TY - JOUR T1 - Effect of a cysteinyl leukotriene antagonist, pranlukast hydrate, on acetaldehyde-induced bronchoconstriction in asthmatic patients. AU - Myou,S, AU - Fujimura,M, AU - Kamio,Y, AU - Kita,T, AU - Katayama,N, AU - Abo,M, AU - Yoshimi,Y, AU - Nishitsuji,M, AU - Nomura,S, AU - Hashimoto,T, AU - Nakao,S, PY - 2001/8/7/pubmed PY - 2001/10/5/medline PY - 2001/8/7/entrez SP - 41 EP - 4 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 65 IS - 1 N2 - Acetaldehyde is a main factor of alcohol-induced asthma. We previously reported that the cysteinyl leukotriene (cys-LT) receptor antagonist, pranlukast hydrate, inhibits acetaldehyde-induced airway hyperresponsiveness in guinea pigs. The purpose of this study was to evaluate the involvement of cys-LT on bronchial responsiveness to acetaldehyde in asthmatic patients. We investigated the bronchial response to inhalation of acetaldehyde in 10 asthmatic patients, who were treated with placebo or pranlukast hydrate (225.5 mg), a cys-LT receptor antagonist, twice a day for 1 wk using a double-blind, randomized, placebo-controlled, cross-over design. Although a remarkable improvement of acetaldehyde bronchoconstriction was observed in 3 out of 10 subjects, PC(20)-AcCHO values were identical between placebo [12.0 (GSEM, 1.192) mg/ml] and pranlukast [14.7 (GSEM, 1.245) mg/ml] groups. The changes in bronchial responsiveness to acetaldehyde were similar in the six patients who had never experienced alcohol-induced asthma and the four who had. In conclusion, cys-LTs are not involved in acetaldehyde-induced bronchoconstriction. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/11487307/Effect_of_a_cysteinyl_leukotriene_antagonist_pranlukast_hydrate_on_acetaldehyde_induced_bronchoconstriction_in_asthmatic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(01)90286-8 DB - PRIME DP - Unbound Medicine ER -