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Antibodies to Ro and La.
Ann Med Interne (Paris). 1998 Feb; 149(1):34-41.AM

Abstract

Precipitating antibodies to Ro and La occur in a subset of patients with systemic lupus erythematosus (SLE) constituting just under 50 and 20% respectively of the total spectrum. These precipitating autoantibodies are even more prevalent in primary Sjögren's syndrome (SS) occurring in 60-80% (anti-Ro) and 40-60% (anti-La) of that disease. Patients with an overlap of SLE and SS virtually all possess both anti-Ro and anti-La. These autoantibodies appear years before the appearance of clinical disease as evidenced by the behavior of women who possess them and herald this presence by having children born with the manifestations of neonatal lupus, principally a characteristic lupus dermatitis or complete congenital heart block. The close association of several clinical manifestations involving the skin, lung, and blood elements suggests a pathogenic role for these autoantibodies in disease expression. The elucidation of these relationships should greatly improve our understanding of the etiopathogenesis of both SLE and SS.

Authors+Show Affiliations

Immunology Section, Oklahoma University Health Sciences Center, OK, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

11490515

Citation

Reichlin, M. "Antibodies to Ro and La." Annales De Medecine Interne, vol. 149, no. 1, 1998, pp. 34-41.
Reichlin M. Antibodies to Ro and La. Ann Med Interne (Paris). 1998;149(1):34-41.
Reichlin, M. (1998). Antibodies to Ro and La. Annales De Medecine Interne, 149(1), 34-41.
Reichlin M. Antibodies to Ro and La. Ann Med Interne (Paris). 1998;149(1):34-41. PubMed PMID: 11490515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibodies to Ro and La. A1 - Reichlin,M, PY - 2001/8/9/pubmed PY - 2001/9/21/medline PY - 2001/8/9/entrez SP - 34 EP - 41 JF - Annales de medecine interne JO - Ann Med Interne (Paris) VL - 149 IS - 1 N2 - Precipitating antibodies to Ro and La occur in a subset of patients with systemic lupus erythematosus (SLE) constituting just under 50 and 20% respectively of the total spectrum. These precipitating autoantibodies are even more prevalent in primary Sjögren's syndrome (SS) occurring in 60-80% (anti-Ro) and 40-60% (anti-La) of that disease. Patients with an overlap of SLE and SS virtually all possess both anti-Ro and anti-La. These autoantibodies appear years before the appearance of clinical disease as evidenced by the behavior of women who possess them and herald this presence by having children born with the manifestations of neonatal lupus, principally a characteristic lupus dermatitis or complete congenital heart block. The close association of several clinical manifestations involving the skin, lung, and blood elements suggests a pathogenic role for these autoantibodies in disease expression. The elucidation of these relationships should greatly improve our understanding of the etiopathogenesis of both SLE and SS. SN - 0003-410X UR - https://www.unboundmedicine.com/medline/citation/11490515/Antibodies_to_Ro_and_La_ L2 - https://medlineplus.gov/sjogrenssyndrome.html DB - PRIME DP - Unbound Medicine ER -