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[Relationship between endothelial dysfunction and nitric oxide production in young male smokers].
J Cardiol 2001; 38(1):21-8JC

Abstract

OBJECTIVES

Endothelial function in the brachial arteries is impaired in smokers. However, little is known about this condition in young adult men. The relationship between nitric oxide(NO) production and the endothelial function was investigated in young smokers and compared with non-smokers.

METHODS

Flow-mediated vasodilation of the brachial artery during reactive hyperemia was examined in 10 young smokers(mean age 31 years) and 12 control subjects(mean age 28 years). The vasodilator response in the brachial artery was measured by ultrasonography, and blood samples were obtained from the right cephalic vein. Blood samples were taken at baseline, 30 sec after cuff deflation, and before and 5 min after 0.3 mg of nitroglycerin administration. Blood flow was calculated by multiplying mean flow velocity and vessel cross-sectional area. Plasma NOx(nitrate + nitrite) levels were measured, and the percentage change of NOx production(delta NOx) was calculated as follows: delta NOx(%) = [(NOx concentration at peak flow-mediated vasodilation or after 0.3 mg nitroglycerin administration) - baseline NOx concentration)] x 100/baseline NOx concentration.

RESULTS

Percentage changes in diameter of the brachial artery, NOx production and delta NOx in response to nitroglycerin were not statistically different between the two groups(smokers: 27.6 +/- 8.0 mumol/l, control subjects: 34.0 +/- 8.7 mumol/l). However, percentage change of flow-mediated vasodilation during reactive hyperemia in the young smokers was significantly smaller than that in the control subjects(4.8 +/- 2.7%, 9.1 +/- 5.3%, respectively, p < 0.05). Moreover, delta NOx during reactive hyperemia in the smokers was significantly smaller than that in the control subjects(388.8 +/- 90.2%, 738.0 +/- 284.5%, respectively, p < 0.05).

CONCLUSIONS

The impaired response to reactive hyperemia in young smokers might be associated with decreases in flow-dependent NO production.

Authors+Show Affiliations

First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi-dori 1-754, Niigata, Niigata 951-8510.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

11496432

Citation

Hori, T, et al. "[Relationship Between Endothelial Dysfunction and Nitric Oxide Production in Young Male Smokers]." Journal of Cardiology, vol. 38, no. 1, 2001, pp. 21-8.
Hori T, Matsubara T, Ishibashi T, et al. [Relationship between endothelial dysfunction and nitric oxide production in young male smokers]. J Cardiol. 2001;38(1):21-8.
Hori, T., Matsubara, T., Ishibashi, T., Higuchi, K., Ochiai, S., Takemoto, M., ... Aizawa, Y. (2001). [Relationship between endothelial dysfunction and nitric oxide production in young male smokers]. Journal of Cardiology, 38(1), pp. 21-8.
Hori T, et al. [Relationship Between Endothelial Dysfunction and Nitric Oxide Production in Young Male Smokers]. J Cardiol. 2001;38(1):21-8. PubMed PMID: 11496432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between endothelial dysfunction and nitric oxide production in young male smokers]. AU - Hori,T, AU - Matsubara,T, AU - Ishibashi,T, AU - Higuchi,K, AU - Ochiai,S, AU - Takemoto,M, AU - Imai,S, AU - Nakagawa,I, AU - Ozaki,K, AU - Hatada,K, AU - Mezaki,T, AU - Tsuchida,K, AU - Nasuno,A, AU - Nishio,M, AU - Aizawa,Y, PY - 2001/8/11/pubmed PY - 2001/9/14/medline PY - 2001/8/11/entrez SP - 21 EP - 8 JF - Journal of cardiology JO - J Cardiol VL - 38 IS - 1 N2 - OBJECTIVES: Endothelial function in the brachial arteries is impaired in smokers. However, little is known about this condition in young adult men. The relationship between nitric oxide(NO) production and the endothelial function was investigated in young smokers and compared with non-smokers. METHODS: Flow-mediated vasodilation of the brachial artery during reactive hyperemia was examined in 10 young smokers(mean age 31 years) and 12 control subjects(mean age 28 years). The vasodilator response in the brachial artery was measured by ultrasonography, and blood samples were obtained from the right cephalic vein. Blood samples were taken at baseline, 30 sec after cuff deflation, and before and 5 min after 0.3 mg of nitroglycerin administration. Blood flow was calculated by multiplying mean flow velocity and vessel cross-sectional area. Plasma NOx(nitrate + nitrite) levels were measured, and the percentage change of NOx production(delta NOx) was calculated as follows: delta NOx(%) = [(NOx concentration at peak flow-mediated vasodilation or after 0.3 mg nitroglycerin administration) - baseline NOx concentration)] x 100/baseline NOx concentration. RESULTS: Percentage changes in diameter of the brachial artery, NOx production and delta NOx in response to nitroglycerin were not statistically different between the two groups(smokers: 27.6 +/- 8.0 mumol/l, control subjects: 34.0 +/- 8.7 mumol/l). However, percentage change of flow-mediated vasodilation during reactive hyperemia in the young smokers was significantly smaller than that in the control subjects(4.8 +/- 2.7%, 9.1 +/- 5.3%, respectively, p < 0.05). Moreover, delta NOx during reactive hyperemia in the smokers was significantly smaller than that in the control subjects(388.8 +/- 90.2%, 738.0 +/- 284.5%, respectively, p < 0.05). CONCLUSIONS: The impaired response to reactive hyperemia in young smokers might be associated with decreases in flow-dependent NO production. SN - 0914-5087 UR - https://www.unboundmedicine.com/medline/citation/11496432/[Relationship_between_endothelial_dysfunction_and_nitric_oxide_production_in_young_male_smokers]_ DB - PRIME DP - Unbound Medicine ER -