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Autoantibodies against oxidized low density lipoproteins in patients with stable angina, unstable angina or peripheral vascular disease; pathophysiological implications.
Eur Heart J. 2001 Sep; 22(17):1572-7.EH

Abstract

BACKGROUND

Antibody antioxidized low density lipoproteins (oxLDL) might play a role both in atherogenesis and in the pathogenesis of acute coronary syndromes.

METHODS AND RESULTS

Antibody titres to oxLDL and levels of C-reactive protein were compared in unstable angina, stable angina or peripheral artery disease. Antibody titres to LDL oxidated by CuSO(4)for 2, 4 and 18 h (Cu-oxLDL-Ab(2-4-18)) or by peroxidase (HRP-oxLDL-Ab) were assessed by ELISA. Cu-oxLDL-Ab(2-4-18)were consistently higher in peripheral artery disease than in unstable angina (P<0.001, P<0.001, P=0.01, respectively) or in stable angina (P<0.001, P=0.01, P=ns) but similar in unstable and stable angina. Accordingly, HRP-oxLDL-Ab were higher in peripheral artery disease than in unstable angina (P<0.001) or stable angina (P=0.04) but similar in unstable and stable angina. The number of arterial stenoses was higher in peripheral artery disease than unstable and stable angina (P<0.01). Cu-oxLDL-Ab and HRP-oxLDL-Ab correlated with the severity of atherosclerosis (P<0.01, R=0.4;P=0.02, R=0.3 respectively). Conversely, C-reactive protein levels were higher in unstable than in stable angina (P<0.001) or in peripheral artery disease (P<0.03) but similar in stable angina and peripheral artery disease and did not correlate with the severity of atherosclerosis.

CONCLUSION

The autoimmune response to oxLDL is likely to play an important role in atherogenesis but not in precipitating acute coronary syndromes.

Authors+Show Affiliations

Istituto di Cardiologia, Università Cattolica del Sacro Cuore, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11492986

Citation

Monaco, C, et al. "Autoantibodies Against Oxidized Low Density Lipoproteins in Patients With Stable Angina, Unstable Angina or Peripheral Vascular Disease; Pathophysiological Implications." European Heart Journal, vol. 22, no. 17, 2001, pp. 1572-7.
Monaco C, Crea F, Niccoli G, et al. Autoantibodies against oxidized low density lipoproteins in patients with stable angina, unstable angina or peripheral vascular disease; pathophysiological implications. Eur Heart J. 2001;22(17):1572-7.
Monaco, C., Crea, F., Niccoli, G., Summaria, F., Cianflone, D., Bordone, R., Bellomo, G., & Maseri, A. (2001). Autoantibodies against oxidized low density lipoproteins in patients with stable angina, unstable angina or peripheral vascular disease; pathophysiological implications. European Heart Journal, 22(17), 1572-7.
Monaco C, et al. Autoantibodies Against Oxidized Low Density Lipoproteins in Patients With Stable Angina, Unstable Angina or Peripheral Vascular Disease; Pathophysiological Implications. Eur Heart J. 2001;22(17):1572-7. PubMed PMID: 11492986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoantibodies against oxidized low density lipoproteins in patients with stable angina, unstable angina or peripheral vascular disease; pathophysiological implications. AU - Monaco,C, AU - Crea,F, AU - Niccoli,G, AU - Summaria,F, AU - Cianflone,D, AU - Bordone,R, AU - Bellomo,G, AU - Maseri,A, PY - 2001/8/9/pubmed PY - 2001/9/21/medline PY - 2001/8/9/entrez SP - 1572 EP - 7 JF - European heart journal JO - Eur Heart J VL - 22 IS - 17 N2 - BACKGROUND: Antibody antioxidized low density lipoproteins (oxLDL) might play a role both in atherogenesis and in the pathogenesis of acute coronary syndromes. METHODS AND RESULTS: Antibody titres to oxLDL and levels of C-reactive protein were compared in unstable angina, stable angina or peripheral artery disease. Antibody titres to LDL oxidated by CuSO(4)for 2, 4 and 18 h (Cu-oxLDL-Ab(2-4-18)) or by peroxidase (HRP-oxLDL-Ab) were assessed by ELISA. Cu-oxLDL-Ab(2-4-18)were consistently higher in peripheral artery disease than in unstable angina (P<0.001, P<0.001, P=0.01, respectively) or in stable angina (P<0.001, P=0.01, P=ns) but similar in unstable and stable angina. Accordingly, HRP-oxLDL-Ab were higher in peripheral artery disease than in unstable angina (P<0.001) or stable angina (P=0.04) but similar in unstable and stable angina. The number of arterial stenoses was higher in peripheral artery disease than unstable and stable angina (P<0.01). Cu-oxLDL-Ab and HRP-oxLDL-Ab correlated with the severity of atherosclerosis (P<0.01, R=0.4;P=0.02, R=0.3 respectively). Conversely, C-reactive protein levels were higher in unstable than in stable angina (P<0.001) or in peripheral artery disease (P<0.03) but similar in stable angina and peripheral artery disease and did not correlate with the severity of atherosclerosis. CONCLUSION: The autoimmune response to oxLDL is likely to play an important role in atherogenesis but not in precipitating acute coronary syndromes. SN - 0195-668X UR - https://www.unboundmedicine.com/medline/citation/11492986/Autoantibodies_against_oxidized_low_density_lipoproteins_in_patients_with_stable_angina_unstable_angina_or_peripheral_vascular_disease L2 - https://academic.oup.com/eurheartj/article-lookup/doi/10.1053/euhj.2000.2554 DB - PRIME DP - Unbound Medicine ER -