Tags

Type your tag names separated by a space and hit enter

Is epsilon4 allele of apolipoprotein E associated with more severe end-organ damage in essential hypertension?
Cell Biochem Funct. 2001 Sep; 19(3):191-5.CB

Abstract

The aim of the present study comparing patients with mild to moderate hypertension with controls, was to explore a possible association between hypertension-related target organ damage and evaluation found in the gene encoding apolipoprotein E (apo E) genotype. Detailed medical history was recorded and physical examination was performed for all patients in the study (88 hypertensives, 63 normotensive controls). PCR (Polymerase Chain Reaction), RFLP (Restriction Fragment Length Polymorphism), and agarose gel electrophoresis techniques were used to determine the apo E genotypes. The frequencies of apo epsilon2, apo epsilon3, and apo epsilon4 alleles were 3.97, 88.06, and 9.95%, respectively in the hypertensive group. The frequencies of apo epsilon2, apo epsilon3, and apo epsilon4 alleles were 5.5, 92.0, and 2.38%, respectively in the control group. There were about twice as many individuals in the heterozygote hypertensive group who had apo E3/4 as compared to the control group (7.30 vs. 2.38%) (p = 0.07). The hypertensive patients who were carriers of the apo epsilon4 had significantly higher organ damage (left ventricular hypertrophy (p < 0.001). dilated left atrium (p < 0.05), retinopathy (p < 0.05)) as compared to those who were not carriers of apo epsilon4. These results showed a trend for the epsilon4 allele to be associated with a higher prevalence of target organ damage in patients with mild to moderate hypertension.

Authors+Show Affiliations

Yilmaz H
Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey.
Isbir T
No affiliation info available
Ağaçhan B
No affiliation info available
Aydin M
No affiliation info available

MeSH

AdultAllelesApolipoproteins EBlood PressureFemaleGene FrequencyGenotypeHeterozygoteHomozygoteHumansHypertensionHypertrophy, Left VentricularMaleMiddle AgedMyocardiumPolymerase Chain ReactionPolymorphism, GeneticRetina

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11494308

Citation

Yilmaz, H, et al. "Is Epsilon4 Allele of Apolipoprotein E Associated With More Severe End-organ Damage in Essential Hypertension?" Cell Biochemistry and Function, vol. 19, no. 3, 2001, pp. 191-5.
Yilmaz H, Isbir T, Ağaçhan B, et al. Is epsilon4 allele of apolipoprotein E associated with more severe end-organ damage in essential hypertension? Cell Biochem Funct. 2001;19(3):191-5.
Yilmaz, H., Isbir, T., Ağaçhan, B., & Aydin, M. (2001). Is epsilon4 allele of apolipoprotein E associated with more severe end-organ damage in essential hypertension? Cell Biochemistry and Function, 19(3), 191-5.
Yilmaz H, et al. Is Epsilon4 Allele of Apolipoprotein E Associated With More Severe End-organ Damage in Essential Hypertension. Cell Biochem Funct. 2001;19(3):191-5. PubMed PMID: 11494308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is epsilon4 allele of apolipoprotein E associated with more severe end-organ damage in essential hypertension? AU - Yilmaz,H, AU - Isbir,T, AU - Ağaçhan,B, AU - Aydin,M, PY - 2001/8/9/pubmed PY - 2001/10/5/medline PY - 2001/8/9/entrez SP - 191 EP - 5 JF - Cell biochemistry and function JO - Cell Biochem Funct VL - 19 IS - 3 N2 - The aim of the present study comparing patients with mild to moderate hypertension with controls, was to explore a possible association between hypertension-related target organ damage and evaluation found in the gene encoding apolipoprotein E (apo E) genotype. Detailed medical history was recorded and physical examination was performed for all patients in the study (88 hypertensives, 63 normotensive controls). PCR (Polymerase Chain Reaction), RFLP (Restriction Fragment Length Polymorphism), and agarose gel electrophoresis techniques were used to determine the apo E genotypes. The frequencies of apo epsilon2, apo epsilon3, and apo epsilon4 alleles were 3.97, 88.06, and 9.95%, respectively in the hypertensive group. The frequencies of apo epsilon2, apo epsilon3, and apo epsilon4 alleles were 5.5, 92.0, and 2.38%, respectively in the control group. There were about twice as many individuals in the heterozygote hypertensive group who had apo E3/4 as compared to the control group (7.30 vs. 2.38%) (p = 0.07). The hypertensive patients who were carriers of the apo epsilon4 had significantly higher organ damage (left ventricular hypertrophy (p < 0.001). dilated left atrium (p < 0.05), retinopathy (p < 0.05)) as compared to those who were not carriers of apo epsilon4. These results showed a trend for the epsilon4 allele to be associated with a higher prevalence of target organ damage in patients with mild to moderate hypertension. SN - 0263-6484 UR - https://www.unboundmedicine.com/medline/citation/11494308/Is_epsilon4_allele_of_apolipoprotein_E_associated_with_more_severe_end_organ_damage_in_essential_hypertension L2 - https://doi.org/10.1002/cbf.915 DB - PRIME DP - Unbound Medicine ER -