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Primary pulmonary hypertension in pregnancy; a role for novel vasodilators.
Br J Anaesth. 2001 Aug; 87(2):295-8.BJ

Abstract

We describe the case of a 28-week pregnant woman presenting with severe primary pulmonary hypertension (PPH). She had an elective Caesarean section under general anaesthesia at 32 weeks gestation. Pulmonary artery pressures (PAP) measured from a pulmonary artery catheter before anaesthesia were in excess of 100 mm Hg. Intraoperative nitric oxide was used to reduce PAP. After the delivery of a healthy infant PAP was controlled with nebulized iloprost and a prostacyclin infusion. Seven days later she was discharged from intensive care taking an oral calcium antagonist and warfarin. She developed intractable right heart failure and died 14 days after delivery. Despite increasing experience in the use of drugs to reduce PAP, the clinical course of pregnancy complicated by severe PPH is usually fatal.

Authors+Show Affiliations

Department of Anaesthesia, Dorset County Hospital, Williams Avenue, Dorchester DT1 2JY, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11493507

Citation

Monnery, L, et al. "Primary Pulmonary Hypertension in Pregnancy; a Role for Novel Vasodilators." British Journal of Anaesthesia, vol. 87, no. 2, 2001, pp. 295-8.
Monnery L, Nanson J, Charlton G. Primary pulmonary hypertension in pregnancy; a role for novel vasodilators. Br J Anaesth. 2001;87(2):295-8.
Monnery, L., Nanson, J., & Charlton, G. (2001). Primary pulmonary hypertension in pregnancy; a role for novel vasodilators. British Journal of Anaesthesia, 87(2), 295-8.
Monnery L, Nanson J, Charlton G. Primary Pulmonary Hypertension in Pregnancy; a Role for Novel Vasodilators. Br J Anaesth. 2001;87(2):295-8. PubMed PMID: 11493507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary pulmonary hypertension in pregnancy; a role for novel vasodilators. AU - Monnery,L, AU - Nanson,J, AU - Charlton,G, PY - 2001/8/9/pubmed PY - 2002/1/10/medline PY - 2001/8/9/entrez SP - 295 EP - 8 JF - British journal of anaesthesia JO - Br J Anaesth VL - 87 IS - 2 N2 - We describe the case of a 28-week pregnant woman presenting with severe primary pulmonary hypertension (PPH). She had an elective Caesarean section under general anaesthesia at 32 weeks gestation. Pulmonary artery pressures (PAP) measured from a pulmonary artery catheter before anaesthesia were in excess of 100 mm Hg. Intraoperative nitric oxide was used to reduce PAP. After the delivery of a healthy infant PAP was controlled with nebulized iloprost and a prostacyclin infusion. Seven days later she was discharged from intensive care taking an oral calcium antagonist and warfarin. She developed intractable right heart failure and died 14 days after delivery. Despite increasing experience in the use of drugs to reduce PAP, the clinical course of pregnancy complicated by severe PPH is usually fatal. SN - 0007-0912 UR - https://www.unboundmedicine.com/medline/citation/11493507/Primary_pulmonary_hypertension_in_pregnancy L2 - https://linkinghub.elsevier.com/retrieve/pii/S0007-0912(17)37640-7 DB - PRIME DP - Unbound Medicine ER -