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Hepatic resection for intrahepatic cholangiocarcinoma: relation to gross tumor morphology.
Hepatogastroenterology. 2001 Jul-Aug; 48(40):1129-33.H

Abstract

BACKGROUND/AIMS

The aim of this study was to investigate the clinicopathologic features and biological behaviors related to the gross appearance of intrahepatic cholangiocarcinoma.

METHODOLOGY

Fourteen patients with intrahepatic cholangiocarcinoma who underwent hepatic resection between 1986 and 1998 were divided into four groups according to the gross appearance of the tumor: ID (intraductal growth) type (n = 1), PD (periductal-infiltrating) type (n = 4), MF (mass-forming) type (n = 5), MF-with-PD type (n = 4).

RESULTS

Overall survival at 1, 5, and 10 years was 50.0%, 35.7%, and 35.7%, respectively. All three long-term survivors without recurrence had tumors unassociated with vascular invasion, intrahepatic metastasis, or lymph node metastasis. The MF and MF-with-PD tumors were more frequently associated with vascular invasion and/or lymph node metastasis than the ID or PD type. The Ki-67-positive grade of the cancer cells was clearly higher in the MF and MF-with-PD tumors than in the ID or PD type. All of the cases of MF-with-PD tumors were stage IV-A and had a poor outcome.

CONCLUSIONS

Extended hepatic resection with a sufficient surgical margin yielded good results in intrahepatic cholangiocarcinoma patients without vascular invasion, intrahepatic metastasis, or lymph node metastasis. However, it is necessary to develop a new effective strategy for advanced intrahepatic cholangiocarcinomas, such as the MF-with-PD type.

Authors+Show Affiliations

Department of Surgery II, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-Ku, Hiroshima, Japan. titamoto@mcai.med.hiroshima-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11490816

Citation

Itamoto, T, et al. "Hepatic Resection for Intrahepatic Cholangiocarcinoma: Relation to Gross Tumor Morphology." Hepato-gastroenterology, vol. 48, no. 40, 2001, pp. 1129-33.
Itamoto T, Asahara T, Katayama K, et al. Hepatic resection for intrahepatic cholangiocarcinoma: relation to gross tumor morphology. Hepatogastroenterology. 2001;48(40):1129-33.
Itamoto, T., Asahara, T., Katayama, K., Nakahara, H., Fukuda, T., Yano, M., Hino, H., Nakahara, M., Dohi, K., & Shimamoto, F. (2001). Hepatic resection for intrahepatic cholangiocarcinoma: relation to gross tumor morphology. Hepato-gastroenterology, 48(40), 1129-33.
Itamoto T, et al. Hepatic Resection for Intrahepatic Cholangiocarcinoma: Relation to Gross Tumor Morphology. Hepatogastroenterology. 2001 Jul-Aug;48(40):1129-33. PubMed PMID: 11490816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatic resection for intrahepatic cholangiocarcinoma: relation to gross tumor morphology. AU - Itamoto,T, AU - Asahara,T, AU - Katayama,K, AU - Nakahara,H, AU - Fukuda,T, AU - Yano,M, AU - Hino,H, AU - Nakahara,M, AU - Dohi,K, AU - Shimamoto,F, PY - 2001/8/9/pubmed PY - 2002/1/5/medline PY - 2001/8/9/entrez SP - 1129 EP - 33 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 48 IS - 40 N2 - BACKGROUND/AIMS: The aim of this study was to investigate the clinicopathologic features and biological behaviors related to the gross appearance of intrahepatic cholangiocarcinoma. METHODOLOGY: Fourteen patients with intrahepatic cholangiocarcinoma who underwent hepatic resection between 1986 and 1998 were divided into four groups according to the gross appearance of the tumor: ID (intraductal growth) type (n = 1), PD (periductal-infiltrating) type (n = 4), MF (mass-forming) type (n = 5), MF-with-PD type (n = 4). RESULTS: Overall survival at 1, 5, and 10 years was 50.0%, 35.7%, and 35.7%, respectively. All three long-term survivors without recurrence had tumors unassociated with vascular invasion, intrahepatic metastasis, or lymph node metastasis. The MF and MF-with-PD tumors were more frequently associated with vascular invasion and/or lymph node metastasis than the ID or PD type. The Ki-67-positive grade of the cancer cells was clearly higher in the MF and MF-with-PD tumors than in the ID or PD type. All of the cases of MF-with-PD tumors were stage IV-A and had a poor outcome. CONCLUSIONS: Extended hepatic resection with a sufficient surgical margin yielded good results in intrahepatic cholangiocarcinoma patients without vascular invasion, intrahepatic metastasis, or lymph node metastasis. However, it is necessary to develop a new effective strategy for advanced intrahepatic cholangiocarcinomas, such as the MF-with-PD type. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/11490816/Hepatic_resection_for_intrahepatic_cholangiocarcinoma:_relation_to_gross_tumor_morphology_ L2 - http://www.diseaseinfosearch.org/result/3854 DB - PRIME DP - Unbound Medicine ER -