TY - JOUR T1 - Natural development of antibodies to pneumococcal capsular polysaccharides depends on the serotype: association with pneumococcal carriage and acute otitis media in young children. AU - Soininen,A, AU - Pursiainen,H, AU - Kilpi,T, AU - Käyhty,H, Y1 - 2001/08/02/ PY - 2000/12/11/received PY - 2001/05/10/revised PY - 2001/8/9/pubmed PY - 2001/9/21/medline PY - 2001/8/9/entrez SP - 569 EP - 76 JF - The Journal of infectious diseases JO - J Infect Dis VL - 184 IS - 5 N2 - To study the natural development of antibodies to pneumococcal capsular polysaccharides of types 1, 6B, 11A, 14, 19F, and 23F and its association with pneumococcal carriage and acute otitis media (AOM), 329 children were followed-up prospectively during their first 2 years of life. Nasopharyngeal carriage was determined by cultures of nasopharyngeal swab samples, and etiology of AOM was determined by cultures of middle ear fluid. Antibodies were measured in serum samples collected at 6, 12, 18, and 24 months by EIA. Antibodies increased modestly but significantly with age. Contact with serotypes 11A and 14 was associated with increased antibody concentration as early as age 6 months. Children with contact with serotypes 6B, 19F, and 23F had antibody levels similar to those in children without contact. Antibodies increased modestly, even in children without known contact with Streptococcus pneumoniae and in children with contact with heterologous serotypes. Antibody concentrations were equal after carriage or AOM. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/11494163/Natural_development_of_antibodies_to_pneumococcal_capsular_polysaccharides_depends_on_the_serotype:_association_with_pneumococcal_carriage_and_acute_otitis_media_in_young_children_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/322794 DB - PRIME DP - Unbound Medicine ER -