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Polymorphic repeats in the androgen receptor gene in high-risk sibships.
Prostate. 2001 Aug 01; 48(3):200-5.P

Abstract

BACKGROUND

Genetic susceptibility may explain some familial clusters of prostate cancer. The polymorphic androgen receptor (AR) gene, which mediates androgen activity in the prostate, is a candidate gene that may influence predisposition to the disease.

METHODS

We analyzed the polymorphic (CAG)n and (GGN)n repeats within the AR gene in men from 51 high-risk prostate cancer sibships, which included at least one affected and one unaffected man (n = 210). We compared repeat lengths of men with prostate cancer (n = 140) to their brothers (n = 70) without disease, stratified by median age at diagnosis of affected men within each sibship. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals to evaluate associations between prostate cancer and repeat length.

RESULTS

The OR for prostate cancer associated with short (CAG)n repeats (< 22) compared to longer repeats (> or =22) was 1.13 (95% CI 0.5-2.4) overall, but was higher in sibships with a median age of <66 years at diagnosis (OR = 1.72, 95% CI 0.5-6.0). The (GGN)n array also was not associated with prostate cancer in general. However, in older men (> or = 66 years), there was a modest elevation in risk (OR = 1.56, 95% CI 0.6-4.1) among those with short repeats (GGN of < or =16). Men with both a short (CAG)n (< 22) and a short (GGN)n (< or =16) array were not at higher risk (OR = 1.06) compared to men with two long repeats [(CAG)n > or =22 and (GGN)n >16)].

CONCLUSIONS

These results suggest that the (CAG)n and (GGN)n repeats in the AR gene do not play a major role in familial prostate cancer.

Authors+Show Affiliations

Department of Urology, University of Washington, Seattle, Washington, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11494335

Citation

Miller, E A., et al. "Polymorphic Repeats in the Androgen Receptor Gene in High-risk Sibships." The Prostate, vol. 48, no. 3, 2001, pp. 200-5.
Miller EA, Stanford JL, Hsu L, et al. Polymorphic repeats in the androgen receptor gene in high-risk sibships. Prostate. 2001;48(3):200-5.
Miller, E. A., Stanford, J. L., Hsu, L., Noonan, E., & Ostrander, E. A. (2001). Polymorphic repeats in the androgen receptor gene in high-risk sibships. The Prostate, 48(3), 200-5.
Miller EA, et al. Polymorphic Repeats in the Androgen Receptor Gene in High-risk Sibships. Prostate. 2001 Aug 1;48(3):200-5. PubMed PMID: 11494335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphic repeats in the androgen receptor gene in high-risk sibships. AU - Miller,E A, AU - Stanford,J L, AU - Hsu,L, AU - Noonan,E, AU - Ostrander,E A, PY - 2001/8/9/pubmed PY - 2001/8/31/medline PY - 2001/8/9/entrez SP - 200 EP - 5 JF - The Prostate JO - Prostate VL - 48 IS - 3 N2 - BACKGROUND: Genetic susceptibility may explain some familial clusters of prostate cancer. The polymorphic androgen receptor (AR) gene, which mediates androgen activity in the prostate, is a candidate gene that may influence predisposition to the disease. METHODS: We analyzed the polymorphic (CAG)n and (GGN)n repeats within the AR gene in men from 51 high-risk prostate cancer sibships, which included at least one affected and one unaffected man (n = 210). We compared repeat lengths of men with prostate cancer (n = 140) to their brothers (n = 70) without disease, stratified by median age at diagnosis of affected men within each sibship. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals to evaluate associations between prostate cancer and repeat length. RESULTS: The OR for prostate cancer associated with short (CAG)n repeats (< 22) compared to longer repeats (> or =22) was 1.13 (95% CI 0.5-2.4) overall, but was higher in sibships with a median age of <66 years at diagnosis (OR = 1.72, 95% CI 0.5-6.0). The (GGN)n array also was not associated with prostate cancer in general. However, in older men (> or = 66 years), there was a modest elevation in risk (OR = 1.56, 95% CI 0.6-4.1) among those with short repeats (GGN of < or =16). Men with both a short (CAG)n (< 22) and a short (GGN)n (< or =16) array were not at higher risk (OR = 1.06) compared to men with two long repeats [(CAG)n > or =22 and (GGN)n >16)]. CONCLUSIONS: These results suggest that the (CAG)n and (GGN)n repeats in the AR gene do not play a major role in familial prostate cancer. SN - 0270-4137 UR - https://www.unboundmedicine.com/medline/citation/11494335/Polymorphic_repeats_in_the_androgen_receptor_gene_in_high_risk_sibships_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0270-4137&amp;date=2001&amp;volume=48&amp;issue=3&amp;spage=200 DB - PRIME DP - Unbound Medicine ER -