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The effect of tranexamic acid on cochlear blood flow in guinea pigs measured by laser Doppler flowmetry.
Auris Nasus Larynx. 2001 Aug; 28(3):215-8.AN

Abstract

OBJECTIVE

This study investigated the vasoactive effect of tranexamic acid on the cochlear blood flow in guinea pigs.

METHOD

3 ml solution (infusion speed, 0.5 ml/min) containing different concentrations of tranexamic acid was intravenously infused into 15 guinea pigs under general anesthesia. The guinea pigs were grouped according to four levels of dosage of the medicine (470 mg/kg, n=6; 220 mg/kg, n=3; 4 mg/kg, n=3; 1 mg/kg, n=3). Before administering medicine, saline solution was administered in similar volume and speed as a control. The cochleas were surgically exposed and laser Doppler flowmetry monitored cochlear blood flow volume (CBF). The left femoral artery was cannulated to permit a transducer to monitor systemic blood pressure (BP).

RESULTS

(1) Stimulatory effect of tranexamic acid on CBF was dose-dependent at concentrations of 1-470 mg/kg and, (2) the time course of changes in CBF was almost identical to that in BP following tranexamic acid administration.

CONCLUSION

Preliminary findings suggest that intravenous administration of tranexamic acid increases CBF due to vasomotorial mechanism effect on BP.

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Authors+Show Affiliations

Tran YH
Division of Clinical Otology, Tokushima University Hospital, Tokushima 770-8503, Japan.
Ohsaki K
No affiliation info available
Houchi H
No affiliation info available
Ogawa T
No affiliation info available
Zhu CS
No affiliation info available
Fushitani S
No affiliation info available
Minakuchi K
No affiliation info available

MeSH

AnimalsBlood PressureCochleaDose-Response Relationship, DrugGuinea PigsInfusions, IntravenousLaser-Doppler FlowmetryMaleTranexamic AcidVasodilator Agents

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11489363

Citation

Tran, Y H., et al. "The Effect of Tranexamic Acid On Cochlear Blood Flow in Guinea Pigs Measured By Laser Doppler Flowmetry." Auris, Nasus, Larynx, vol. 28, no. 3, 2001, pp. 215-8.
Tran YH, Ohsaki K, Houchi H, et al. The effect of tranexamic acid on cochlear blood flow in guinea pigs measured by laser Doppler flowmetry. Auris Nasus Larynx. 2001;28(3):215-8.
Tran, Y. H., Ohsaki, K., Houchi, H., Ogawa, T., Zhu, C. S., Fushitani, S., & Minakuchi, K. (2001). The effect of tranexamic acid on cochlear blood flow in guinea pigs measured by laser Doppler flowmetry. Auris, Nasus, Larynx, 28(3), 215-8.
Tran YH, et al. The Effect of Tranexamic Acid On Cochlear Blood Flow in Guinea Pigs Measured By Laser Doppler Flowmetry. Auris Nasus Larynx. 2001;28(3):215-8. PubMed PMID: 11489363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of tranexamic acid on cochlear blood flow in guinea pigs measured by laser Doppler flowmetry. AU - Tran,Y H, AU - Ohsaki,K, AU - Houchi,H, AU - Ogawa,T, AU - Zhu,C S, AU - Fushitani,S, AU - Minakuchi,K, PY - 2001/8/8/pubmed PY - 2002/1/5/medline PY - 2001/8/8/entrez SP - 215 EP - 8 JF - Auris, nasus, larynx JO - Auris Nasus Larynx VL - 28 IS - 3 N2 - OBJECTIVE: This study investigated the vasoactive effect of tranexamic acid on the cochlear blood flow in guinea pigs. METHOD: 3 ml solution (infusion speed, 0.5 ml/min) containing different concentrations of tranexamic acid was intravenously infused into 15 guinea pigs under general anesthesia. The guinea pigs were grouped according to four levels of dosage of the medicine (470 mg/kg, n=6; 220 mg/kg, n=3; 4 mg/kg, n=3; 1 mg/kg, n=3). Before administering medicine, saline solution was administered in similar volume and speed as a control. The cochleas were surgically exposed and laser Doppler flowmetry monitored cochlear blood flow volume (CBF). The left femoral artery was cannulated to permit a transducer to monitor systemic blood pressure (BP). RESULTS: (1) Stimulatory effect of tranexamic acid on CBF was dose-dependent at concentrations of 1-470 mg/kg and, (2) the time course of changes in CBF was almost identical to that in BP following tranexamic acid administration. CONCLUSION: Preliminary findings suggest that intravenous administration of tranexamic acid increases CBF due to vasomotorial mechanism effect on BP. SN - 0385-8146 UR - https://www.unboundmedicine.com/medline/citation/11489363/The_effect_of_tranexamic_acid_on_cochlear_blood_flow_in_guinea_pigs_measured_by_laser_Doppler_flowmetry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0385814601000505 DB - PRIME DP - Unbound Medicine ER -