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Patterning of fast and slow fibers within embryonic muscles is established independently of signals from the surrounding mesenchyme.
Development. 2001 Jul; 128(13):2537-44.D

Abstract

During embryonic development, and before functional innervation, a highly stereotypic pattern of slow- and fast-contracting primary muscle fibers is established within individual muscles of the limbs, from distinct populations of myoblasts. A difference between the fiber-type pattern found within chicken and quail pectoral muscles was exploited to investigate the contributions of somite-derived myogenic precursors and lateral plate-derived mesenchymal stroma to the establishment of muscle fiber-type patterns. Chimeric chicken/quail embryos were constructed by reciprocal transplantation of somites or lateral plate mesoderm at stages prior to muscle formation. Muscle fibers derived from quail myogenic precursors that had migrated into chicken stroma showed a quail pattern of mixed fast- and slow-contracting muscle fibers. Conversely, chicken myogenic precursors that had migrated into quail stroma showed a chicken pattern of nearly exclusive fast muscle fiber formation. These results demonstrate in vivo an intrinsic commitment to fiber-type on the part of the myoblast, independent of extrinsic signals it receives from the mesenchymal stroma in which it differentiates.

Authors+Show Affiliations

Department of Medicine, Stanford University School of Medicine, Stanford, California 94305-5151, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

11493570

Citation

Nikovits, W, et al. "Patterning of Fast and Slow Fibers Within Embryonic Muscles Is Established Independently of Signals From the Surrounding Mesenchyme." Development (Cambridge, England), vol. 128, no. 13, 2001, pp. 2537-44.
Nikovits W, Cann GM, Huang R, et al. Patterning of fast and slow fibers within embryonic muscles is established independently of signals from the surrounding mesenchyme. Development. 2001;128(13):2537-44.
Nikovits, W., Cann, G. M., Huang, R., Christ, B., & Stockdale, F. E. (2001). Patterning of fast and slow fibers within embryonic muscles is established independently of signals from the surrounding mesenchyme. Development (Cambridge, England), 128(13), 2537-44.
Nikovits W, et al. Patterning of Fast and Slow Fibers Within Embryonic Muscles Is Established Independently of Signals From the Surrounding Mesenchyme. Development. 2001;128(13):2537-44. PubMed PMID: 11493570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patterning of fast and slow fibers within embryonic muscles is established independently of signals from the surrounding mesenchyme. AU - Nikovits,W,Jr AU - Cann,G M, AU - Huang,R, AU - Christ,B, AU - Stockdale,F E, PY - 2001/8/9/pubmed PY - 2001/9/8/medline PY - 2001/8/9/entrez SP - 2537 EP - 44 JF - Development (Cambridge, England) JO - Development VL - 128 IS - 13 N2 - During embryonic development, and before functional innervation, a highly stereotypic pattern of slow- and fast-contracting primary muscle fibers is established within individual muscles of the limbs, from distinct populations of myoblasts. A difference between the fiber-type pattern found within chicken and quail pectoral muscles was exploited to investigate the contributions of somite-derived myogenic precursors and lateral plate-derived mesenchymal stroma to the establishment of muscle fiber-type patterns. Chimeric chicken/quail embryos were constructed by reciprocal transplantation of somites or lateral plate mesoderm at stages prior to muscle formation. Muscle fibers derived from quail myogenic precursors that had migrated into chicken stroma showed a quail pattern of mixed fast- and slow-contracting muscle fibers. Conversely, chicken myogenic precursors that had migrated into quail stroma showed a chicken pattern of nearly exclusive fast muscle fiber formation. These results demonstrate in vivo an intrinsic commitment to fiber-type on the part of the myoblast, independent of extrinsic signals it receives from the mesenchymal stroma in which it differentiates. SN - 0950-1991 UR - https://www.unboundmedicine.com/medline/citation/11493570/Patterning_of_fast_and_slow_fibers_within_embryonic_muscles_is_established_independently_of_signals_from_the_surrounding_mesenchyme_ L2 - https://journals.biologists.com/dev/article-lookup/doi/10.1242/dev.128.13.2537 DB - PRIME DP - Unbound Medicine ER -