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Topical and transdermal delivery of antisense oligonucleotides.
Curr Opin Mol Ther. 2001 Jun; 3(3):244-8.CO

Abstract

Antisense oligonucleotides have great potential as therapeutic agents. As a result, a variety of chemistries have been developed to improve the efficacy of these molecules without compromising their specificity. Because the skin is such a large organ with extensive accessibility, it is a natural target for drug delivery. It is, however, an effective barrier, so physical and chemical methods to improve drug penetration have been developed. These enhancement techniques can be combined with modified oligonucleotide chemistries to provide sufficient levels of antisense activity either within the skin or systemically. This review will describe in vitro and in vivo experiments that demonstrate the potential of antisense oligonucleotides to treat both dermal and systemic disorders.

Authors+Show Affiliations

Department of Biological Systems Engineering, University of Nebraska-Lincoln, 68583-0726, USA. rbrand1@unl.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11497348

Citation

Brand, R M.. "Topical and Transdermal Delivery of Antisense Oligonucleotides." Current Opinion in Molecular Therapeutics, vol. 3, no. 3, 2001, pp. 244-8.
Brand RM. Topical and transdermal delivery of antisense oligonucleotides. Curr Opin Mol Ther. 2001;3(3):244-8.
Brand, R. M. (2001). Topical and transdermal delivery of antisense oligonucleotides. Current Opinion in Molecular Therapeutics, 3(3), 244-8.
Brand RM. Topical and Transdermal Delivery of Antisense Oligonucleotides. Curr Opin Mol Ther. 2001;3(3):244-8. PubMed PMID: 11497348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topical and transdermal delivery of antisense oligonucleotides. A1 - Brand,R M, PY - 2001/8/11/pubmed PY - 2002/2/7/medline PY - 2001/8/11/entrez SP - 244 EP - 8 JF - Current opinion in molecular therapeutics JO - Curr Opin Mol Ther VL - 3 IS - 3 N2 - Antisense oligonucleotides have great potential as therapeutic agents. As a result, a variety of chemistries have been developed to improve the efficacy of these molecules without compromising their specificity. Because the skin is such a large organ with extensive accessibility, it is a natural target for drug delivery. It is, however, an effective barrier, so physical and chemical methods to improve drug penetration have been developed. These enhancement techniques can be combined with modified oligonucleotide chemistries to provide sufficient levels of antisense activity either within the skin or systemically. This review will describe in vitro and in vivo experiments that demonstrate the potential of antisense oligonucleotides to treat both dermal and systemic disorders. SN - 1464-8431 UR - https://www.unboundmedicine.com/medline/citation/11497348/Topical_and_transdermal_delivery_of_antisense_oligonucleotides_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:11497348 DB - PRIME DP - Unbound Medicine ER -