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Adult survival after prenatal exposure to the Dutch famine 1944--45.

Abstract

Early life events may affect adult survival. We studied the effect of prenatal exposure to the Dutch famine 1944--45 on survival among 2254 people born in Amsterdam. Mortality up to age 50 was highest among those born before the famine (15.2%) and among those exposed to famine in late gestation (14.6%). It was lower among those exposed in mid- (11.2%) or early gestation (11.5%), and was lowest among those conceived after the famine (7.2%). These differences were caused by effects on mortality in the first year after birth and were mainly related to nutrition and infections. There was no effect of exposure to famine on mortality after the age of 18. The hazard ratio was 1.4 [0.8, 2.3] for those born before the famine, 1.1 [0.5, 2.3] for those exposed in late gestation, 0.8 [0.3, 1.8] for those exposed in mid-gestation and 1.1 [0.5, 2.5] in those exposed in early gestation compared with those conceived after the famine. We could not demonstrate effects of prenatal exposure to famine on cause-specific mortality after the age of 18. Because prenatal exposure to famine is linked to cardiovascular risk factors and disease, increased cardiovascular mortality in the future may be expected.

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  • Authors+Show Affiliations

    ,

    Department of Clinical Epidemiology, Academic Medical Centre, Amsterdam, The Netherlands. t.j.roseboom@amc.uva.nl

    , , , ,

    Source

    MeSH

    Adult
    Age Factors
    Cohort Studies
    Female
    Humans
    Male
    Middle Aged
    Netherlands
    Nutrition Disorders
    Pregnancy
    Prenatal Exposure Delayed Effects
    Starvation

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11489148

    Citation

    Roseboom, T J., et al. "Adult Survival After Prenatal Exposure to the Dutch Famine 1944--45." Paediatric and Perinatal Epidemiology, vol. 15, no. 3, 2001, pp. 220-5.
    Roseboom TJ, van der Meulen JH, Osmond C, et al. Adult survival after prenatal exposure to the Dutch famine 1944--45. Paediatr Perinat Epidemiol. 2001;15(3):220-5.
    Roseboom, T. J., van der Meulen, J. H., Osmond, C., Barker, D. J., Ravelli, A. C., & Bleker, O. P. (2001). Adult survival after prenatal exposure to the Dutch famine 1944--45. Paediatric and Perinatal Epidemiology, 15(3), pp. 220-5.
    Roseboom TJ, et al. Adult Survival After Prenatal Exposure to the Dutch Famine 1944--45. Paediatr Perinat Epidemiol. 2001;15(3):220-5. PubMed PMID: 11489148.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adult survival after prenatal exposure to the Dutch famine 1944--45. AU - Roseboom,T J, AU - van der Meulen,J H, AU - Osmond,C, AU - Barker,D J, AU - Ravelli,A C, AU - Bleker,O P, PY - 2001/8/8/pubmed PY - 2001/9/28/medline PY - 2001/8/8/entrez SP - 220 EP - 5 JF - Paediatric and perinatal epidemiology JO - Paediatr Perinat Epidemiol VL - 15 IS - 3 N2 - Early life events may affect adult survival. We studied the effect of prenatal exposure to the Dutch famine 1944--45 on survival among 2254 people born in Amsterdam. Mortality up to age 50 was highest among those born before the famine (15.2%) and among those exposed to famine in late gestation (14.6%). It was lower among those exposed in mid- (11.2%) or early gestation (11.5%), and was lowest among those conceived after the famine (7.2%). These differences were caused by effects on mortality in the first year after birth and were mainly related to nutrition and infections. There was no effect of exposure to famine on mortality after the age of 18. The hazard ratio was 1.4 [0.8, 2.3] for those born before the famine, 1.1 [0.5, 2.3] for those exposed in late gestation, 0.8 [0.3, 1.8] for those exposed in mid-gestation and 1.1 [0.5, 2.5] in those exposed in early gestation compared with those conceived after the famine. We could not demonstrate effects of prenatal exposure to famine on cause-specific mortality after the age of 18. Because prenatal exposure to famine is linked to cardiovascular risk factors and disease, increased cardiovascular mortality in the future may be expected. SN - 0269-5022 UR - https://www.unboundmedicine.com/medline/citation/11489148/Adult_survival_after_prenatal_exposure_to_the_Dutch_famine_1944__45_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-5022&date=2001&volume=15&issue=3&spage=220 DB - PRIME DP - Unbound Medicine ER -