients, who were treated with placebo or pranlukast hydrate (225.5 mg), a cys-LT receptor antagonist, twice a day for 1 wk using a double-blind, randomized, placebo-controlled, cross-over design. Although a remarkable improvement of acetaldehyde bronchoconstriction was observed in 3 out of 10 subjects, PC(20)-AcCHO values were identical between placebo [12.0 (GSEM, 1.192) mg/ml] and pranlukast [14.7 (GSEM, 1.245) mg/ml] groups. The changes in bronchial responsiveness to acetaldehyde were similar in the six patients who had never experienced alcohol-induced asthma and the four who had. In conclusion, cys-LTs are not involved in acetaldehyde-induced bronchoconstriction.

Authors+Show Affiliations

The Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan. myous@nifty.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11487307

Citation

Myou, S, et al. "Effect of a Cysteinyl Leukotriene Antagonist, Pranlukast Hydrate, On Acetaldehyde-induced Bronchoconstriction in Asthmatic Patients." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 65, no. 1, 2001, pp. 41-4.
Myou S, Fujimura M, Kamio Y, et al. Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients. Prostaglandins Leukot Essent Fatty Acids. 2001;65(1):41-4.
Myou, S., Fujimura, M., Kamio, Y., Kita, T., Katayama, N., Abo, M., Yoshimi, Y., Nishitsuji, M., Nomura, S., Hashimoto, T., & Nakao, S. (2001). Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 65(1), 41-4.
Myou S, et al. Effect of a Cysteinyl Leukotriene Antagonist, Pranlukast Hydrate, On Acetaldehyde-induced Bronchoconstriction in Asthmatic Patients. Prostaglandins Leukot Essent Fatty Acids. 2001;65(1):41-4. PubMed PMID: 11487307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients. AU - Myou,S, AU - Fujimura,M, AU - Kamio,Y, AU - Kita,T, AU - Katayama,N, AU - Abo,M, AU - Yoshimi,Y, AU - Nishitsuji,M, AU - Nomura,S, AU - Hashimoto,T, AU - Nakao,S, PY - 2001/8/7/pubmed PY - 2001/10/5/medline PY - 2001/8/7/entrez SP - 41 EP - 4 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 65 IS - 1 N2 - Acetaldehyde is a main factor of alcohol-induced asthma. We previously reported that the cysteinyl leukotriene (cys-LT) receptor antagonist, pranlukast hydrate, inhibits acetaldehyde-induced airway hyperresponsiveness in guinea pigs. The purpose of this study was to evaluate the involvement of cys-LT on bronchial responsiveness to acetaldehyde in asthmatic patients. We investigated the bronchial response to inhalation of acetaldehyde in 10 asthmatic patients, who were treated with placebo or pranlukast hydrate (225.5 mg), a cys-LT receptor antagonist, twice a day for 1 wk using a double-blind, randomized, placebo-controlled, cross-over design. Although a remarkable improvement of acetaldehyde bronchoconstriction was observed in 3 out of 10 subjects, PC(20)-AcCHO values were identical between placebo [12.0 (GSEM, 1.192) mg/ml] and pranlukast [14.7 (GSEM, 1.245) mg/ml] groups. The changes in bronchial responsiveness to acetaldehyde were similar in the six patients who had never experienced alcohol-induced asthma and the four who had. In conclusion, cys-LTs are not involved in acetaldehyde-induced bronchoconstriction. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/11487307/Effect_of_a_cysteinyl_leukotriene_antagonist_pranlukast_hydrate_on_acetaldehyde_induced_bronchoconstriction_in_asthmatic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(01)90286-8 DB - PRIME DP - Unbound Medicine ER -